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Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats.
Endocrinology, 1984Observations that a pancreatic polypeptide-like substance, possibly neuropeptide Y, is present in hypothalamic areas and may coexist with catecholamines prompted evaluation of its role in controlling feeding behavior.
J. Clark +3 more
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Neuropeptide Y, ubiquitous and elusive
Peptides, 2004This paper reviews aspects of NPY research that were emerging in 1985, shortly after the isolation and characterization of the peptide. NPY had become known for its widespread distribution especially in the central and peripheral nervous systems, but also in the gastro-intestinal and respiratory tracts and in fibers innervating smooth muscle around ...
Zofia Zukowska, Bibie M Chronwall
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2006
Neuropeptide Y (NPY) is one of the most abundant peptides found in various brain structures and one of the most evolutionary conserved ones. NPY and its homologs (peptide YY and the pancreatic polypeptides) have been implicated in several biological processes including food intake, anxiety, and depression-related behaviors, neuronal excitability and ...
Yvan Dumont, Rémi Quirion
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Neuropeptide Y (NPY) is one of the most abundant peptides found in various brain structures and one of the most evolutionary conserved ones. NPY and its homologs (peptide YY and the pancreatic polypeptides) have been implicated in several biological processes including food intake, anxiety, and depression-related behaviors, neuronal excitability and ...
Yvan Dumont, Rémi Quirion
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Metabolism and functions of neuropeptide Y
Neurochemical Research, 1996Neuropeptide Y is one of the most abundant neuropeptides in the central and peripheral nervous systems and its sequence is highly conserved among species. A number of key physiological roles for NPY are now emerging, especially in the control of feeding and energy homeostasis. Other physiological actions of NPY are also reviewed.
Anthony J. Turner +1 more
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NEUROPEPTIDE Y IN PHAEOCHROMOCYTOMAS AND GANGLIONEUROBLASTOMAS
The Lancet, 1983Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic ...
A.J. Bacarese-Hamilton +6 more
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Neuropeptide Y distribution in the rat brain.
Science, 1983A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family.
Y. Allen +6 more
semanticscholar +1 more source
Neurobehavioral profile of neuropeptide Y
Brain Research Bulletin, 1991In order to better delineate the profile of central actions of neuropeptide Y (NPY), the effects of intracerebroventricular administration of several doses (2.5-20 micrograms) of the peptide on spontaneous activity, muscular tone, body temperature, food intake, nociception and cataleptic manifestations were examined in rats.
Jean-Nil Michaud +6 more
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Introduction to the reviews on neuropeptide Y
Neuropeptides, 2004Neuropeptide Y (NPY) was first reported as an abundant peptide in brain tissue in 1982. Shortly thereafter, NPY was found to be a member of a peptide family consisting of the endocrine peptides pancreatic polypeptide (PP) and peptide YY (PYY). These peptides exert most of their biological effects through five G-protein coupled receptors termed Y1, Y2 ...
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Renal effects of neuropeptide Y
Pfl�gers Archiv European Journal of Physiology, 1998Neuropeptide Y (NPY) is a co-transmitter of the sympathetic nervous system including the renal nerves. The kidney expresses NPY receptors, which can also be activated by peptide YY (PYY), a circulating hormone released from gastrointestinal cells. Five subtypes of NPY receptors have been cloned, among which Y1, Y2 and Y5 appear to be involved in the ...
Angela Bischoff, Martin C. Michel
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Drug Development Research, 1990
AbstractNeuropeptide Y (NPY) has a broad distribution and numerous physiological functions in the peripheral and central nervous systems. The gene transcription and fundamentals of peptide processing have been elucidated. NPY levels and release are exquisitely sensitive to pharmacological and physiological manipulation.
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AbstractNeuropeptide Y (NPY) has a broad distribution and numerous physiological functions in the peripheral and central nervous systems. The gene transcription and fundamentals of peptide processing have been elucidated. NPY levels and release are exquisitely sensitive to pharmacological and physiological manipulation.
openaire +2 more sources