Results 141 to 150 of about 1,094,883 (299)

Late INa as a Therapeutic Target: New Strategies, Computational Modelling, Drug Development, and Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay, Lynn C. Lunsonga, Peter E. Light, Khaled Barakat   +3 more
wiley   +1 more source

Pharmacology of Neuropathic Pain

The thesis is about the pharmacology of neuropathic pain. Neuropathic pain is a chronic and complicated type of pain that happens when there is damage or disease affecting the nerves responsible for sensing touch, temperature and pain.
Chang, Chin-Chuan
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Radiation-induced neuropathic pain successfully treated with systemic lidocaine administration

, 2018
A Ram Doo,1 Yu Seob Shin,2 Seonwoo Yoo,1 Jong Kwan Park2 1Department of Anesthesiology and Pain Medicine, 2Department of Urology, Chonbuk National University and Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research ...
Doo AR, Yoo S, Shin YS, Park JK
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Targeted Muscle Reinnervation for Intuitive Prosthetic Control

Muscle &Nerve, EarlyView.
ABSTRACT The convergence of medical and technological advances has led to a substantial expansion of therapeutic approaches for patients with limb amputations. Targeted muscle reinnervation (TMR) is one of the strategies to improve control of bionic arms and has been applied for more than two decades. Through surgical rewiring of the nerves responsible
Nitay Maile, Laura Ferrante, Dario Farina, Ulla Al Dabbass, Oskar C. Aszmann, Vlad Tereshenko   +5 more
wiley   +1 more source

Topical phenytoin for the treatment of neuropathic pain

, 2017
David J Kopsky,1 Jan M Keppel Hesselink2 1Institute for Neuropathic Pain, Amsterdam, 2Institute for Neuropathic Pain, Bosch en Duin, the Netherlands Abstract: We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin ...
Kopsky DJ, Keppel Hesselink JM
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Emergencies in Amyotrophic Lateral Sclerosis

Muscle &Nerve, EarlyView.
ABSTRACT Emergencies are frequent in people living with amyotrophic lateral sclerosis (pALS), especially as the disease progresses, and can necessitate urgent evaluation and intervention. Progressive weakness in ALS inevitably increases fall risk, making discussion of fall prevention strategies integral to caring for pALS.
S. Pinar Uysal, Katherine A. Dudley, Stacey Sullivan, Kate T. Brizzi, Katherine M. Burke, Sydney Hall, Kiersten Pease, Joshua N. Goldstein, James D. Berry, Doreen T. Ho   +9 more
wiley   +1 more source

Beyond Joint Hypermobility: Investigating Bladder Dysfunction in Hypermobile Ehlers‐Danlos Syndrome

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction and Objectives Hypermobile Ehlers‐Danlos Syndrome (hEDS) is the most common subtype of Ehlers‐Danlos Syndrome, a group of connective tissue disorders caused by collagen abnormalities. While musculoskeletal features of hEDS are well characterized, its impact on visceral organs, including the bladder, remains underexplored.
Marium Ansari, Mallory Pine, Viktoriya Sapkalova, Emily Chan Brodowsky, Charles R. Powell, Ramzy T. Burns   +5 more
wiley   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Feasibility and Exploratory Outcomes of Foot‐Ankle and Walking Exercises for Diabetic Neuropathy, Stress, and Quality of Life: A Pilot Randomized Controlled Trial

Research in Nursing &Health, EarlyView.
ABSTRACT Foot–ankle and walking exercises have been proposed as potential strategies for managing symptoms in people with diabetic peripheral neuropathy (DPN), yet evidence from primary care remains limited. This pilot study assessed the feasibility and acceptability of these interventions and explored preliminary outcome patterns in DPN, stress, and ...
Siti Fadlilah, Wahyu Rochdiat Murdhiono, Ariyanto Nugroho, Yohanes Andy Rias, Shih Hsin Hsiao, Kai Ling Lee, Po Hao Feng, Hsiu Ting Tsai   +7 more
wiley   +1 more source

Pharmacological treatment of neuropathic pain in older persons

, 2008
Clair Haslam1, Turo Nurmikko21The Walton Centre for Neurology and Neurosurgery, Liverpool, England, UK; 2The Pain Research Institute, Division of Neurological Science, University of Liverpool, Liverpool, England, UKAbstract: Interest and research into ...
Turo Nurmikko, Clair Haslam
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