Results 241 to 250 of about 21,634,263 (295)

Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues

Peptides, 2002
mRNA encoding the human NPY Y1 and NPY Y2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, the trigeminal and superior cervical ganglia were positive for both receptors.
Rolf, Uddman, Sebastian, Möller, Torun, Nilsson, Susanne, Nyström, Jonas, Ekstrand, Lars, Edvinsson   +5 more
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Neuropeptide y receptor in bovine hippocampus is a Y2 receptor

Life Sciences, 1992
[125I]NPY bound to a single class of saturable binding sites on bovine hippocampus membranes with a KD of 0.1 mM and Bmax of 165 fmol/mg of protein. The rank order of potency of NPY fragments and other structurally related peptides to inhibit [125I]NPY binding was: PYY greater than or equal to NPY much greater than BPP greater than or equal to APP and ...
W, Li, R G, MacDonald, T D, Hexum
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Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists

Bioorganic & Medicinal Chemistry Letters, 2002
Dihydropyridine 5a was found to be an inhibitor of neuropeptide Y(1) binding in a high throughput (125)I-PYY screening assay. Structure-activity studies around certain portions of the dihydropyridine chemotype identified BMS-193885 (6e) as a potent and selective Y(1) receptor antagonist.
Graham S, Poindexter, Marc A, Bruce, Karen L, LeBoulluec, Ivo, Monkovic, Scott W, Martin, Eric M, Parker, Larry G, Iben, Rachel T, McGovern, Astrid A, Ortiz, Jennifer A, Stanley, Gail K, Mattson, Michael, Kozlowski, Meredith, Arcuri, Ildiko, Antal-Zimanyi   +13 more
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Modulation of neuropeptide Y receptors for the treatment of obesity

Expert Opinion on Therapeutic Patents, 2009
Neuropeptide Y (NPY) has been demonstrated to have critical roles in the physiological control of appetite and energy homeostasis through NPY Y1, Y2, Y4 and Y5 receptors. A number of synthetic ligands for NPY receptor subtypes have been developed to date, with Y5 receptor antagonists and Y2 and Y4 receptor agonists advancing into clinical trials.A ...
Nagaaki, Sato, Yoshio, Ogino, Satoshi, Mashiko, Makoto, Ando   +3 more
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The control of bone remodeling by neuropeptide Y receptors

Peptides, 2007
An important role for the neuropeptide Y receptor system in the regulation of bone formation was recently revealed with a significant elevation in trabecular bone formation and bone volume following germline or hypothalamus-specific deletion of neuropeptide Y2 receptors in mice.
S J, Allison, P A, Baldock, H, Herzog
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Neuropeptide Y Y1 receptors in vascular pharmacology

European Journal of Pharmacology, 1998
The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves.
A, Franco-Cereceda, J, Liska
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Neuropeptide Y Receptor in Vascular Smooth Muscle

Journal of Neurochemistry, 1991
Abstract: 125I‐Bolton‐Hunter (125I‐BH) neuropeptide Y (NPY) was used to identify specific high‐affinity NPY binding sites in porcine aortic smooth muscle membrane fractions and to characterize the binding sites in comparison with those in porcine hippocampal membrane fractions.
Y, Shigeri, S, Mihara, M, Fujimoto
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Neuropeptide Y as a partial agonist of the Y1 receptor

European Journal of Pharmacology, 2005
In absence of receptor cycling, human/rat neuropeptide Y was found to persistently occupy the guinea pig neuropeptide Y Y1 receptors expressed on the surface of Chinese hamster ovary (CHO) cells (IC50 approximately 8 nM); a lasting occupancy was also evident with active receptor cycling.
Renu, Sah, Ambikaipakan, Balasubramaniam, Michael S, Parker, Floyd, Sallee, Steven L, Parker   +4 more
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Sequence and Expression of a Neuropeptide Y Receptor cDNA

Molecular Pharmacology, 1991
The polymerase chain reaction was used to isolate novel GTP-binding protein (G protein)-coupled receptors from bovine locus coeruleus (LC), a brain region enriched in the neuropeptide Y (NPY) system, using degenerate primers derived from the third and sixth transmembrane domains of known G protein-coupled receptors.
J, Rimland, W, Xin, P, Sweetnam, K, Saijoh, E J, Nestler, R S, Duman   +5 more
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Neuropeptide Y Receptor Subtypes, Y1 and Y2

Annals of the New York Academy of Sciences, 1990
Heterogeneity among NPY (and PYY) receptors was first proposed on the basis of studies on sympathetic neuroeffector junctions, where NPY (and PYY) can exert three types of action: 1) a direct (e.g., vasoconstrictor) response; 2) a postjunctional potentiating effect on NE-evoked vasoconstriction; and 3) a prejunctional suppression of stimulated NE ...
C, Wahlestedt, L, Grundemar, R, Håkanson, M, Heilig, G H, Shen, Z, Zukowska-Grojec, D J, Reis   +6 more
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