Results 71 to 80 of about 1,364,338 (301)
Advanced Science, EarlyView.Ilizarov bone transport accelerates healing of soft‐tissue wounds through unclear mechanisms. In a rat model, sustained mechanical distraction elicits calcitonin gene‐related peptide (CGRP)‐dominant sensory reinnervation, creating a niche that shifts immune cells from inflammatory to repair‐promoting states and speeds re‐epithelialization.
Yueliang Zhu +9 more
wiley +1 more source
Protein Kinases as Mediators for miRNA Modulation of Neuropathic Pain
CellsNeuropathic pain is a chronic condition resulting from injury or dysfunction in the somatosensory nervous system, which leads to persistent pain and a significant impairment of quality of life.
Leah Chang, Zala Čok, Lei Yu
doaj +1 more source
Botulinum Toxin for Central Neuropathic Pain
Toxins, 2018 Botulinum toxin (BTX) is widely used to treat muscle spasticity by acting on motor neurons. Recently, studies of the effects of BTX on sensory nerves have been reported and several studies have been conducted to evaluate its effects on peripheral and ...
Jihye Park, Myung Eun Chung
doaj +1 more source
Multidimensional pain phenotypes after Traumatic Brain Injury
Frontiers in Pain Research, 2022 More than 50% of individuals develop chronic pain following traumatic brain injury (TBI). Research suggests that a significant portion of post-TBI chronic pain conditions is neuropathic in nature, yet the relationship between neuropathic pain ...
Linda E. Robayo +12 more
doaj +1 more source
Advanced Science, EarlyView.In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang +10 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Neuropathic pain (NP) is among the most intractable comorbidities of spinal cord injury. Dysregulation of non-coding RNAs has also been implicated in the development of neuropathic pain. Here, we identified a novel lncRNA, PKIA-AS1, by using lncRNA array
Jian-Zhong Hu +18 more
doaj +1 more source
Advanced Intelligent Systems, EarlyView.Wearable sensors usually warn through sight or sound, channels that become unreliable under protective equipment or in noise. Reverse haptic alerting inverts this flow: Stimuli‐responsive materials convert chemical and biological signals into cues felt through the skin, while a machine‐learned digital twin of tactile perception personalizes the body ...
Hwanhee Yoo +5 more
wiley +1 more source
Cells, 2020 Neuropathic pain exerts a global burden caused by the lesions in the somatosensory nerve system, including the central and peripheral nervous systems. The mechanisms of nerve injury-induced neuropathic pain involve multiple mechanisms, various signaling ...
Ti-Yen Yeh +5 more
doaj +1 more source
Treatment of Neuropathic Pain [PDF]
Seminars in Neurology, 2010 Neuropathic pain is a common symptom associated with peripheral neuropathy and can be as or more disabling than the effects of nerve damage from the neuropathy. Though treatment of the underlying pathophysiology causing neuropathies may not be possible, treatment of neuropathic pain is.
openaire +2 more sources
Oxcarbazepine for neuropathic pain [PDF]
Cochrane Database of Systematic Reviews, 2013 Neuropathic pain is difficult to treat. Oxcarbazepine is an anticonvulsant drug closely related to carbamazepine and is reportedly better tolerated. Oxcarbazepine has been reported to be efficacious in the treatment of neuropathic pain.To determine the benefits and harms of oxcarbazepine for different forms of neuropathic pain.We searched the Cochrane ...
Muke, Zhou +5 more
openaire +3 more sources