Results 151 to 160 of about 174,921 (327)

NEUROPATHOLOGY IN THE BIBLE.

open access: yesSouth African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1996
No Abstract.
openaire   +3 more sources

Digital Therapeutics for Alzheimer's and Parkinson's Diseases: Current Trends and Future Perspectives

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) and Parkinson's disease (PD), which are characterized by the accumulation of misfolded protein aggregates and cognitive/motor dysfunction, are the most prevalent neurodegenerative diseases (NDDs). Despite strategic investigations aimed at augmenting the pharmaceutical pipeline, available drugs for AD and PD merely slow
Yoo Joo Jeong   +12 more
wiley   +1 more source

Accelerated water residual removal in MRS: Exploring deep learning versus fitting‐based approaches

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Removing water residual signals from MRS spectra is crucial for accurate metabolite quantification. However, currently available algorithms are computationally intensive and time‐consuming, limiting their clinical applicability. This work aims to propose and validate two novel pipelines for fast water residual removal in MRS.
Federico Turco   +2 more
wiley   +1 more source

TREM2 Downregulation Disrupts Microglial Function and Synaptic Pruning Through RA/RARα Signaling: Mechanisms Underlying Autism‐Like Behaviors

open access: yesPediatric Discovery, EarlyView.
Downregulation of TREM2 induces autism‐like behaviors in healthy rats by impairing microglial function and triggering aberrant synaptic pruning. RA/RARα signaling pathway modulates alterations in TREM2 expression. Serum sTREM2 levels correspond to alterations in brain TREM2 expression.
Min Lu   +9 more
wiley   +1 more source

Global, regional, and national burden of brain and central nervous system cancer in children and adolescents, 1990–2021: A systematic analysis of the Global Burden of Disease study 2021

open access: yesPediatric Investigation, EarlyView.
From 1990 to 2021, age‐standardized mortality rates and disability‐adjusted life year rates of brain and central nervous system cancer decreased in most regions and countries. The disease burden is generally negatively correlated with the socio‐demographic index level, and health inequalities persist across different countries and regions.
Yafang Deng, Qiang Gao, Wei Zhang
wiley   +1 more source

Neuropathology on Trial [PDF]

open access: yesJournal of Neuropathology & Experimental Neurology, 2020
openaire   +3 more sources

Coupling CZE, Liquid‐Phase Ion Mobility, to MS/MS for Quantitative Top‐Down Proteomics: Revealing Significant Proteoform Differences Between Healthy and Alzheimer's Disease Brains

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline and pathological protein aggregation. Comprehensive quantitative proteomics of brain tissues from AD patients is critical for pursuing a better understanding of the molecular mechanisms that drive AD progression.
Mehrdad Falamarzi Askarani   +3 more
wiley   +1 more source

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