The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders
Brain Pathology, EarlyView.Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu +11 more
wiley +1 more source
A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8
Brain Pathology, EarlyView.We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren +5 more
wiley +1 more source
The silent consequence of overdose: The case for brain injury‐informed opioid treatment
Addiction, EarlyView.
Nathaniel Day +4 more
wiley +1 more source
Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration
Brain Pathology, EarlyView.Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk +6 more
wiley +1 more source
A 67‐year‐old man with a spinal extramedullary mass
Brain Pathology, EarlyView.
Marcella Callea +3 more
wiley +1 more source
Molecular heterogeneity and prognostic biomarkers in primary meningeal melanocytic tumors
Brain Pathology, EarlyView.Integrated molecular profiling reveals biological heterogeneity among primary meningeal melanocytic tumors, identifying intermediate‐grade PMMT subgroups with distinct recurrence risk. Molecular alterations including SF3B1 mutations and chromosome 8q gains support prognostic stratification, while PRKAR1A alterations and chromosome 17/21q losses aid ...
Rosina Paterra +6 more
wiley +1 more source
Insights into the pathological basis of dementia from population-based neuropathology studies [PDF]
Alzheimer\u27s Disease, Dementia Neuropathology, Epidemiological Neuropathology, Lewy Body Disease, Population-Representative Neuropathology, Vascular ...
on behalf of CFAS +7 more
core +1 more source
Brain Pathology, EarlyView.Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar +12 more
wiley +1 more source
Clinical evaluation of the CrossNN DNA methylation classifier for central nervous system tumors
Brain Pathology, EarlyView.CrossNN demonstrated non‐inferiority to the Heidelberg CNS Tumor Methylation Classifier. A dual‐classifier approach increased the number of clinically informative classifications with correct tumor type assignment while maintaining a low rate of incorrect predictions.
Jonas Dahnoun +8 more
wiley +1 more source
Elevated Expression of Caveolin-1 Reflects a Poor Prognosis in Patients With Primary Central Nervous System Lymphomas. [PDF]
NeuropathologySugita Y +6 more
europepmc +1 more source