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Translational investigation and treatment of neuropathic pain
Molecular Pain, 2012 Neuropathic pain develops from a lesion or disease affecting the somatosensory system. Translational investigations of neuropathic pain by using different animal models reveal that peripheral sensitization, spinal and cortical plasticity may play ...
Xu Bo +4 more
doaj +1 more source
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
Pharmacologic Aspect of Neuropathic Pain [PDF]
, 2015 Neuropathic pain is pain arising from nerve damage to the conductive pathways of pain (ranging from nociceptors to post central gyrus). Neuropathic pain can be caused by 1) Carcinomas, 2) Trap/compressive, 3) Congenital, 4) Immunomediated, 5) Infection,
Mutiawati, Endang +3 more
core +2 more sources
Computational and Structural Biotechnology JournalMammalian neurophysiology vitally depends on the stable functioning of transmembrane, pore-forming voltage-sensing proteins known as voltage-gated sodium channels (NaVChs).
Markos N. Xenakis, Angelika Lampert
doaj +1 more source
Aquaporins and Neuropathic Pain
Frontiers in Bioscience-Landmark, 2023 Neuropathic pain is a chronic secondary pain condition resulting from lesions or diseases of the peripheral or central nervous system (CNS). Neuropathic pain is closely related to edema, inflammation, increased neuronal excitability, and central sensitization caused by glutamate accumulation.
Fei-xiang Wang +4 more
openaire +3 more sources
Pressure ulcer related pain in community populations: a prevalence survey. [PDF]
, 2014 BACKGROUND: Pressure ulcers are costly to the healthcare provider and can have a major impact on patient's quality of life. One of the most distressing symptoms reported is pain.
McGinnis, Elizabeth +33 more
core +2 more sources
Neuropathic Pain in Females with Fibromyalgia Syndrome: The Role of Obesity
, 2023 Objective:This study aimed to assess the impact of obesity on neuropathic pain, fibromyalgia symptoms, and quality of life in female patients diagnosed with fibromyalgia syndrome.Materials and Methods:This study enrolled 40 normal-weight and 40 obese ...
Meltem Yener Mankır +7 more
core +1 more source
Advanced Science, EarlyView.Elevated GLUT1‐driven glycolysis and disrupted selenoprotein‐dependent redox homeostasis drive osteoarthritic progression. Intra‐articular mannose‐modified selenium nanoparticles (M‐SeNPs) selectively target hypermetabolic synovial cells to reprogram aberrant glycolysis and restore endogenous antioxidant defenses.
Yu‐Qing Zou +15 more
wiley +1 more source
Differential diagnosis of neuropathic pain
Неврология, нейропсихиатрия, психосоматика, 2015 Neuropathic pain is an acute or chronic pain caused by damage to or dysfunction of the peripheral and/or central nervous system. Neuropathic pain is a direct sequel of damage to or disease of the somatosensory nervous system.
Yu. N. Bykov, A. N. Kalyagin
doaj +1 more source
Cancer-related neuropathic pain at the outpatient pain clinic of the Clinical centre of Serbia: Cancer-related neuropathic pain [PDF]
Serbian Journal of Anesthesia and Intensive Therapy, 2016 Introduction: Neuropathic pain is defined as chronic pain caused by disease or lesion of somatosensory nerve system. Positive and negative signs and symptoms are manifestation of neuropathic pain.
Jovičić Jelena +3 more
doaj +1 more source