Results 61 to 70 of about 73,747 (293)

Regulatory Role of FGL‐1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.
Kunihiro Otsuka, Aya Ushio, Ruka Nagao, Shigefumi Matsuzawa, Rieko Arakaki, Kazuki Fukuta, Yasuhiro Mouri, Takaaki Tsunematsu, Naozumi Ishimaru   +8 more
wiley   +1 more source

Neuropeptidergic Regulation of Food Intake in the Neonatal Chick: A Review

The Journal of Poultry Science, 2007
Immediately after hatching, neonatal chicks can find their food and control food intake, but the mechanisms for feeding are not completely understood. Food intake regulation in the brain involves neuropeptides.
Mitsuhiro Furuse, Haruka Yamane, Shozo Tomonaga, Yousuke Tsuneyoshi, D. Michael Denbow   +4 more
doaj   +1 more source

UPLC–ESI–QToF–MS Profile of Hydroalcoholic Extract of Persea cordata (Meisn.) and its Antioedematogenic and Antinociceptive Effects in Mice

Chemistry &Biodiversity, EarlyView.
Hydroalcoholic crude extract of Persea cordata showed in its composition, the presence of lignans based on LCESIMS data. This crude extract displayed anti‐oedematogenic and antinociceptive activities in vivo. Abstract This study aimed to establish the chemical profile and evaluate the anti‐oedematogenic and analgesic activities of the hydroalcoholic ...
Valfredo Schlemper, Daniela Hemsing, Julia Elisabett K. Bolsonello, Susana R. de Mello Schlemper, Tiago Tizziani, Lutuima A. Capangue Neto, Louis P. Sandjo   +6 more
wiley   +1 more source

Role of neuropeptides in patients with endometriosis: a literature review

Middle East Fertility Society Journal
Background This article provides an overview of the role of neuropeptides in endometriosis. Main body. While the pathogenesis of endometriosis is not discovered exactly yet, researchers have explored endocrine, paracrine, and immunological influences to ...
Hamidreza Mosleh, Sedighe Hosseini, Nazanin Hajizadeh, Leila Majdi, Marziyeh Ajdary, Zahra Shams Mofarahe   +5 more
doaj   +1 more source

The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

Chronic Diseases and Translational Medicine, EarlyView.
The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe‐Sheng Chen   +7 more
wiley   +1 more source

Pharmacokinetics, Tolerability, and Biomarker Profile of the Neurokinin 3 Receptor Antagonist Fezolinetant in Healthy Japanese Individuals: A 2‐Part, Randomized, Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This 2‐part, randomized, placebo‐controlled, double‐blind, Phase 1 study analyzed the pharmacokinetics, safety, and biomarker profile of fezolinetant in healthy Japanese individuals. Part 1: male participants received single doses of placebo or fezolinetant 15 or 60 mg.
Akira Koibuchi, Megumi Iwai, Kanji Komatsu, Kentaro Kuroishi, Mai Shibata, Masako Saito, Jace Nielsen, Jiayin Huang, Shunji Matsuki   +8 more
wiley   +1 more source

Safety, Tolerability, and Pharmacokinetics of Galcanezumab, an Anti‐CGRP Antibody, in Healthy Chinese Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Galcanezumab is used in several regions, including the United States, Europe, and China, as a preventive treatment for migraine. This study aimed to evaluate the safety, tolerability, and pharmacokinetics (PK) of galcanezumab in healthy Chinese participants.
Jingjing Wang, Nanyang Li, Jinjie He, Jing Zhang, Lili Wang, William Kielbasa, Chenxi Qian, Yanjie Zhang, Liang Wang   +8 more
wiley   +1 more source

Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy

Neurobiology of Disease, 2020
Neuropeptides are important signalling molecules in the brain and alterations in their expression levels have been linked to neurological disorders such as Parkinson's disease. It is challenging to map neuropeptide changes across and within brain regions
Heather Hulme, Elva Fridjonsdottir, Halla Gunnarsdottir, Theodosia Vallianatou, Xiaoqun Zhang, Henrik Wadensten, Reza Shariatgorji, Anna Nilsson, Erwan Bezard, Per Svenningsson, Per E. Andrén   +10 more
doaj   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Oxytocin Effects on Food Stimulus Processing and Food Intake in Females With or Without Binge Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Binge eating disorder (BED) is maintained by increased food‐related incentive salience, which is reflected by an attentional bias for food. Oxytocin acutely attenuates this bias in patients with anorexia nervosa and reduces food intake in males with normal or increased body weight.
Julia Nannt, Mechteld M. van den Hoek Ostende, Brunna Tuschen‐Caffier, Markus Heinrichs, Daniel Sippel, Manfred Hallschmid, Jennifer Svaldi   +6 more
wiley   +1 more source