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Analysis of Anxiety Disorders and Post-Traumatic Stress Disorders for Screening Anxiolytic Drugs and Linking Preclinical and Clinical Research. [PDF]

Int J Mol Sci
Kozłowska A, Ma WJ, Shyu BC, Huang ACW.
europepmc   +1 more source

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Neuropeptide Y Receptor Subtypes, Y1 and Y2

Annals of the New York Academy of Sciences, 1990
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, where NPY (and PYY) can exert three types of action: 1) a direct (e.g., vasoconstrictor) response; 2) a postjunctional potentiating effect on NE-evoked vasoconstriction; and 3) a prejunctional suppression of stimulated NE ...
Claes Wahlestedt, Gregory H. Shen, Lars Grundemar, Markus Heilig, Donald J. Reis, Rolf Håkanson, Zofia Zukowska-Grojec   +6 more
openaire   +4 more sources

Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues

Progress in Neurobiology, 1992
Yvan Dumont, Serge St-Pierre, Jean-Claude Martel, Rémi Quirion, Alain Fournier   +4 more
openaire   +4 more sources

Neuropeptide Y receptor subtypes

Life Sciences, 1995
Neuropeptide Y (NPY) is an amidated 36-amino acid peptide with a wide distribution in the central and peripheral nervous system. It can evoke numerous physiological responses by activating specific receptors. Studies using NPY analogs in various model systems and cell types demonstrate different orders of ligand potency and receptor binding affinity ...
Chok P. Wan, Benjamin H.S. Lau
openaire   +3 more sources

The G-protein-coupled neuropeptide Y receptor type 2 is highly dynamic in lipid membranes as revealed by solid-state NMR spectroscopy.

Chemistry, 2014
In spite of the recent success in crystallizing several G-protein-coupled receptors (GPCRs), a comprehensive biophysical characterization of these molecules under physiological conditions also requires the study of the molecular dynamics of these ...
P. Schmidt, L. Thomas, Paul Müller, H. Scheidt, D. Huster   +4 more
semanticscholar   +1 more source

Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus.

Neuroendocrinology, 1997
The arcuate nucleus of the hypothalamus houses a number of neurochemically different cell populations. Among these, a dense cluster of small neuropeptide-Y (NPY)-expressing neurons is located in its ventromedial subdivision and a pro-opiomelanocortin ...
C. Broberger, M. Landry, H. Wong, John N. Walsh, T. Hökfelt   +4 more
semanticscholar   +1 more source

Neuropeptide Y receptor antagonists in obesity

Expert Opinion on Investigational Drugs, 1997
Neuropeptide Y (NPY) is a 36 amino acid amidated peptide with high sequence homology to the endocrine peptides, peptide YY (PYY) and pancreatic polypeptide (PP). They appear to interact with a family of receptors that possess high affinity for one or more of these peptides.
Donald R. Gehlert, Philip Arthur Hipskind   +1 more
openaire   +3 more sources

Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation.

Genomics, 1997
The human y1 and y5 receptor genes are transcribed in opposite directions from a common promoter region on chromosome 4q31-q32. One of the alternately spliced 5' exons of the y1 receptor gene (1C) is also an integral part of the coding region of a novel ...
Herbert Herzog, Karen Darby, Helen J. Ball, Y. Hort, Annette G. Beck-Sickinger, John Shine   +5 more
semanticscholar   +1 more source