Results 61 to 70 of about 114,925 (309)

Treatment of Neuropathic Pain [PDF]

Seminars in Neurology, 2010
Neuropathic pain is a common symptom associated with peripheral neuropathy and can be as or more disabling than the effects of nerve damage from the neuropathy. Though treatment of the underlying pathophysiology causing neuropathies may not be possible, treatment of neuropathic pain is.
openaire   +2 more sources

Gabapentin in neuropathic pain syndromes: a randomised, double-blind, placebo-controlled trial

, 2002
A double-blind, randomised, placebo-controlled 8-week study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain, using doses up to 2400 mg/day.
Neuropathic Pain Study Grp, Serpell, M.G., Neuropathic Pain Study Grp,   +2 more
core   +1 more source

Neuropathic Pain in Postmenopausal Osteoporosis Patients Effect on Sleep Quality, Quality of Life and Depression

, 2022
Objective:In this study, our aimed was to investigate the frequency of neuropathic pain in women diagnosed with postmenopausal osteoporosis (OP), its effects on sleep quality, quality of life, depression and the relationship between these findings ...
Gülseren Dost Sürücü, Dilay Eken-Gedik, Semra Teker   +2 more
core   +1 more source

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Silencing of lncRNA PKIA-AS1 Attenuates Spinal Nerve Ligation-Induced Neuropathic Pain Through Epigenetic Downregulation of CDK6 Expression

Frontiers in Cellular Neuroscience, 2019
Neuropathic pain (NP) is among the most intractable comorbidities of spinal cord injury. Dysregulation of non-coding RNAs has also been implicated in the development of neuropathic pain. Here, we identified a novel lncRNA, PKIA-AS1, by using lncRNA array
Jian-Zhong Hu, Jian-Zhong Hu, Zi-Jie Rong, Zi-Jie Rong, Miao Li, Miao Li, Ping Li, Ping Li, Ping Li, Li-Yuan Jiang, Li-Yuan Jiang, Zi-Xiang Luo, Zi-Xiang Luo, Chun-Yue Duan, Chun-Yue Duan, Yong Cao, Yong Cao, Hong-Bin Lu, Hong-Bin Lu   +18 more
doaj   +1 more source

Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons

Cells, 2020
Neuropathic pain exerts a global burden caused by the lesions in the somatosensory nerve system, including the central and peripheral nervous systems. The mechanisms of nerve injury-induced neuropathic pain involve multiple mechanisms, various signaling ...
Ti-Yen Yeh, I-Wei Luo, Yu-Lin Hsieh, To-Jung Tseng, Hao Chiang, Sung-Tsang Hsieh   +5 more
doaj   +1 more source

Management of neuropathic pain [PDF]

Journal of General and Family Medicine, 2017
AbstractNeuropathic pain is intractable pain caused by damage to the nervous system. Recent approval and expansion of the indications of a series of drugs are expected to improve the treatment strategies for neuropathic pain. Here, we present an outline of pain transmission pathways and relevant pharmacological effects, along with points to consider in
Nishikawa, Noriko, Nomoto, Masahiro
openaire   +2 more sources

Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain [PDF]

, 2005
It has been proposed that death of inhibitory interneurons in the dorsal horn contributes to the neuropathic pain that follows partial nerve injury. In this study, we have used two approaches to test whether there is neuronal death in the dorsal horn in ...
Polgar, Erika, Todd, A.J., Arham, A.Z., Hughes, D.I.   +3 more
core   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

Advanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh, Adan Moallemi, Elham Mohseni Vadeghani, Samuel Tretjakov, Brianna Tsuyuki, Alexander Golab, Benjamin Rever, Wolfram Tetzlaff, Dena Shahriari   +8 more
wiley   +1 more source