Results 21 to 30 of about 1,364,338 (301)

Phenytoin Cream for the Treatment of Neuropathic Pain: Case Series

Pharmaceuticals, 2018
BACKGROUND: Neuropathic pain can be disabling, and is often difficult to treat. Within a year, over half of all patients stop taking their prescribed neuropathic pain medication, which is most probably due to side effects or disappointing analgesic ...
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source

Relationship between Nontraumatic Shoulder Disorders and Neuropathic Pain: Retrospective Observational Analyses of Clinical Features and Background Factors

Anesthesiology Research and Practice, 2023
Background. Accurate identification of neuropathic pain is necessary for appropriate treatment; however, the relationship between nontraumatic shoulder disorders and neuropathic pain remains unknown.
Tsuyoshi Sasaki, Hitoshi Shitara, Tsuyoshi Tajika, Tsuyoshi Ichinose, Noritaka Hamano, Masataka Kamiyama, Atsushi Yamamoto, Tsutomu Kobayashi, Kenji Takagishi, Hirotaka Chikuda   +9 more
doaj   +1 more source

Single-Blind Placebo-Controlled Response Test with Phenytoin 10% Cream in Neuropathic Pain Patients

Pharmaceuticals, 2018
Background: Phenytoin cream applied topically has been explored in neuropathic pain conditions. In several case series, phenytoin 5% and 10% cream could reduce pain in a clinically relevant way with a fast onset of action within 30 min, and with positive
David J. Kopsky, Jan M. Keppel Hesselink   +1 more
doaj   +1 more source

A genome-wide association study provides evidence of sex-specific involvement of Chr1p35.1 (ZSCAN20-TLR12P) and Chr8p23.1 (HMGB1P46) with diabetic neuropathic pain [PDF]

, 2015
Neuropathic pain is defined as pain arising as a direct consequence of a lesion or a disease affecting the somatosensory system and it affects around 1 in 4 diabetic patients in the UK.
Harshal A. Deshmukh, Smith, Blair H., Smith, Blair H.; id_orcid, Brown, Matthew, Blair H. Smith, Meng, Weihua, Wellcome Trust Case Control Consortium 2 (WTCCC2), Palmer, Colin N. A., Palmer, Colin N.A., Wellcome Trust Case Control Consortium 2, Louise A. Donnelly, Surrogate Markers For Micro- And Macro-Vascular Hard Endpoints For Innovative Diabetes Tools (SUMMIT) Study Group, Colhoun, Helen M., Helen M. Colhoun, Donnelly, Louise A., Torrance, Nicola, Nicola Torrance, Deshmukh, Harshal A., Weihua Meng, Colin N.A. Palmer, Palmer, Colin N. A.; id_orcid   +20 more
core   +1 more source

Acute lumbar polyradiculoneuropathy as early sign of methotrexate intrathecal neurotoxicity: Case report and literature review

Clinical Case Reports, 2019
Key Clinical Message Acute paraplegia after treatment with intrathecal methotrexate requires a complete spinal cord neuroimaging as well as electrodiagnostic examination.
Carmen Montejo, Judith Navarro‐Otano, Gerard Mayà‐Casalprim, Michela Campolo, Jordi Casanova‐Mollá   +4 more
doaj   +1 more source

Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. [PDF]

, 2015
Peripheral nerve injury can trigger neuropathic pain in adults but not in infants; indeed, for unknown reasons, neuropathic pain is rare before adolescence. We show here that the absence of neuropathic pain response in infant male rats and mice following
Ji, RR, McKelvey, Rebecca, Ji, Ru Rong, Old, E, Fitzgerald, M, McKelvey, R, Berta, Temugin, Old, Elizabeth, Berta, T, Fitzgerald, Maria   +9 more
core   +1 more source

Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

Case Reports in Medicine, 2011
A multimodal stepped care approach has been successfully applied to a patient with complex regional pain syndrome type 1 and severe intractable pain, not responding to regular neuropathic pain medication. The choice to administer drugs in creams was made
David J. Kopsky, Jan M. Keppel Hesselink
doaj   +1 more source

Neuropathic pain treatment: still a challenge

Neurology International, 2016
Neuropathic pain (NP) is the result of a series of conditions caused by diseases or lesions to the somatosensory system. Due to the better understanding of NP pathophysiology previously unexplored therapies have been used with encouraging results.
Osvaldo J.M. Nascimento, Bruno L. Pessoa, Marco Orsini, Pedro Ribeiro, Eduardo Davidovich, Camila Pupe, Pedro Moreira Filho, Ricardo Menezes Dornas, Lucas Masiero, Juliana Bittencourt, Victor Hugo Bastos   +10 more
doaj   +1 more source

Learning and memory with neuropathic pain : impact of old age and progranulin deficiency [PDF]

, 2013
Persistent neuropathic pain is a frequent consequence of peripheral nerve injuries, particularly in the elderly. Using the IntelliCage we studied if sciatic nerve injury obstructed learning and memory in young and aged mice, each in wild type and ...
Irmgard eTegeder, Vannoni, Elisabetta, Annett eHäussler, Irmgard Tegeder, Wolfer, David P., Elisabetta Vannoni, David P. Wolfer, Tegeder, Irmgard, Wolfer, David P, Elisabetta eVannoni, Annett Häussler, Häussler, Annett, Boris eAlbuquerque, Boris Albuquerque, Albuquerque, Boris, David P Wolfer, Wolfer, David Paul; id_orcid   +16 more
core   +1 more source

Neuropathic pain and psychological morbidity in patients with treated leprosy: a cross-sectional prevalence study in Mumbai. [PDF]

PLoS Neglected Tropical Diseases, 2011
BACKGROUND: Neuropathic pain has been little studied in leprosy. We assessed the prevalence and clinical characteristics of neuropathic pain and the validity of the Douleur Neuropathique 4 questionnaire as a screening tool for neuropathic pain in ...
Estrella Lasry-Levy, Aki Hietaharju, Vivek Pai, Ramaswamy Ganapati, Andrew S C Rice, Maija Haanpää, Diana N J Lockwood   +6 more
doaj   +1 more source