Results 71 to 80 of about 114,925 (309)

Neuropathic pain: targeting the melatonin MT₂ receptor

South African Family Practice, 2016
Neuropathic pain affects a large proportion of the population and reduces a person’s ability to perform optimally. In South Africa, there are a host of factors that hinder the correct diagnosis and treatment of neuropathic pain.
N. Smith, H. Ismail, N. Schellack
doaj   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Treadmill running on neuropathic pain: via modulation of neuroinflammation

Frontiers in Molecular Neuroscience
Neuropathic pain is a type of chronic pain caused by an injury or somatosensory nervous system disease. Drugs and exercise could effectively relieve neuropathic pain, but no treatment can completely stop neuropathic pain. The integration of exercise into
Wei-Chun He, Shuang-Long Hou, Kai-Bin Wang, Ning Xu, Ke Li, Ting Xiong, Jing Luo, Jing Luo   +7 more
doaj   +1 more source

A Millimeter‐Scale Implantable Magneto–Mechano–Electric Transducer Based on BTO Piezoelectric Ceramics for Remote Wireless Electrical Stimulation of Injured Sciatic Nerves

Advanced Science, EarlyView.
We report a fully wireless, circuit‐free neural stimulator built on a millimetric magneto‐mechano‐electric (MME) cantilever transducer (3 × 10 × 5 mm) with a barium titanate (BTO) piezoelectric ceramic core. Under low‐frequency alternating magnetic fields, the MME cantilever mechanically oscillates, inducing stress on the BTO element and thereby ...
Yijing Wang, Jingyu Tian, Zhe Xu, Cuiling Zhang, Jingen Wu, Ming Liu, Zhilu Ye, Xiaohui Zhang   +7 more
wiley   +1 more source

Cross-sectional comparison of cannabis use in adults with neuropathic versus non-neuropathic pain

Frontiers in Pain Research
IntroductionCannabis has been decriminalized by many states and shows promise in treating both neuropathic and non-neuropathic pain through its interaction with the endocannabinoid system and anti-inflammatory effects.
Carl Joshua P. Laroya, Carl Joshua P. Laroya, Crystal Lederhos Smith, Ross J. Bindler, Michael G. McDonell, Jamie Lewis, Jamie Lewis, Marian Wilson   +7 more
doaj   +1 more source

Lysophosphatidic acid is associated with neuropathic pain intensity in humans: An exploratory study.

PLoS ONE, 2018
The underlying mechanisms of neuropathic pain remain to be elucidated. Basic animal research has suggested that lysophosphatidic acids, which are bioactive lipids produced by autotaxin from lysophosphatidylcholine, may play key roles in the initiation ...
Ken Kuwajima, Masahiko Sumitani, Makoto Kurano, Kuniyuki Kano, Masako Nishikawa, Baasanjav Uranbileg, Rikuhei Tsuchida, Toru Ogata, Junken Aoki, Yutaka Yatomi, Yoshitsugu Yamada   +10 more
doaj   +1 more source

Statins and Neuropathic Pain: A Narrative Review

Pain and Therapy, 2020
The frequently prescribed drug class of statins have pleiotropic effects and have been implicated in neuropathic pain syndromes. This narrative review examines studies of statin-induced neuropathic pain which to date have been conducted only in animal ...
Joseph V. Pergolizzi, Peter Magnusson, Jo Ann LeQuang, Robin Razmi, Gianpietro Zampogna, Robert Taylor   +5 more
doaj   +1 more source

Opioids for neuropathic pain [PDF]

Cochrane Database of Systematic Reviews, 2013
This is an updated version of the original Cochrane review published in Issue 3, 2006, which included 23 trials. The use of opioids for neuropathic pain remains controversial. Studies have been small, have yielded equivocal results, and have not established the long-term profile of benefits and risks for people with neuropathic pain.To reassess the ...
Ewan D, McNicol, Ayelet, Midbari, Elon, Eisenberg   +2 more
openaire   +2 more sources

Pharmacological Treatment in Neuropathic Pain Management

, 2021
Neuropathic pain is a pain condition, usually chronic, in which an abnormal neural activity arises secondary to an injury, disease or some kind of dysfunction of the nervous system. Often neuropathic pain has complex symptoms – for instance, burning pain,
Atladottir, Nadia Lind
core  

Lesion Site‐Targeted Microspheres Modulate Nav1.7‐Related Signaling for Osteoarthritis Treatment

Advanced Science, EarlyView.
Cartilage‐targeted carbamazepine‐loaded WYRGRL‐modified composite microspheres (CBZ/WCOM) anchor to exposed type II collagen in osteoarthritic lesions and release carbamazepine under acidic conditions. This bind‐then‐release platform modulates Nav1.7‐related sodium signaling, Na⁺/Ca²⁺ exchanger‐associated Ca2+ dynamics, and heat shock protein 70 ...
Cheng Chen, Jiaying Li, Jinjin Ma, Xiaonan Yuan, Yao Xiao, Yang Zhang, Yuan Chen, Hao Jiang, Hui He, Jie Hu, Qianglong Chen, Jinniu Zhang, Bin Li, Yun Zhou, Fengxuan Han, Yong Wang   +15 more
wiley   +1 more source