Results 141 to 150 of about 73,747 (293)

Phosphatidylinositol‐4,5‐bisphosphate 3‐kinase (PI3K) inhibitors reduce vascular inflammation in vitro and in vivo

British Journal of Pharmacology, EarlyView.
Background and Purpose Endothelial cells play central roles in increasing vascular permeability and leukocyte recruitment. Therapeutic approaches for treating endothelial cell barrier dysfunction to reduce unwanted fluid accumulation in tissues are limited.
Hiba Chaudhry, Ali A. Zarban, Silvia Cellone Trevelin, Xenia Kodji, Camilla Cerutti, Xiaoqing Xiong, Fulye Argunhan, Ajay M. Shah, Anne J. Ridley, Susan D. Brain   +9 more
wiley   +1 more source

Two- and three-dimensional neuropeptidomic landscape in the central nervous system of an invertebrate chordate, <i>Ciona robusta</i>. [PDF]

iScience
Osugi T, Shiraishi A, Sasakura Y, Sugahara K, Yamagaki T, Yamamoto T, Satake H.   +6 more
europepmc   +1 more source

Target specificity of neuropeptide Y-immunoreactive cranial parasympathetic neurons [PDF]

, 1988
G G Leblanc, SC Landis
openalex   +1 more source

TRPA1 ion channel activation context‐dependently regulates gene expression in normal and psoriatic human skin

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Psoriasis is a chronic, relapsing, immune‐mediated inflammatory skin disease. The transient receptor potential ankyrin 1 (TRPA1) ion channel plays a protective role in the formation of psoriasiform skin reactions. Here, we investigated the pharmacological activation and blockade of TRPA1 in human skin (patho)physiology ...
Ágnes Kemény, Szabina Horváth, Júlia Szebényi, Péter Oláh, Viktória Németh, Péter Urbán, József Kun, Attila Gyenesei, Areej Jaber, Erika Pintér, Rolland Gyulai   +10 more
wiley   +1 more source

Epigenetic modification of hypothalamic neuropeptides and metabolic hormone receptors in metabolic health. [PDF]

Front Endocrinol (Lausanne)
Oladun B, Mall S, Kim MH.
europepmc   +1 more source

Neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH): immunological detection and neuronal localization in insect central nervous system.

, 1981
Clarence A. Bishop, Michael O’Shea, Raymond J. Miller   +2 more
openalex   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Updates in the Treatment of Rosacea with γ-Aminobutyric Acid Derivatives. [PDF]

Clin Cosmet Investig Dermatol
Li D, Yang W, Chen N, Xu Y.
europepmc   +1 more source

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

Epilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones, Silvia Lindlar, Johannes Ludwig, Regina Waltes, Afsheen Kumar, Sophie v. Brauchitsch, Andrea Rossi, Evelyn Ullrich, Stefan Momma, Christine M. Freitag, Jasmin K. Hefendehl, Karl Martin Klein, Felix Rosenow, Denise Haslinger, Andreas G. Chiocchetti   +14 more
wiley   +1 more source

Toward high-efficiency, low-resource, and explainable neuropeptide prediction with MSKDNP. [PDF]

Brief Bioinform
Xie P, Guan J, Zhao Z, Liu Y, Cheng Z, He X, Liu X, Tang Y, Sun Z, Lee TY, Yao L, Chiang YC.   +11 more
europepmc   +1 more source