Results 41 to 50 of about 1,094,883 (299)

Chronic preoperative pain and psychological robustness predict acute postoperative pain outcomes after surgery for breast cancer [PDF]

, 2012
Background: Few epidemiological studies have prospectively investigated preoperative and surgical risk factors for acute postoperative pain after surgery for breast cancer.
Thompson, Alastair M., R Powell, Bruce, J., Thornton, A. J. (Alison J.), Powell, R.; id_orcid, Powell, R., Scott, Neil William, Powell, Rachael, Heys, S.D., Thornton, A. J., M Johnston, Wells, M., A M Thompson, Scott, N W, Thompson, A.M., Scott, N. W., M Wells, Johnston, M., Scott, N. W. (Neil W.), Powell, R. (Rachael), J Bruce, Thompson, A. M., Thornton, Alison J, Heys, Steven (Steven D.), Johnston, Marie, Recovery Study Group, Marfizo, S, S D Heys, Marfizo, S., S Marfizo, Wells, M, A J Thornton, Heys, S. D., Bruce, Julie, Wells, Mary, MSc, N W Scott, Bruce, J. (Julie)   +36 more
core   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Translational investigation and treatment of neuropathic pain

Molecular Pain, 2012
Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play ...
Xu Bo, Descalzi Giannina, Ye Hai-Rong, Zhuo Min, Wang Ying-Wei   +4 more
doaj   +1 more source

Factors Associated With Fibromyalgia Diagnosis Among People Meeting Criteria: Results From UK Biobank

Arthritis Care &Research, EarlyView.
Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim, Gary J. Macfarlane, Marcus J. Beasley   +2 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Electroacupuncture alleviates inflammatory pain via the activation of GABAergic inhibitory interneurons in mouse spinal dorsal horn

Brain Research Bulletin
Electroacupuncture (EA), a modern adaptation of traditional acupuncture, has shown promising analgesic effects across various pain models. However, the underlying central mechanisms remain insufficiently characterized.
Jiawei Zhang, Yang Bao, Mengye Zhu, Quan Wan, Jinjin Zhang, Xuezhong Cao, Huan Zou, Qinghua Yin, Ziming Chen, Gang Xu, Xuexue Zhang, Daying Zhang, Tao Liu, Yong Zhang   +13 more
doaj   +1 more source

Cancer-related neuropathic pain at the outpatient pain clinic of the Clinical centre of Serbia: Cancer-related neuropathic pain [PDF]

Serbian Journal of Anesthesia and Intensive Therapy, 2016
Introduction: Neuropathic pain is defined as chronic pain caused by disease or lesion of somatosensory nerve system. Positive and negative signs and symptoms are manifestation of neuropathic pain.
Jovičić Jelena, Mimić Ana, Brkić Tatjana, Garić Aleksandra   +3 more
doaj   +1 more source

Multidimensional pain phenotypes after Traumatic Brain Injury

Frontiers in Pain Research, 2022
More than 50% of individuals develop chronic pain following traumatic brain injury (TBI). Research suggests that a significant portion of post-TBI chronic pain conditions is neuropathic in nature, yet the relationship between neuropathic pain ...
Linda E. Robayo, Linda E. Robayo, Varan Govind, Roberta Vastano, Roberta Vastano, Elizabeth R. Felix, Loriann Fleming, Loriann Fleming, Nicholas P. Cherup, Nicholas P. Cherup, Eva Widerström-Noga, Eva Widerström-Noga, Eva Widerström-Noga   +12 more
doaj   +1 more source

Neuropathic pain component and its association with time elapsed since pain onset in patients with low back pain

, 2023
Background: Time elapsed since pain onset might affect the likelihood of neuropathic component in low back pain. The aim of this study was to investigate the relationship between neuropathic pain component and pain duration in patients with low back pain
김희정, 윤경봉, 김신형, 반민지   +3 more
core   +1 more source