Results 231 to 240 of about 212,465 (393)

Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism

open access: yesThe FEBS Journal, Volume 292, Issue 8, Page 2017-2050, April 2025.
SUCNR1, activated by succinate, is a Gi‐ and Gq‐coupled receptor present at the plasma membrane and in endosomes. There are conflicting reports about the pro‐/anti‐inflammatory effects of the succinate‐SUCNR1 signaling axis, and these are likely due to localization‐dependent signaling.
Aenne‐Dorothea Liebing   +11 more
wiley   +1 more source

Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake

open access: yesThe FEBS Journal, EarlyView.
Estrogen is regulated by the rate‐limiting enzyme aromatase. This study examines how neuroestrogens, estrogen produced in the brain, regulate appetite through the hypothalamus. Using ovariectomized, aromatase knockout, and brain‐specific aromatase‐restored mice, the study found that neuroestrogens suppress appetite by influencing genes like Mc4r.
Takanori Hayashi   +8 more
wiley   +1 more source

Neuropeptide Y (NPY) potentiates phenylephrine-induced mitogen-activated protein kinase activation in primary cardiomyocytes via NPY Y5 receptors

open access: bronze, 2000
Corinne Pellieux   +6 more
openalex   +1 more source

A pool of Y2 neuropeptide Y receptors activated by modifiers of membrane sulfhydryl or cholesterol balance [PDF]

open access: bronze, 2002
Steven L. Parker   +3 more
openalex   +1 more source

A post hoc analysis of migraine‐associated symptoms from the phase 3 randomized, double‐blind, sham‐controlled Trial of External trigeminal nerve stimulation for the Acute treatment of Migraine (TEAM) study

open access: yesHeadache: The Journal of Head and Face Pain, Volume 65, Issue 5, Page 779-790, May 2025.
Abstract Background The Trial of External trigeminal nerve stimulation (eTNS) for the Acute treatment of Migraine (TEAM) study demonstrated that eTNS use during active migraine resulted in significantly higher rates of resolution of migraine‐associated most bothersome symptom (MBS) compared to sham.
Gregory A. Panza   +2 more
wiley   +1 more source

Low serum 25‐hydroxyvitamin D levels in migraine are not related to headache frequency: A case‐control study in patients with high‐frequency/chronic migraine

open access: yesHeadache: The Journal of Head and Face Pain, Volume 65, Issue 5, Page 863-870, May 2025.
Abstract Background Serum 25‐hydroxyvitamin D (25[OH]D) concentrations have been shown to be low in patients with migraine, but results are controversial regarding the current role of vitamin D in migraine severity. Using a case–control design, we aimed to evaluate serum 25(OH)D levels in a group of females with high‐frequency episodic migraine/chronic
Marina Haro   +6 more
wiley   +1 more source

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