Results 181 to 190 of about 64,926 (256)

Reduced cardiovascular mortality at moderate altitude: a putative role of physical activity and body mass

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet   +6 more
wiley   +1 more source

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord. [PDF]

open access: yesNat Commun
Zeng Q   +11 more
europepmc   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck   +13 more
wiley   +1 more source

Intrinsic pH chemosensitivity of acutely dissociated medullary serotonergic and retrotrapezoid neurones

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Central respiratory chemoreceptors (CRCs) are critical for maintaining normal systemic levels of pH and PCO2. A CRC must respond to pH via intrinsic mechanisms. Here we quantified intrinsic chemosensitivity of medullary 5‐HT neurones and retrotrapezoid nucleus (RTN) neurones using acute dissociation.
Yuanming Wu   +2 more
wiley   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu   +5 more
wiley   +1 more source

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