Results 161 to 170 of about 1,846,055 (403)

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Understanding the cellular and molecular pathways of neuropathic pain is fundamental to discovering classes of non-opioid analgesics. Emerging evidence implicates altered sphingolipid metabolism and elevated levels of sphingosine-1-phosphate
Zhoumou Chen, T. Doyle, L. Luongo, T. Largent-Milnes, L. Giancotti, G. Kolar, Silvia Squillace, S. Boccella, John K. Walker, Alexander Pendleton, S. Spiegel, W. Neumann, T. Vanderah, D. Salvemini   +13 more
semanticscholar   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Conditional gene deletion reveals functional redundancy of GABAB receptors in peripheral nociceptors in vivo [PDF]

, 2009
Background Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter which mainly mediates its effects on neurons via ionotropic (GABAA) and metabotropic (GABAB) receptors.
Bernhard Bettler, Dirig DM, Hao JX, Hosny A, Imgard Tegeder, Martina Kurejova, Nitin Agarwal, Rohini Kuner, Stefan Brugger, Vijayan Gangadharan   +9 more
core   +3 more sources

Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain

Pain, 2018
Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain.
E. Navratilova, G. Ji, C. Phelps, Chaoling Qu, Matthew Hein, V. Yakhnitsa, V. Neugebauer, F. Porreca   +7 more
semanticscholar   +1 more source

Late Pregnancy Antiseizure Medication Exposure and Offspring Neurodevelopmental Risk: A Multi‐Child Cohort Study

Annals of Neurology, EarlyView.
Objective Antiseizure medication (ASM) use during pregnancy has increased over the past decade. However, evidence linking prenatal ASM exposure to neurodevelopmental disorders (NDDs) in offspring remains inconsistent. This study evaluated whether prenatal ASM exposure increases the risk of NDDs in children.
Odile Sheehy, Vanina Tchuente, Sherif Eltonsy, Steven Hawken, Padma Kaul, Mark Walker, Michael Pugliese, Roxana Dragan, Anamaria Savu, Lisiane Leal, Lucie Morin, Isabelle Malhamé, Raluca Pana, Anick Bérard   +13 more
wiley   +1 more source

Spinal cord stimulation for predominant low back pain in failed back surgery syndrome: study protocol for an international multicenter randomized controlled trial (PROMISE study) [PDF]

, 2013
Background: Although results of case series support the use of spinal cord stimulation in failed back surgery syndrome patients with predominant low back pain, no confirmatory randomized controlled trial has been undertaken in this patient group to date.
Annemans, Lieven, Desai, Mehul J, Greening, Christine, Kumar, Krishna, North, Richard B, Rigoard, Philippe, Shipley, Jane, Tan, Ye, Taylor, Rod S, Van den Abeele, Carine   +9 more
core   +5 more sources

Botulinum toxin type A for neuropathic pain in patients with spinal cord injury [PDF]

, 2016
Zee‐A Han, Dae Heon Song, Hyun Mi Oh, Myung Eun Chung   +3 more
openalex   +1 more source

Immunological Profiling suggests an Association between Treg dysfunction and Pain in Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Background Pain is the hallmark symptom of osteoarthritis (OA) and its biological drivers remain poorly understood. While the role of innate immunity in OA has been extensively studied, the involvement of adaptive immunity, in particular regulatory T cells (Tregs), is not well understood. Methods We performed omics profiling of peripheral blood from 46
Marie Binvignat, Johanna Dubois, Maria Marco Salvador, Paul Stys, Fabien Pitoiset, Alexandra Roux, Michèle Sastre, Signe Hassler, Roberta Lorenzon, Claire Ribet, Vanessa Mhanna, Hélène Vantomme, Leslie Adda, Pierre Barennes, Nicolas Coatnoan, Kenz Le Gouge, Caroline Aheng, Alice Courties, Lise Minssen, Atul J. Butte, Adrien Six, Michelle Rosenzwajg, Nicolas Tchitchek, Francis Berenbaum, David Klatzmann, Encarnita Mariotti‐Ferrandiz, Jérémie Sellam   +26 more
wiley   +1 more source

Macrophage angiotensin II type 2 receptor triggers neuropathic pain

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Neuropathic pain is a widespread problem that is undermanaged by currently available analgesic drugs. An antagonist of the type II angiotensin II receptor (AT2R) reduces pain behaviors related to neuropathy, suggesting that angiotensin ...
A. Shepherd, A. Mickle, J. Golden, M. Mack, C. Halabi, A. D. de Kloet, V. Samineni, Brian S. Kim, E. Krause, R. Gereau, D. Mohapatra   +10 more
semanticscholar   +1 more source

Pregabalin dependence, withdrawal, suicidality and psychosis reports: A disproportionality analysis of the Australian adverse events database

British Journal of Clinical Pharmacology, EarlyView.
Aims Globally, Australia has the highest per capita consumption rate of pregabalin, commonly prescribed for neuropathic pain. Emerging evidence suggests pregabalin may be associated with the onset or recurrence of several potentially life‐threatening psychiatric events in some individuals.
Amy G. McNeilage, Ali Gholamrezaei, Bridin Murnion, Suzanne Nielsen, Claire E. Ashton‐James   +4 more
wiley   +1 more source