Results 81 to 90 of about 103,228 (328)

Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y [PDF]

International Journal of Basic Science in Medicine, 2019
Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates ...
Vahid Azizi, Shahrbanoo Oryan, Homayuon Khazali, Abdolkarim Hosseini   +3 more
doaj   +1 more source

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

Regulatory Role of FGL‐1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.
Kunihiro Otsuka, Aya Ushio, Ruka Nagao, Shigefumi Matsuzawa, Rieko Arakaki, Kazuki Fukuta, Yasuhiro Mouri, Takaaki Tsunematsu, Naozumi Ishimaru   +8 more
wiley   +1 more source

Arcuate nucleus homeostatic systems reflect blood leptin concentration but not feeding behaviour during scheduled feeding on a high-fat diet in mice [PDF]

, 2017
Acknowledgements T.B. was funded by a CASE studentship from the BBSRC and AstraZeneca. J.B. was a summer student from Bordeaux Sciences Agro and funded by student laboratory experience grant from the British Society of Neuroendocrinology. The authors are
Bake, T., Baron, J., Duncan, J. S., Mercer, J. G., Morgan, D. G. A.   +4 more
core   +1 more source

Physics of Protein Aggregation in Normal and Accelerated Brain Aging

BioEssays, Volume 47, Issue 8, August 2025.
Soluble monomeric proteins precipitate via nucleation into insoluble amyloids in response to age‐related exposures (e.g., microbes, nanoparticles). Persistent soluble‐to‐insoluble phase transition depletes the functional proteins. In normal aging, replacement matches loss; in accelerated aging, it does not.
Alberto J. Espay, Andrea Sturchio, Alberto Imarisio, Emily J. Hill, Brady Williamson, Kora Montemagno, Christian Hoffmann, Hugo Le Roy, Dragomir Milovanovic, Fredric P. Manfredsson   +9 more
wiley   +1 more source

PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]

, 2020
Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W, Gao, Feng, Ji, Haofeng, Kupiec-Weglinski, Jerzy W, Liu, Yuanxing, Shen, Xiu-da, Xue, Zhengze, Zhang, Cheng, Zhang, Yu, Zheng, Shusen   +9 more
core  

Leptin Activates Anorexigenic POMC Neurons through a Neural Network in the Arcuate Nucleus [PDF]

, 2001
The administration of leptin to leptin-deficient humans, and the analogous Lepob/Lepob mice, effectively reduces hyperphagia and obesity. But common obesity is associated with elevated leptin, which suggests that obese humans are resistant to this ...
A Csiffary, AA Butler, C Broberger, CF Elias, D Spanswick, IS Farooqi, James L. Smart, JE Powis, JI Young, JL Halaas, K Lee, KBJ Franklin, LA Campfield, MA Cowley, Malcolm J. Low, Marcelo G. Cerdán, Marcelo Rubinstein, Michael A. Cowley, MJ Kelly, ML Hakansson, MS Kim, P Grieco, PJ King, RD Cone, RM Slugg, Roger D. Cone, Sabrina Diano, SP Kalra, SR Glaum, T Shiraishi, Tamas L. Horvath, TL Horvath, TL Horvath, WG Haynes, WG Haynes, Y Zhang   +35 more
core   +2 more sources

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn [PDF]

, 2017
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and ...
Todd, Andrew J.
core   +1 more source