Influence of neurokinin B, dynorphin A and kisspeptin-10 on <i>in vitro</i> gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes. [PDF]
Szysiak N+7 more
europepmc +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Novel insights into the study of goblet cell hypersecretion in allergic rhinitis. [PDF]
Zhu X, Cheng F, Duan H, Fu S, Zhao C.
europepmc +1 more source
Gastric and sacral electrical stimulation for motility disorders—A clinical perspective
Abstract Background Electrical stimulation of the gut has been investigated in recent decades with a view to treating various gastro‐intestinal motility disorders including, among others, gastric electrical stimulation to relieve nausea and vomiting associated with gastroparesis and sacral neuromodulation to treat fecal incontinence and/or constipation.
Charlotte Desprez+2 more
wiley +1 more source
Molecular Anatomy of Synaptic and Extrasynaptic Neurotransmission Between Nociceptive Primary Afferents and Spinal Dorsal Horn Neurons. [PDF]
Antal M.
europepmc +1 more source
Central mechanisms of emesis: A role for GDF15
Abstract Background Nausea and emesis are ubiquitously reported medical conditions and often present as treatment side effects along with polymorbidities contributing to detrimental life‐threatening outcomes, such as poor nutrition, lower quality of life, and unfavorable patient prognosis.
Tito Borner+2 more
wiley +1 more source
Neuroimmunomodulation in chronic wounds: an opinion. [PDF]
Nardini P, Bacci S.
europepmc +1 more source
Evidence‐based review and frontiers of migraine therapy
Abstract Background Cyclic vomiting syndrome (CVS) is identified as one of the “episodic syndromes that may be associated with migraine,” along with benign paroxysmal torticollis, benign paroxysmal vertigo, and abdominal migraine. It has been proposed that CVS and migraine may share pathophysiologic mechanisms of hypothalamic activation and altered ...
Kaitlin A. Greene+2 more
wiley +1 more source
Pain persists in mice lacking both Substance P and CGRPα signaling. [PDF]
MacDonald DI+5 more
europepmc +1 more source
Endocannabinoid signaling in stress, nausea, and vomiting
Abstract Background Classical antiemetics that target the serotonin system may not be effective in treating certain nausea and vomiting conditions like cyclic vomiting syndrome (CVS) and cannabinoid hyperemesis syndrome (CHS). As a result, there is a need for better therapies to manage the symptoms of these disorders, including nausea, vomiting, and ...
Marieka V. DeVuono+2 more
wiley +1 more source