Results 341 to 350 of about 212,465 (393)

Neuropeptide Y Y1 receptors in vascular pharmacology

European Journal of Pharmacology, 1998
The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves.
Jan Liska, Anders Franco-Cereceda
openaire   +2 more sources

The control of bone remodeling by neuropeptide Y receptors

Peptides, 2007
An important role for the neuropeptide Y receptor system in the regulation of bone formation was recently revealed with a significant elevation in trabecular bone formation and bone volume following germline or hypothalamus-specific deletion of neuropeptide Y2 receptors in mice.
Susan J. Allison, Herbert Herzog, Paul A. Baldock   +2 more
openaire   +3 more sources

Neuropeptide Y as a partial agonist of the Y1 receptor

European Journal of Pharmacology, 2005
In absence of receptor cycling, human/rat neuropeptide Y was found to persistently occupy the guinea pig neuropeptide Y Y1 receptors expressed on the surface of Chinese hamster ovary (CHO) cells (IC50 approximately 8 nM); a lasting occupancy was also evident with active receptor cycling.
Michael S. Parker, Floyd R. Sallee, Renu Sah, Ambikaipakan Balasubramaniam, Steven L. Parker   +4 more
openaire   +3 more sources

Galanin receptor/neuropeptide y receptor interactions in the central nervous system.

Current protein and peptide science, 2013
The presence of Galanin and Neuropeptide Y and/or their receptors in several areas of the brain involved in memory, mood, cardiovascular control and food intake indicates that Galanin, and Neuropeptide Y could equilibrate the physiological actions of ...
Z. Díaz-Cabiale, A. Flores-Burgess, C. Parrado, M. Narváez, C. Millón, A. Puigcerver, R. Coveñas, K. Fuxe, J. Narváez   +8 more
semanticscholar   +1 more source

Neuropeptide Y receptor gene y6: multiple deaths or resurrections?

Biochemical and Biophysical Research Communications - BBRC, 2000
The neuropeptide Y family of G-protein-coupled receptors consists of five cloned members in mammals. Four genes give rise to functional receptors in all mammals investigated.
P. Starbäck, A. Wraith, H. Eriksson, Dan Larhammar   +3 more
semanticscholar   +1 more source

Effect of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246 on neuropeptide Y release

European Journal of Pharmacology, 2000
We have examined the selective neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl]cyclopentyl]acetyl ]-N-[2-[1 ,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3-H-1,2, 4-triazol-4-yl]ethyl]-argininamid (BIIE0246) on neuropeptide release from rat hypothalamic slices in vitro.
Peter S. Widdowson, Gareth Williams, Peter King, Henri Doods   +3 more
openaire   +3 more sources

Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor

European Journal of Pharmacology, 1996
To elucidate which neuropeptide Y receptor subtype is responsible for the neuropeptide Y-induced potentiation of the noradrenaline-evoked contraction in human omental arteries we used antisense oligodeoxynucleotide (Antisense), the new selective neuropeptide Y Y1 receptor antagonist, BIBP3226 {(R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-D ...
Torun Nilsson, Torun Nilsson, Anders Bergdahl, Anders Bergdahl, David Erlinge, David Erlinge, T. Hedner, Leif Nilsson, Leif Nilsson, X.Y. Sun, Leonor Cantera, Leonor Cantera, Stig Valdemarson, Stig Valdemarson, Lars Edvinsson, Lars Edvinsson   +15 more
openaire   +3 more sources

Incorporation of ortho-carbaboranyl-Nε-modified L-lysine into neuropeptide Y receptor Y1- and Y2-selective analogues.

Journal of Medicinal Chemistry, 2011
Nontoxic ortho-carbaborane is one of the most promising structure for boron neutron capture therapy (BNCT). For directed uptake of ortho-carbaborane by tumor cells, receptor-subtype selective neuropeptide Y (NPY) and its derivatives were modified with ...
Verena M. Ahrens, René Frank, S. Stadlbauer, A. Beck‐Sickinger, E. Hey‐Hawkins   +4 more
semanticscholar   +1 more source

Emerging functions of neuropeptide Y Y2 receptors in the brain

Peptides, 2001
The Y(2) receptor is the predominant neuropeptide Y (NPY) receptor subtype in the brain. Y(2) receptor mRNA is discretely distributed in the brain, including specific subregions of the hippocampus and the hypothalamus, and is largely consistent with the distribution of Y(2) receptor protein demonstrated by radioligand-binding methods.
Akio Inui, Toshiro Kaga, Mineko Fujimiya
openaire   +3 more sources

Pharmacological characterization of the cloned neuropeptide Y y6 receptor

European Journal of Pharmacology, 2000
Neuropeptide Y has potent appetite stimulating effects which are mediated by hypothalamic receptors believed to be of the neuropeptide Y Y(1) and/or neuropeptide Y Y(5) subtype. In mice, the neuropeptide Y y(6) receptor is also expressed in the hypothalamus, suggesting that it too may function as a feeding receptor in this species. Several laboratories
Mario Guzzi, Deborra E Mullins, Ling Xia, Eric M. Parker   +3 more
openaire   +3 more sources