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Neuropeptide Y receptor antagonists
Expert Opinion on Therapeutic Patents, 1999On the basis of pharmacological observations, neuropeptide Y (NPY) has been implicated to be involved in numerous physiological functions. Preliminary results suggest a wide therapeutic utility for NPY antagonists in disorders such as anxiety, appetite stimulation, obesity, alcohol intake, hypertension, and regulation of coronary tone. This review will
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Effect of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246 on neuropeptide Y release
European Journal of Pharmacology, 2000We have examined the selective neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b, e]azepin-11-yl]-1-piperazinyl]-2-oxoethyl]cyclopentyl]acetyl ]-N-[2-[1 ,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3-H-1,2, 4-triazol-4-yl]ethyl]-argininamid (BIIE0246) on neuropeptide release from rat hypothalamic slices in vitro.
P J, King +3 more
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Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor
European Journal of Pharmacology, 1996To elucidate which neuropeptide Y receptor subtype is responsible for the neuropeptide Y-induced potentiation of the noradrenaline-evoked contraction in human omental arteries we used antisense oligodeoxynucleotide (Antisense), the new selective neuropeptide Y Y1 receptor antagonist, BIBP3226 {(R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-D ...
A, Bergdahl +8 more
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Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues
Progress in Neurobiology, 1992Y, Dumont +4 more
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Neuropeptide Y receptors in pig spleen
Acta Physiologica Scandinavica, 1987A, Härfstrand, J M, Lundberg, K, Fuxe
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Neuropeptide Y receptor antagonists.
IDrugs : the investigational drugs journal, 2005A review of the patent literature for neuropeptide Y (NPY) antagonists is presented for the period of January 2000 to March 2001. This review focuses on antagonists of the Y(1) and Y(5) receptor subtypes, which have been of primary interest as anti-obesity agents.
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