Results 51 to 60 of about 1,609 (181)

Genetic Diversity, Latency and Co-Infections [PDF]

, 2016
Alphaherpesviruses are highly prevalent in equine populations and co- infections with more than one of these viruses’ strains frequently diagnosed. Lytic replication and latency with subsequent reactivation, along with new episodes of disease, can be ...
Abdelgawad, Azza, Damiani, Armando, East, Marion L., Greenwood, Alex D., Ho, Simon Y. W., Osterrieder, Nikolaus, Strauss, Guenter, Szentiks, Claudia A.   +7 more
core   +1 more source

Extracellular and Membrane Protein: Structure, Biological Functions, Diseases, and an Emerging Modality for Drug Discovery

MedComm, Volume 7, Issue 4, April 2026.
Targeted protein degradation represents a paradigm shift from traditional protein inhibition to complete protein elimination. This is achieved through three main strategies for degrading extracellular and membrane proteins: recruitment of cell‐surface LTRs, engagement of intracellular proteins, and receptor‐independent mechanisms.
Mengqing Zhao, Wenhao Yin, Jianjian Han, Huimin Wang, Zheng Liu, Lilong Liu, Wuxiang Mao   +6 more
wiley   +1 more source

Identification of a New Equid Herpesvirus 1 DNA Polymerase (ORF30) Genotype with the Isolation of a C₂₂₅₄/H₇₅₂ Strain in French Horses Showing no Major Impact on the Strain Behaviour

Viruses, 2020
Equid herpesvirus 1 is one of the most common viral pathogens in the horse population and is associated with respiratory disease, abortion and still-birth, neonatal death and neurological disease. A single point mutation in the DNA polymerase gene (ORF30:
Gabrielle Sutton, Côme Thieulent, Christine Fortier, Erika S. Hue, Christel Marcillaud-Pitel, Alexis Pléau, Alain Deslis, Edouard Guitton, Romain Paillot, Stéphane Pronost   +9 more
doaj   +1 more source

Dissecting the Determinants of Neuropathogenesis of the Murine Oncornaviruses [PDF]

, 1966
Digitalitzat per ...
Portis, John L., Lynch, William P.
core   +1 more source

Red cell adenylate kinase deficiency in China: molecular study of 2 new mutations (413G > A, 223dupA)

BMC Medical Genomics, 2022
Background Adenylate kinase (AK) is a monomolecular enzyme widely found in a variety of organisms. It mainly catalyses the reversible transfer of adenosine nucleotide phosphate groups and plays an important role in maintaining energy metabolism.
Sijia He, Hongbo Chen, Xia Guo, Ju Gao
doaj   +1 more source

Rational engineering of microRNA-regulated viruses for cancer gene therapy [PDF]

, 2013
MicroRNAs (miRNAs) are small noncoding RNA molecules that have important regulatory roles in a wide range of biological processes. miRNAs are often expressed in a tissue- and/or differentiation state-specific patterns, and it is estimated that miRNAs can
Ylösmäki, Erkko
core  

Abortigenic but not neurotropic equine herpes virus 1 modulates the interferon antiviral defense [PDF]

, 2018
Equine herpesvirus 1 (EHV1) is considered as a major pathogen of Equidae, causing symptoms from mild respiratory disease to late-termabortion and neurological disorders.
Favoreel, Herman, Hussey, Gisela Soboll, Laval, Kathlyn, Maes, Roger K, Nauwynck, Hans, Poelaert, Katrien, Van Cleemput, Jolien   +6 more
core   +4 more sources

Therapeutic Effects of Nizubaglustat in a Mouse Model of GM2 Gangliosidosis

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Nizubaglustat is a novel selective inhibitor of glucosylceramide synthase (GCS) and the non‐lysosomal glucocerebrosidase (NLGase, GbA2) with brain penetrant properties. It is currently in clinical development as an oral treatment for rare lysosomal storage diseases with neurological involvement. One such disease group called GM2 gangliosidosis,
Kyle Landskroner, Kshitiz Singh, Melissa Mitchell, Jagdeep S. Walia   +3 more
wiley   +1 more source

Immunodeficiencies caused by infectious diseases. [PDF]

, 2010
Immunodeficiencies caused by infectious agents may result from disruption of normal host barriers or dysregulation of cellular immunity, the latter serving to promote survival of the infectious agent through immune evasion.
Sykes, Jane
core  

Novel Marmoset (Callithrix jacchus) Model of Human Herpesvirus 6A and 6B Infections: Immunologic, Virologic and Radiologic Characterization [PDF]

, 2013
Human Herpesvirus 6 (HHV-6) is a ubiquitous virus with an estimated seroprevalence of 95% in the adult population. HHV-6 is associated with several neurologic disorders, including multiple sclerosis, an inflammatory demyelinating disease affecting the ...
Ellis, Mary E, Gaitán, María I., Harberts, Erin, Jacobson, Steven, Leibovitch, Emily, Macri, Sheila, Maggi, Pietro, Motanic, Kelsey, Reich, Daniel S., Silva, Afonso, Westmoreland, Susan V., Wohler, Jillian E.   +11 more
core   +2 more sources