Results 241 to 250 of about 192,256 (352)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang   +18 more
wiley   +1 more source

Outcome Measures in Randomized-controlled Trials of Neuropathic Pain Conditions

open access: green, 2014
Poonam Mehta   +4 more
openalex   +2 more sources

Opioids in breast cancer: Between analgesia and modulation of tumour progression

open access: yesBritish Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun   +2 more
wiley   +1 more source

Artificial Intelligence Chatbots as Virtual Patients in Dental Education: A Constructivist Approach to Classroom Implementation

open access: yesEuropean Journal of Dental Education, EarlyView.
ABSTRACT Introduction Advances in artificial intelligence (AI) have led to new possibilities for AI role‐play in classroom settings, where generative pre‐trained transformers (GPTs) and chatbots can potentially simulate interactions with patients.
Bree Jones   +2 more
wiley   +1 more source

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