Results 231 to 240 of about 171,935 (300)

MET fusions and splicing variants in glioma: a landscape integrating clinical, pathological, and survival features

The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.
Abstract MET alterations, including MET fusions and splicing variants (F/SVs), are linked to glioma progression, but the clinical features remain underexplored since the 2021 WHO classification of tumors of the CNS. We aimed to systematically depict the MET F/SVs and patient characteristics in a multicenter cohort focusing on clinical, pathological ...
Zheng Fang, Chengjun Zheng, Peng Wang, Xing Liu, Lingyu Liu, Guanzhang Li, Jiahan Dong, Qiaodong Chen, Delong Zhang, Yutong Feng, Ying Zhang, Zhaoshi Bao   +11 more
wiley   +1 more source

Immunohistochemical Analysis of Tom20 in Choroid Plexus Epithelial Cells From Elderly Brains With Neurodegenerative Diseases. [PDF]

Neuropathology
Murakami R, Chiba Y, Miyai Y, Matsumoto K, Wakamatsu K, Saito Y, Hara M, Murayama S, Ueno M.   +8 more
europepmc   +1 more source

HISTAI: a valuable dataset with a valuable lesson

The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.
Abstract The application of artificial intelligence in computational pathology depends on both robust algorithms and high‐quality, clinically reliable data. Progress in this field has been limited by the scarcity of large, diverse, and well‐validated whole slide image (WSI) datasets.
Katherine J Hewitt, Nic G Reitsam, Sebastian Foersch, Ramona Erber, Qinghe Zeng, Jakob Nikolas Kather   +5 more
wiley   +1 more source

Editorial: Meeting new challenges in translationally relevant neurodegenerative disease research

Frontiers in Neuroscience
Caitlin Shannon Latimer, Zainuddin Quadri, David G. Cook, David G. Cook, David G. Cook   +4 more
doaj   +1 more source

NAD+‒circadian rhythm coupling in dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang, Jiyeon Lee, Jun‐ping Pan, Rune Enger, Harald Hrubos‐Strøm, Erik S. Musiek, Evandro Fei Fang, Weidong Le   +7 more
wiley   +1 more source

GPND‐AI NULISA: A 15‐Protein AI classifier for diagnosis and co‐pathology profiling across neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Accurate clinical diagnosis of neurodegenerative diseases remains challenging, particularly when individuals have mixed pathologies. We implemented the generalizable protein‐based neurodegenerative disease artificial intelligence (GPND‐AI) classifier using the NUcleic acid‐Linked Immuno‐Sandwich Assay (NULISA) central nervous ...
Ying Xu, Marisa N Denkinger, Menghan Liu, Katherine Gong, Yike Chen, Daniel Western, Jigyasha Timsina, Yuchen Cheng, Yunchang Xie, Rui Mu, John Budde, Thomas G. Beach, Geidy E. Serrano, Eric M. Reiman, Alpana Singh, Isabel Alfradique‐Dunham, Tammie L. S. Benzinger, Suzanne E. Schindler, John C. Morris, David M. Holtzman, Joel S. Perlumtter, B Joy Snider, Meghan C. Campbell, Paul T. Kotzbauer, Nicholas J. Ashton, Carlos Cruchaga   +25 more
wiley   +1 more source

The shapes of brain waste: Mysteries of cellular remnant morphology in neurodegeneration. [PDF]

Free Neuropathol
Forrest DV.
europepmc   +1 more source

Effects of α‐synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION α‐Synuclein is the hallmark pathology of Parkinson's disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). We investigated effects of α‐syn biomarker positivity in clinically unimpaired (CU) individuals.
Joseph R. Winer, Melanie J. Plastini, America Romero, Hillary Vossler, Isha Sai, Divya Channappa, Carla Abdelnour, Marian Shahid‐Besanti, Edward N. Wilson, Hamilton Se‐Hwee Oh, Christina B. Young, Alexandra Trelle, Maya Yutsis, Sharon J. Sha, Veronica Ramirez, Ryan Taylor, Kyan Younes, Tony Wyss‐Coray, Michael D. Greicius, Victor W. Henderson, Anthony D. Wagner, Kathleen L. Poston, Elizabeth C. Mormino   +22 more
wiley   +1 more source

The Clinical Spectrum and Neurodevelopmental Pathogenesis of KPTN‐Related Disorder in a Mouse Model

Annals of Neurology, Volume 99, Issue 5, Page 1287-1302, May 2026.
Objective Pathogenic variants in Kaptin (KPTN) cause KPTN‐related disorder (KRD). KPTN modulates mTOR signaling activation within the KICSTOR complex in response to cellular amino acid levels. We define the clinical spectrum and investigate the developmental pathogenesis of KRD.
Lettie E. Rawlins, Philip H. Iffland II, John Page, Rebecca Z. Flessner, Soad M. Elziny, Irina Sbornova, Janice K. Babus, Sophie R. Bruckmeier, Ria Parikh, Merel Verhoeven, James Fasham, Joseph S. Leslie, Richard Caswell, Nishanka Ubeyratna, Olivia Wenger, Ethan M. Scott, John Schreiber, Steffen Syrbe, Annick Klabunde‐Cherwon, Martina Owens, Andrew H. Crosby, Emma L. Baple, Peter B. Crino, the KPTN Consortium, Andrea Seeley, Heather Rocha, Sabine Rudnick, Ulrich Schaatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Ian Ellis, Raza Maroofian, Almundher Al‐Maawali, David Coman, Anthony Morosini, Sajjad Biglari, Pooneh Nikuei, Saadet Mercimek‐Andrews, Prab Prabhakar, Raymond Louie, Kameryn Butler, Olivia Wenger, Ethan M. Scott, Andrea Seeley, Heather Rocha, Amber Begtrup, Sabine Rudnik, Ulrich Schatz, Tobias Haack, Eva Schwaibold, Caleb Bupp, Klaas Wierenga, John Schreiber, Thorkild Terkelsen, Sarina Kant, J. C. Herkert, Michael Wright, Boris Keren, Solveig Heide, Pamela Jackson, Pradeep Vasudevan, Helen Stewart, Perrine Charles, Andreas Hahn, Saskia Biskup, Inger‐Lise Mero, Martin Heier, Marijn Stokman, Conny van Ravenswaaij‐Arts, Esther Nibbeling, Stephanie Efthymiou, Erum Afzal, Kristina Zhelcheska, Henry Houlden, Ian Ellis, Reza Maroofian, Gholamreza Shariati, Hamid Galehdari, Almundher Al‐Maawali, Adila Al‐Kindi, Andrew Y. Shuen, Victoria Siu, Annick Klabunde‐Cherwon, Steffen Syrbe   +104 more
wiley   +1 more source