Results 121 to 130 of about 1,094,883 (299)

Protective Effects of Imeglimin Against Oxaliplatin‐Induced Peripheral Neurotoxicity: Evidence From In Vitro and In Vivo Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Oxaliplatin is a platinum‐based anticancer agent widely used for gastrointestinal malignancies; however, it is known to cause dose‐dependent peripheral neuropathy (OIPN), a characteristic adverse effect. OIPN results in a reduced quality of life and often necessitates dose reduction or discontinuation of oxaliplatin; however, effective ...
Yusuke Koura, Kano Kinjo, Keisuke Mine, Yusuke Mori, Mami Ueda, Risa Kaneko, Yuna Kamiya, Taiga Sonoda, Haruka Mimata, Shunsuke Fujita, Takehiro Kawashiri, Daisuke Kobayashi   +11 more
wiley   +1 more source

Neuropathic pain evaluation tools

Revista Dor
BACKGROUND AND OBJECTIVES: Pain is a subjective symptom which may be measured by means of its several features, such as intensity, quality, location, duration and impact on daily activities.
Fabiola Dach Eckeli, Rosimary Amorim Teixeira, Áquila Lopes Gouvêa   +2 more
doaj   +1 more source

Transperineal Ultrasound in Chronic Pelvic Pain: A Systematic Review

Journal of Clinical Ultrasound, EarlyView.
Graphical abstract illustrating the systematic review process and highlighting key pelvic floor musculature (PFM) alterations detected by transperineal ultrasound (TPU) in patients with chronic pelvic pain (CPP) and associated conditions. These findings provide insights to enhance understanding and management of CPP.
Giulia Paoni Saccone, Noemi Tonti, Valeria Gangale, Maria Grazia Porpora, Federica Tomao, Violante Di Donato, Innocenza Palaia, Giusi Santangelo, Ludovico Muzii, Giuseppe Rizzo, Giorgia Perniola   +10 more
wiley   +1 more source

Inhibition of Neuropathic Pain by a Potent Disintegrin - Triflavin

, 2009
Injury to peripheral nerves may result in severe and intractable neuropathic pain. Many efforts have been focused on the elucidation of the mechanisms of neuropathic pain.
符文美;孫維仁;彭惠琴;劉鴻祺;黃德富, FU, WEN-MEI;SUN, WEI-ZEN;PENG, HUI-CHIN;LIOU, HONG-CHI;HUANG, TUR-FU   +1 more
core  

Gymnema sylvestre: Bioactive constituents, health benefits, and emerging applications in nutraceuticals and functional foods

JSFA reports, EarlyView.
Abstract Gymnema sylvestre (Retz.) R.Br. ex‐Schult., commonly known as “gurmar” or “sugar destroyer,” belongs to the Apocynaceae family and is traditionally used in Ayurveda for diabetes management. This review synthesizes ethnomedicinal evidence with contemporary pharmacological studies, to evaluate the therapeutic properties and mechanistic actions ...
Faiza Saeed, Muhammad Tauseef Sultan, Hassan Raza, Ahmad Mujtaba Noman, Nimra Haroon, Entessar Mohammad Al Jbawi   +5 more
wiley   +1 more source

DNMT3a methylation in neuropathic pain

, 2017
Cuijie Shao, Yong Gao, Dan Jin, Xin Xu, Shuying Tan, Hui Yu, Qingxiang Zhao, Li Zhao, Wansheng Wang, Deqiang Wang Department of Pain, Binzhou Medical University Hospital, Binzhou, China Background: Mu opioid ...
Shao CJ, Zhao L, Tan SY, Jin D, Gao Y, Wang WS, Zhao QX, Wang DQ, Xu X, Yu H   +9 more
core  

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source

Efficacy of Ultrasound‐Guided Intercostal Nerve Block With Liposomal Bupivacaine for Treating Postherpetic Neuralgia in Adult Patients

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The study aimed to investigate the efficacy of ultrasound‐guided intercostal nerve block (ICNB) with liposomal bupivacaine (LB) comparing ropivacaine‐dexamethasone (RD) for treating postherpetic neuralgia (PHN) in adult patients. A total of 108 patients were randomized 1:1 to receive ICNB with LB or ICNB with RD.
Jin Li, Xiang‐Yu Fang
wiley   +1 more source

Intraoperative variability between the anteroposterior and posterior condylar axes in primary TKA supports a 20° proximal trochlear entrance design for unrestricted kinematic alignment

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Unrestricted kinematic alignment (uKA) in total knee arthroplasty (TKA) creates a challenge for trochlear design. Femoral implants designed for mechanical alignment (MA) use asymmetrical posterior bone cuts to adjust axial rotation and optimize patellofemoral tracking. In uKA, posterior bone cuts are calipered resections.
Edward J. McPherson, Jennifer R. Kallini, Diego Dela Pena, Matthew V. Dipane, Madhav Chowdhry   +4 more
wiley   +1 more source

Non‐anatomical MPFL reconstruction and failure to address relevant pathologies are common reasons for treatment injuries following treatment for patellofemoral instability

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Management of patellofemoral instability (PFI) tailored to the individual patoanatomy can be complex with potential pitfalls. However, reports on complications and suboptimal outcomes remain limited. The aim of this study was to analyse problems related to PFI treatment in Denmark.
Louise Marie Helmbæk, Kim Lyngby Mikkelsen, Michael Rindom Krogsgaard   +2 more
wiley   +1 more source