Results 211 to 220 of about 115,701 (249)

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, Volume 36, Issue 6, November 2026.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Sex differences in dementia pathology and cognitive performance in a population-based, ethnically diverse Brazilian autopsy study. [PDF]

Alzheimers Dement
Socher KLR, Ferreira NV, Paes VR, Justo AFO, Rodriguez RD, Silva CM, Leite REP, Ururahy RR, de Moraes FOC, Padrão IL, Ferriolli E, Pasqualucci CA, Nitrini R, Grinberg LT, Brucki SMD, Suemoto CK.   +15 more
europepmc   +1 more source

Editorial: Meeting new challenges in translationally relevant neurodegenerative disease research

Frontiers in Neuroscience
Caitlin Shannon Latimer, Zainuddin Quadri, David G. Cook, David G. Cook, David G. Cook   +4 more
doaj   +1 more source

Multi-modal deep learning and explainable AI for predicting multiple dementia-related neuropathologies from brain MRI, clinical, and genetic data. [PDF]

Front Neurol
Chattopadhyay T, Kush R, Ankarath RH, Senthilkumar P, Gleave EJ, Patterson C, Owens-Walton C, Thomopoulos SI, Johnson SC, Mormino EC, Tosun D, Hohman TJ, Thompson PM.   +12 more
europepmc   +1 more source

Distinct types of PrPres induce different microglial reaction in sporadic Creutzfeldt-Jakob disease

, 2001
AWAN T, ROSSI G, IUSSICH S, PUOTI, Gianfranco, BUGIANI O, PICCINI A, GIACCONE G, TAGLIAVINI F. CONGRESS OF THE AMERICAN ASSOCIATION OF NEUROPATHOLOGY   +7 more
core  

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, Volume 36, Issue 6, November 2026.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Neuropathology in a diverse cohort of oldest-old: The LifeAfter90 study. [PDF]

Alzheimers Dement
Dugger BN, Luu MN, Patel V, DeCarli C, Jin LW, Gilsanz P, Mungas D, Kawas C, Corrada MM, Whitmer RA.   +9 more
europepmc   +1 more source

A novel hierarchical framework elucidating regional differences in α-synuclein and tau co-pathology in military veterans with parkinsonism. [PDF]

J Neuropathol Exp Neurol
Flores Almazan VG, Laborc KF, De Sanctis C, Thorn EL, Goldstein A, Cervera A, Quintana Mora DF, Mendez Y, McGoldrick AC, Chiu LY, Hossain QI, McQuillan S, Lind-Watson K, Walker JM, Walker RH, Nirenberg MJ, Crary JF.   +16 more
europepmc   +1 more source

Exploring the Mechanism of Postpartum Cognitive Dysfunction in a Preeclampsia Rat Model via Multimodal Imaging

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
This schematic illustrates an L‐NAME‐induced preeclampsia (PE) rat model generated via L‐NAME administration to pregnant dams, wherein Morris water maze assessments confirmed progressive postpartum cognitive dysfunction that emerged at 10 days post‐partum and deteriorated further at 1 and 3 months post‐partum. Multimodal magnetic resonance imaging (MRI)
Yong Xia, Junguo Zhao, Bo Gao
wiley   +1 more source