Results 41 to 50 of about 114,925 (309)

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Differential diagnosis of neuropathic pain

Неврология, нейропсихиатрия, психосоматика, 2015
Neuropathic pain is an acute or chronic pain caused by damage to or dysfunction of the peripheral and/or central nervous system. Neuropathic pain is a direct sequel of damage to or disease of the somatosensory nervous system.
Yu. N. Bykov, A. N. Kalyagin
doaj   +1 more source

Effects of interdisciplinary pain rehabilitation programs on neuropathic and non-neuropathic chronic pain conditions – a registry-based cohort study from Swedish Quality Registry for Pain Rehabilitation (SQRP)

BMC Musculoskeletal Disorders, 2023
Background and aim Neuropathic pain arises as a direct consequence of a lesion or disease affecting the somatosensory system. Pharmacological treatments for neuropathic pain often fail despite following guidelines.
Nazdar Ghafouri, Emmanuel Bäckryd, Elena Dragioti, Marcelo Rivano Fischer, Åsa Ringqvist, Björn Gerdle   +5 more
doaj   +1 more source

Pressure ulcer related pain in community populations: a prevalence survey. [PDF]

, 2014
BACKGROUND: Pressure ulcers are costly to the healthcare provider and can have a major impact on patient's quality of life. One of the most distressing symptoms reported is pain.
McGinnis, Elizabeth, Coleman, S, McGinnis, E, Wilson, L, Briggs, Michelle, Michelle Collinson, Nelson, EA, Susanne Coleman, Briggs, M; id_orcid, Collinson, Michelle, Stevenson, Rebecca, Dealey, C, Stubbs, N, E Andrea Nelson, Jane Nixon, Dealey, Carol, Michelle Briggs, Briggs, M, Nixon, J, Stevenson, R, Lyn Wilson, Nikki Stubbs, Brown, Julia, Nelson, E Andrea; id_orcid, Collinson, M, Coleman, Susanne, Elizabeth McGinnis, Nixon, Jane, Rebecca Stevenson, Wilson, Lyn, Julia Brown, Stubbs, Nikki, Carol Dealey, Brown, J   +33 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

NLRP3 inflammasome: a key driver of neuroinflammation and a novel therapeutic target for neuropathic pain [PDF]

Anesthesia and Pain Medicine
Neuropathic pain represents a serious complication arising from a spectrum of disorders that precipitate lesions within the central and peripheral nervous systems. This disabling pain can persist for years, severely diminishing the quality of life of the
Zana Montazeri-Khosh, Ahmad Ebrahimpour, Mahyar Hossein-Zargari, Parsa Taghizadeh-Tabrizi, Mohammad Safari-Sahlabadi, Mohammad Hosein Sheybani-Arani, Nahid Davoodian   +6 more
doaj   +1 more source

Aquaporins and Neuropathic Pain

Frontiers in Bioscience-Landmark, 2023
Neuropathic pain is a chronic secondary pain condition resulting from lesions or diseases of the peripheral or central nervous system (CNS). Neuropathic pain is closely related to edema, inflammation, increased neuronal excitability, and central sensitization caused by glutamate accumulation.
Fei-xiang Wang, Wen-mei Xu, Chi-liang Xu, Jiang Li, Jing-yan Lin   +4 more
openaire   +3 more sources

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Electroacupuncture alleviates inflammatory pain via the activation of GABAergic inhibitory interneurons in mouse spinal dorsal horn

Brain Research Bulletin
Electroacupuncture (EA), a modern adaptation of traditional acupuncture, has shown promising analgesic effects across various pain models. However, the underlying central mechanisms remain insufficiently characterized.
Jiawei Zhang, Yang Bao, Mengye Zhu, Quan Wan, Jinjin Zhang, Xuezhong Cao, Huan Zou, Qinghua Yin, Ziming Chen, Gang Xu, Xuexue Zhang, Daying Zhang, Tao Liu, Yong Zhang   +13 more
doaj   +1 more source

Translational investigation and treatment of neuropathic pain

Molecular Pain, 2012
Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play ...
Xu Bo, Descalzi Giannina, Ye Hai-Rong, Zhuo Min, Wang Ying-Wei   +4 more
doaj   +1 more source