Results 141 to 150 of about 171,847 (305)

Things We Do for No Reason™: Prescribing gabapentinoids for pain

Journal of Hospital Medicine, EarlyView.
Abstract Gabapentin and pregabalin are among the most frequently prescribed medications in the United States, with gabapentin in the top 10 and pregabalin in the top 100. Despite FDA approval for only select neuropathic conditions, most use is for off‐label pain indications.
Niti G. Patel, David Goese, Steven M. Belknap, Charles L. Madeira, Jeffrey H. Barsuk   +4 more
wiley   +1 more source

Neuropathic pain evaluation tools

Revista Dor
BACKGROUND AND OBJECTIVES: Pain is a subjective symptom which may be measured by means of its several features, such as intensity, quality, location, duration and impact on daily activities.
Fabiola Dach Eckeli, Rosimary Amorim Teixeira, Áquila Lopes Gouvêa   +2 more
doaj   +1 more source

Value of 2‐Dimensional Shear‐Wave Elastography in Assessing Tibial Nerve Stiffness in Diabetic Peripheral Neuropathy

Journal of Ultrasound in Medicine, EarlyView.
Objectives The morphological alterations of the tibial nerve in patients with diabetes mellitus, both with and without diabetic peripheral neuropathy (DPN), are challenging to differentiate using B‐mode ultrasound. In this study, we assessed the stiffness changes of the tibial nerve by 2‐dimensional shear‐wave elastography (2D‐SWE). Methods We gathered
Jiafan Li, Shaozhi Cai, Yuxia Zhai, Ruoting Zheng, Junbin Du   +4 more
wiley   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Increased mGluR5 in somatostatin-positive interneurons mediates deactivation of the mPFC in a mouse model of neuropathic pain

Experimental and Molecular Medicine
Understanding the neurobiological alterations associated with neuropathic pain is crucial for treatment interventions, but the underlying mechanisms remain unclear.
Mirae Jang, Jaegeon Lee, Seung Ha Kim, Sang Ho Yoon, Myoung-Hwan Kim, Yong-Seok Lee, Sun Kwang Kim, Geehoon Chung, Sang Jeong Kim   +8 more
doaj   +1 more source

Ultrasound‐Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu, Li‐Juan Liu, Fa‐Ming Xu, Xiang‐Yu Fang   +3 more
wiley   +1 more source

Endoscopic Transnasal Apicoectomy for Odontogenic Maxillary Sinusitis

The Laryngoscope, EarlyView.
Endoscopic transnasal apicoectomy (ETA) is a novel multidisciplinary technique that combines endoscopic sinus surgery with apicoectomy via a transnasal approach. ETA enables direct access to periapical lesions while preserving the causative tooth. Our initial experience suggests that this minimally invasive approach is safe, feasible, and effective for
Kenta Fukui, Hiromitsu Hatakeyama, Riku Ando, Akito Ichikawa, Yamato Oki, Yu Matsumoto, Hikaru Takasu, Nobuhiko Oridate   +7 more
wiley   +1 more source

Evaluation of behavior in transgenic mouse models to understand human congenital pain conditions [PDF]

, 2018
BACKGROUND: Containing a brain for signal processing and decision making, and a peripheral component for sensation and response, the nervous system provides higher organisms a powerful method of interacting with their environment.
Bullock, Daniel
core  

Laryngeal Dysfunction Following COVID‐19: A TriNetX Retrospective Cohort Study

The Laryngoscope, EarlyView.
COVID‐19 is associated with an increased incidence of new‐onset laryngeal dysfunction, including chronic cough, dysphagia, voice disorders, vocal fold paralysis, and laryngeal spasm, compared with uninfected controls. Risk peaks one to two years after infection for most outcomes and is influenced by factors such as hospitalization, mechanical ...
Cali Loblundo, Warren B. Chun, Shaun A. Nguyen, Kirsten Meenan, Ashli K. O'Rourke   +4 more
wiley   +1 more source