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BMC Musculoskeletal Disorders, 2023 Background and aim Neuropathic pain arises as a direct consequence of a lesion or disease affecting the somatosensory system. Pharmacological treatments for neuropathic pain often fail despite following guidelines.
Nazdar Ghafouri +5 more
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Pharmaceutics, 2021 Neuropathic pain in humans results from an injury or disease of the somatosensory nervous system at the peripheral or central level. Despite the considerable progress in pain management methods made to date, peripheral neuropathic pain significantly ...
Magdalena Kocot-Kępska +6 more
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Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son +3 more
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NLRP3 inflammasome: a key driver of neuroinflammation and a novel therapeutic target for neuropathic pain [PDF]
Anesthesia and Pain MedicineNeuropathic pain represents a serious complication arising from a spectrum of disorders that precipitate lesions within the central and peripheral nervous systems. This disabling pain can persist for years, severely diminishing the quality of life of the
Zana Montazeri-Khosh +6 more
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Arthritis Care &Research, EarlyView.Objective The diagnosis of fibromyalgia (FM) is challenging due to the absence of definitive biomarkers, numerous overlapping comorbidities, and its reliance on patient‐reported symptoms. Discrepancies between diagnostic criteria and clinical practice imply the possibility of diagnostic biases, complicating timely and accurate identification.
Sung‐A Kim +2 more
wiley +1 more source
Spinal cord stimulation for neuropathic pain: current perspectives [PDF]
, 2014 Tilman Wolter Interdisciplinary Pain Centre, University Hospital Freiburg, Freiburg, Germany Abstract: Neuropathic pain constitutes a significant portion of chronic pain.
Wolter, Tilman, Wolter T
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Advanced Healthcare Materials, EarlyView.Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez +12 more
wiley +1 more source
Investigation of the Neuropathic Pain Caused by Syringomyelia Associated with Chiari I Malformation [PDF]
Asian Spine Journal, 2019 Study Design Retrospective cohort study. Purpose To investigate the correlation between the syrinx morphology and neuropathic pain caused by syringomyelia associated with Chiari I malformation.
Toshitaka Seki +5 more
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Advanced Science, EarlyView.In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang +11 more
wiley +1 more source
Brain Research BulletinElectroacupuncture (EA), a modern adaptation of traditional acupuncture, has shown promising analgesic effects across various pain models. However, the underlying central mechanisms remain insufficiently characterized.
Jiawei Zhang +13 more
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