Results 121 to 130 of about 171,935 (300)

Associations of Monocyte Glucocerebrosidase with Cognition and Cholinergic Innervation in GBA1 Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The GBA1 gene encodes the lysosomal enzyme glucocerebrosidase (GCase). Parkinson's disease (PD) patients carrying a GBA1 variant (GBA‐PD) exhibit faster cognitive decline, linked to cholinergic degeneration. Objectives The aim was to investigate whether GCase activity, measured in monocytes, correlates with cognitive dysfunction or ...
Sofie Slingerland, Sygrid van der Zee, Sven C.D. van Ijzendoorn, Anne C. Slomp, Jeffrey M. Boertien, Sanne K. Meles, Arjan Kol, Marie Geerlings, Teus van Laar   +8 more
wiley   +1 more source

A life course approach to cognitive reserve: A model for cognitive aging and development? [PDF]

, 2005
Anderson, Anstey, Arbuckle, Barker, Bassuk, Becker, Bennett, Cockburn, Deary, Deary, Del Ser, Dik, Elias, Garrett, Glagov, Graves, Guo, Hassan, Hofman, Jefferis, Katzman, Katzman, Kempermann, Kesler, Kramer, Lee, MacLullich, Maguire, Matte, McGurn, McKhann, Meyer, Mortimer, Plomin, Rabbitt, Reynolds, Richards, Richards, Richards, Richards, Roman, Roth, Rutter, Satz, Scarmeas, Scarmeas, Schaie, Schmand, Seckl, Shenkin, Shi, Snowdon, Staff, Starr, Stern, Stern, Stern, Stern, Taylor, Taylor, Whalley, Wilson, Wilson   +62 more
core   +1 more source

Language impairments in ALS/MND (Amyotrophic Lateral Sclerosis/Motor Neuron Disease) [PDF]

, 2002
Paolo Bongioanni §, Giancarlo Buoiano C§, Marzia Magoni § § Neuroscience Dpt., Univ. Of Pisa, Italy c Corresponding author: Giancarlo Buoiano Via del Morello 8 Bargecchia I-55040 Corsanico (LU) email: giancarlo@neurolinguistics.0catch.com Language ...
Bongioanni, Dr. Paolo, Buoiano, Dr. Giancarlo, Magoni, Dr. Marzia   +2 more
core  

Early and Progressive Spinal Cord Atrophy in Spinocerebellar Ataxia Type 1

Movement Disorders, EarlyView.
Abstract Background Spinocerebellar ataxia type 1 (SCA1) is a rare, autosomal dominant neurodegenerative disorder characterized by progressive cerebellar and brainstem degeneration. Previous studies have shown that spinal cord atrophy is also a key aspect of SCA1 neuropathology.
Colette J.M. Reniers, Teije H. van Prooije, Kirsten C.J. Kapteijns, Jack J.A. van Asten, Caterina Mariotti, Lidia Sarro, Anna Nigri, Marina Grisoli, Giulia Coarelli, Alexandra Durr, Tom Scheenen, Bart van de Warrenburg   +11 more
wiley   +1 more source

Biomarkers of Leucine‐Rich Repeat Kinase 2 (LRRK2) and Lysosomal Dysfunction in Progressive Supranuclear Palsy

Movement Disorders, EarlyView.
Abstract Background Common and rare genetic variants in leucine‐rich repeat kinase 2 (LRRK2) have been linked with sporadic and familial Parkinson's disease (PD). Recently, we discovered that common genetic variation near the LRRK2 locus determined survival in progressive supranuclear palsy (PSP).
Louise‐Kristine Nielsen, Joshua L.I. Frost, David P. Vaughan, Raquel Real, Riona Fumi, Marte Theilmann Jensen, Megan Hodgson, Eleanor J. Stafford, Lesley Wu, Olaf Ansorge, Annelies Quaegebeur, Kieren S.J. Allinson, Thomas T. Warner, Zane Jaunmuktane, Anjum Misbahuddin, P. Nigel Leigh, Boyd C.P. Ghosh, Kailash P. Bhatia, Alistair Church, Christopher Kobylecki, Michele T.M. Hu, James B. Rowe, Alan A. Shomo, Danielle L. Graham, Omar S. Mabrouk, Huw R. Morris, Esther M. Sammler, Edwin Jabbari   +27 more
wiley   +1 more source

Whither Neuropathology? [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2003
openaire   +2 more sources

POLG‐Related Parkinsonism with Good Response to Deep Brain Stimulation

Movement Disorders Clinical Practice, EarlyView.
Evdokia Efthymiou, Fabian Büchele, Sujitha Mahendran, Lennart Stieglitz, Bettina Balint   +4 more
wiley   +1 more source

Research status and trends of Piezo1 and brain: A bibliometric analysis

Neuroprotection, EarlyView.
This graphical abstract illustrates the workflow and key findings of the bibliometric analysis of Piezo1 in brain research. The primary results were visually centered on a brain graphic highlighting the Piezo1 channel, and three converging research hotspots were identified: neurovascular regulation, calcium signaling, and neuroinflammation.
Yu Liu, Shengzhen Luo, Hao Zhang, Jianqing Lin, Hui Xiao, Yuying Ma, Dongxue Ye, Liang Cong, Yongwang Li   +8 more
wiley   +1 more source

Pediatric spinal ependymomas: Long‐term surgical outcomes in a cohort of 61 cases

Pediatric Investigation, EarlyView.
Spinal ependymomas are rare in children, with limited long‐term outcome data. In this retrospective study of 61 pediatric patients undergoing surgical resection, gross total resection was achieved in 62.3% and was associated with favorable functional improvement. Recurrence was observed in 31.1% of cases.
Liang Zhang, Xingyu Liu, Bo Han, Wenqing Jia   +3 more
wiley   +1 more source

Neuropathologic findings and age‐related differences in Finnish pediatric medico‐legal autopsies

Journal of Forensic Sciences, EarlyView.
Abstract Neuropathological examination plays a critical role in medico‐legal cause‐of‐death investigation, especially in determining the cause and manner of death in pediatric autopsies. Although a comprehensive neuropathological examination is recommended, limited data exists of the diagnostic yield of neuropathology consultations in such cases.
Elias Hakanen, Petteri Oura, Paula Katriina Vauhkonen   +2 more
wiley   +1 more source