Results 11 to 20 of about 114,925 (309)

Impact of Neuropathic Pain on Health-Related Quality of Life and Disability in Patients with Chronic Low Back Pain [PDF]

Türk Osteoporoz Dergisi, 2018
Objective:Low back pain (LBP) is the most common chronic pain disorder worldwide. Chronic LBP is a mixed pain syndrome associated with nociceptive and neuropathic pain mechanisms.
Bilge Kesikburun, Nihal Tezel, Nuray Gülgönül, Emel Ekşioğlu, Aytül Çakcı   +4 more
doaj   +2 more sources

A genome-wide association study suggests an association of Chr8p21.3 (GFRA2) with diabetic neuropathic pain [PDF]

, 2014
Background: Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients.
Palmer, C. N. A.; id_orcid, H.M. Colhoun, C.N.A. Palmer, Colhoun, H. M., L.A. Donnelly, Liu, Y., Zhou, K., Palmer, C. N A, van Zuydam, N. R., Smith, B. H.; id_orcid, H.A. Deshmukh, N.R. van Zuydam, K. Zhou, A.D. Morris, Donnelly, L. A., Deshmukh, H. A., Morris, A. D., Meng, W., Smith, B. H., Y. Liu, B.H. Smith, W. Meng   +21 more
core   +1 more source

Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]

, 2011
Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Maihöfner Christian, Magerl Walter, Zhu, Jihong, Cascorbi Ingolf, Roman Rolke, Maihöfner, Christian, Binder Andreas, Treede, Rolf-Detlef, Faltraco, Frank, Flor, Herta, Rolf-Detlef Treede, Richter Helmut, Thomas R. Tölle, Nurcan Uçeyler, Huge, Volker, Mike Ufer, Christian Maihöfner, May, Denisa, Andrea Scherens, Uçeyler, Nurcan, Ralf Baron, May Denisa, Huge Volker, Cascorbi, Ingolf, Scherens, Andrea, Ufer, Mike, Gunnar Wasner, Binder, Andreas, Jihong Zhu, Herta Flor, Volker Huge, Helmut Richter, Tölle, Thomas R., Maier Christoph, Maier, Christoph, Thomas R Tölle, Tölle Thomas R., Zhu Jihong, Achim Berthele, Gierthmühlen Janne, Baron Ralf, Faltraco Frank, Magerl, Walter, Andreas Binder, Gierthmühlen, Janne, Christoph Maier, Richter, Helmut, Flor Herta, Wasner Gunnar, Denisa May, Scherens Andrea, Baron, Ralf, Üçeyler Nurcan, Haenisch Sierk, Rolke, Roman, Berthele Achim, Frank Faltraco, Ingolf Cascorbi, Berthele, Achim, Treede Rolf-Detlef, Ufer Mike, Haenisch, Sierk, Wasner, Gunnar, Janne Gierthmühlen, Sierk Haenisch, Rolke Roman, Walter Magerl   +66 more
core   +1 more source

Phenytoin Cream for the Treatment of Neuropathic Pain: Case Series

Pharmaceuticals, 2018
BACKGROUND: Neuropathic pain can be disabling, and is often difficult to treat. Within a year, over half of all patients stop taking their prescribed neuropathic pain medication, which is most probably due to side effects or disappointing analgesic ...
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source

Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. [PDF]

, 2015
Peripheral nerve injury can trigger neuropathic pain in adults but not in infants; indeed, for unknown reasons, neuropathic pain is rare before adolescence. We show here that the absence of neuropathic pain response in infant male rats and mice following
Ji, RR, McKelvey, Rebecca, Ji, Ru Rong, Old, E, Fitzgerald, M, McKelvey, R, Berta, Temugin, Old, Elizabeth, Berta, T, Fitzgerald, Maria   +9 more
core   +1 more source

Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients

Pharmaceuticals, 2018
Background: Phenytoin cream applied topically has been explored in neuropathic pain conditions. In several case series, phenytoin 5% and 10% cream could reduce pain in a clinically relevant way with a fast onset of action within 30 min, and with positive
David J. Kopsky, Jan M. Keppel Hesselink   +1 more
doaj   +1 more source

A genome-wide association study provides evidence of sex-specific involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) with diabetic neuropathic pain [PDF]

, 2015
Neuropathic pain is defined as pain arising as a direct consequence of a lesion or a disease affecting the somatosensory system and it affects around 1 in 4 diabetic patients in the UK.
Harshal A. Deshmukh, Smith, Blair H., Smith, Blair H.; id_orcid, Brown, Matthew, Blair H. Smith, Meng, Weihua, Wellcome Trust Case Control Consortium 2 (WTCCC2), Palmer, Colin N. A., Palmer, Colin N.A., Wellcome Trust Case Control Consortium 2, Louise A. Donnelly, Surrogate Markers For Micro- And Macro-Vascular Hard Endpoints For Innovative Diabetes Tools (SUMMIT) Study Group, Colhoun, Helen M., Helen M. Colhoun, Donnelly, Louise A., Torrance, Nicola, Nicola Torrance, Deshmukh, Harshal A., Weihua Meng, Colin N.A. Palmer, Palmer, Colin N. A.; id_orcid   +20 more
core   +1 more source

Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review

Clinical Case Reports, 2019
Key Clinical Message Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination.
Carmen Montejo, Judith Navarro‐Otano, Gerard Mayà‐Casalprim, Michela Campolo, Jordi Casanova‐Mollá   +4 more
doaj   +1 more source

Neuropathic pain treatment: still a challenge

Neurology International, 2016
Neuropathic pain (NP) is the result of a series of conditions caused by diseases or lesions to the somatosensory system. Due to the better understanding of NP pathophysiology previously unexplored therapies have been used with encouraging results.
Osvaldo J.M. Nascimento, Bruno L. Pessoa, Marco Orsini, Pedro Ribeiro, Eduardo Davidovich, Camila Pupe, Pedro Moreira Filho, Ricardo Menezes Dornas, Lucas Masiero, Juliana Bittencourt, Victor Hugo Bastos   +10 more
doaj   +1 more source

Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

Case Reports in Medicine, 2011
A multimodal stepped care approach has been successfully applied to a patient with complex regional pain syndrome type 1 and severe intractable pain, not responding to regular neuropathic pain medication. The choice to administer drugs in creams was made
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source