Results 171 to 180 of about 68,153 (255)

Marmoset superior colliculus: neuronal expression of somatostatin but not vasoactive intestinal peptide or neuropeptide Y. [PDF]

Front Neuroanat
Chong MHY, Cho EKL, Rosa MGP, Atapour N.
europepmc   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Neuropeptide Y regulation of dental pulp neurogenic inflammation provoked by tooth bleaching agents: a descriptive comparative clinical study. [PDF]

Restor Dent Endod
Caviedes-Bucheli J, Ríos-Osorio N, Pérez-Villota M, Aucú-Miño K, Escobar-Mafla D, Muñoz-Alvear HD, Gomez-Sosa JF, Diaz-Barrera L, Güiza-Cristancho E, Munoz HR.   +9 more
europepmc   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Dual Targeting Approach Using 4-Hydroxytamoxifen Neuropeptide Y Conjugates for Selective Addressing of Adipose Tissue. [PDF]

ChemMedChem
Kohler A, Jülke EM, Darveniza LC, Stichel J, Beck-Sickinger AG.   +4 more
europepmc   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Topiramate Enhances GABAergic Tone to Orexigenic Neuropeptide Y/Agouti-Related Peptide (NPY/AgRP) Neurons. [PDF]

Obesity (Silver Spring)
Minbashi Moeini M, Lavoie O, Caron A, Williams KW, Michael NJ.   +4 more
europepmc   +1 more source

Microbiome and Metabolomics in Obesity: Advances in Understanding and Interventions Across the Lifespan

Obesity Reviews, EarlyView.
ABSTRACT Obesity arises from intertwined and reciprocal diet‐microbiome‐host pathways that reshape energy balance, insulin sensitivity, and inflammation. This review synthesizes mechanistic links between microbial functions and metabolic control, charts lifestyle‐related lifecourse dynamics from birth to older age, examines how GLP‐1‐based therapies ...
Ioanna Panagiota Kalafati, David Krongauz, Alice Bosco, Antonio Noto, Cristina Piras, Maria Kafyra, Angelica Dessì, Matteo Mauri, Luigi Atzori, Adina Weinberger, Vassilios Fanos, George V. Dedoussis, on behalf of the BETTER4U consortium   +12 more
wiley   +1 more source

Intranasal Application of Peptides Modulating the Neuropeptide Y System. [PDF]

ACS Pharmacol Transl Sci
Jülke EM, Özbay B, Nowicki M, Els-Heindl S, Immig K, Mörl K, Bechmann I, Beck-Sickinger AG.   +7 more
europepmc   +1 more source

Transcriptome Analysis Reveals Distinct Molecular Signatures Between Erosive and Non‐Erosive Oral Lichen Planus

Oral Diseases, EarlyView.
ABSTRACT Objectives To identify molecular mechanisms distinguishing the erosive subtype of oral lichen planus (EOLP) from the non‐erosive subtype (NEOLP) through transcriptomic analysis. Methods We analysed bulk RNA‐seq data from 30 buccal mucosa samples (13 EOLP, 17 NEOLP) using differential expression, Gene Set Enrichment Analysis (GSEA ...
Kisung Sheen, Chaerim Song, Kanghyun Kwon, Seoyeon Kim, Hye‐Ji Park, Man S. Kim   +5 more
wiley   +1 more source