Results 11 to 20 of about 68,153 (255)

Neuropeptide Y regulates proliferation and apoptosis in granulosa cells in a follicular stage-dependent manner

Journal of Ovarian Research, 2020
Background The complex regulatory mechanism involved in ovarian follicular development is not completely understood. Neuronal neuropeptide Y (NPY) is involved in the regulation of feeding behavior, energy homeostasis, and reproduction behavior, while its
Yoko Urata, Reza Salehi, Patricia D. A. Lima, Yutaka Osuga, Benjamin K. Tsang   +4 more
doaj   +1 more source

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Neurobiology of Disease, 2012
We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats.
Casper R. Gøtzsche, Litsa Nikitidou, Andreas T. Sørensen, Mikkel V. Olesen, Gunnar Sørensen, Søren H.O. Christiansen, Mikael Ängehagen, David P.D. Woldbye, Merab Kokaia   +8 more
doaj   +1 more source

Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state

Cell Communication and Signaling, 2020
Background A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and internalization into ...
Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl, Annette G. Beck-Sickinger   +4 more
doaj   +1 more source

Neuropeptide Y directly reduced apoptosis of granulosa cells, and the expression of NPY and its receptors in PCOS subjects

Journal of Ovarian Research, 2023
Background Most women with anovulatory infertility show polycystic ovarian syndrome (PCOS), and androgen excess is known as a key factor involved in pathogenicity of PCOS.
Yoko Urata, Reza Salehi, Brandon A. Wyse, Sahar Jahangiri, Clifford L. Librach, Chii-Ruey Tzeng, Yutaka Osuga, Benjamin Tsang   +7 more
doaj   +1 more source

EFFECT OF ALPHA TOCOPHEROL ON CHRONIC STRESS INDUCED DERANGEMENTS INN NEUROPEPTIDEY ON SPRAGUE DAWLEY RATS

Pakistan Armed Forces Medical Journal, 2020
Objective: To determine the chronic stress induced decline in plasma Neuropeptide Y (NPY) level and protective effects of Alpha Tocopherol (AT) on maintenance of Neuropeptide Y level. Study Design: Quasi-experimental study.
Saadia Zainab, Umar Ali Khan, Ghulam Mustafa Lodhi, Munazza Asad   +3 more
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The effect of human wharton’s jelly-derived mesenchymal stem cells on MC4R, NPY, and LEPR gene expression levels in rats with streptozotocin-induced diabetes [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to
Fatemeh Sabet Sarvestani, Mohammad Ali Zare, Forough saki, Farhad Koohpeyma, Ismail H. al-Abdullah, Negar Azarpira   +5 more
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Neuropeptide Y and Epilepsy

Epilepsy Currents, 2003
It is a central tenet of the epilepsy field that seizures result from the imbalance of excitation over inhibition ( 1 ). The bulk of excitation is mediated by the neurotransmitter glutamate, whereas inhibition results mainly from the actions of γ-aminobutyric acid (GABA).
William F., Colmers, Bouchaïb, El Bahh
openaire   +2 more sources

Pharmacogenetic markers of antipsychotic-induced weight gain: leptin and neuroepeptide Y

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2021
Antipsychotic drugs are a critical modality in managing of schizophrenia. Although medications can be highly effective, response varies and some patients derive considerably less benefit than others.
V. S. Dobrodeeva, N. A. Shnayder, K. O. Mironov, R. F. Nasyrova   +3 more
doaj   +1 more source

Correlations of Neuropeptide Y and Adiponectin Serum Levels in Obese Type 2 Diabetics in Relation to Insulin Resistance [PDF]

Al-Anbar Medical Journal
Background The importance of obesity in the progression of Type 2 Diabetes Mellitus (T2DM) is represented by defective biochemical markers' production and release that may interact with each other, resulting in negative outcomes for the diabetic state ...
Nada Hasan, Shatha Ali
doaj   +1 more source

Neuropeptide Y and Stress [PDF]

Psikiyatride Güncel Yaklaşımlar, 2012
The neurobiological aspects of stress and coping skills has been the focus of interest for many researchers. Some of the studies has shown that there is a significant relationship among genetically variables, stress response and life events. Neuropeptide
Murat Gulsun, Lut Tamam, Fatih Ozcelik
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