Results 321 to 330 of about 206,368 (387)

Neuropeptide Y receptor subtypes

Life Sciences, 1995
Neuropeptide Y (NPY) is an amidated 36-amino acid peptide with a wide distribution in the central and peripheral nervous system. It can evoke numerous physiological responses by activating specific receptors. Studies using NPY analogs in various model systems and cell types demonstrate different orders of ligand potency and receptor binding affinity ...
Chok P. Wan, Benjamin H.S. Lau
openaire   +3 more sources

Neuropeptide Y receptor antagonists in obesity

Expert Opinion on Investigational Drugs, 1997
Neuropeptide Y (NPY) is a 36 amino acid amidated peptide with high sequence homology to the endocrine peptides, peptide YY (PYY) and pancreatic polypeptide (PP). They appear to interact with a family of receptors that possess high affinity for one or more of these peptides.
Donald R. Gehlert, Philip Arthur Hipskind   +1 more
openaire   +3 more sources

Neuropeptide Y Receptors

, 2008
M. Michel
semanticscholar   +2 more sources

Intracellular Trafficking of Neuropeptide Y Receptors

2015
The multireceptor multiligand system of neuropeptide Y receptors and their ligands is involved in the regulation of a multitude of physiological and pathophysiological processes. Specific expression patterns, ligand-binding modes, and signaling properties contribute to the complex network regulating distinct cellular responses.
Annette G. Beck-Sickinger, Karin Mörl
openaire   +2 more sources

Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y

International Endodontic Journal, 2010
Killough SA, Lundy FT, Irwin CR. Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y. International Endodontic Journal, 43, 835–842, 2010.AbstractAim  To investigate whether dental pulp fibroblasts express neuropeptide Y (NPY) and NPY‐Y1 in vitro and to determine the effects of the cytokines including interlukin‐1β (IL‐1β)
Killough, S. A., Lundy, F. T., Irwin, C. R.   +2 more
openaire   +4 more sources

Neuropeptide y receptor in bovine hippocampus is a Y2 receptor

Life Sciences, 1992
[125I]NPY bound to a single class of saturable binding sites on bovine hippocampus membranes with a KD of 0.1 mM and Bmax of 165 fmol/mg of protein. The rank order of potency of NPY fragments and other structurally related peptides to inhibit [125I]NPY binding was: PYY greater than or equal to NPY much greater than BPP greater than or equal to APP and ...
Terry D. Hexum, Wei Li, Richard G. MacDonald   +2 more
openaire   +3 more sources

Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIB03304 (Y1) and CGP71683A (Y5).

Canadian Journal of Physiology and Pharmacology, 2000
We have evaluated 3 newly developed neuropeptide Y receptor antagonists in various in vitro binding and bioassays: BIBO3304 (Y1), T4[NPY33-36]4 (Y2), and CGP71683A (Y5).
Y. Dumont, A. Cadieux, H. Doods, A. Fournier, R. Quirion   +4 more
semanticscholar   +1 more source

Neuropeptide Y receptor antagonists

Expert Opinion on Therapeutic Patents, 1999
On the basis of pharmacological observations, neuropeptide Y (NPY) has been implicated to be involved in numerous physiological functions. Preliminary results suggest a wide therapeutic utility for NPY antagonists in disorders such as anxiety, appetite stimulation, obesity, alcohol intake, hypertension, and regulation of coronary tone. This review will
openaire   +2 more sources

GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists

European Journal of Pharmacology, 1998
GR231118, BW1911U90, Bis(31/31')[[Cys31, Trp32, Nva34] neuropeptide Y(31-36)] (T-190) and [Trp-Arg-Nva-Arg-Tyr]2-NH2 (T-241) are peptide analogs of the C-terminus of neuropeptide Y that have recently been shown to be antagonists of the neuropeptide Y Y1 receptor.
Deborra E Mullins, Ling Xia, Mario Guzzi, Eric M. Parker, Gitali Mukhopadhyay, Z. Tao, Fozia Hamud, Melissa A.B. Tice, Robert E. Burrier, Brian G. Salisbury, Ambikaipakan Balasubramaniam, Mark Stephen Rudinski, Carol K Babij   +12 more
openaire   +3 more sources

Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues

Peptides, 2002
mRNA encoding the human NPY Y1 and NPY Y2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, the trigeminal and superior cervical ganglia were positive for both receptors.
Jonas Ekstrand, Torun Nilsson, Sebastian Möller, Lars Edvinsson, Susanne Nyström, Rolf Uddman   +5 more
openaire   +3 more sources