Results 61 to 70 of about 45,129 (213)
Andrology, EarlyView.Abstract Background Hypogonadism and infertility are two conditions that are heavily affected by overweight and obesity in the male patient. Glucagon‐like peptide 1 agonists (GLP‐1RAs) are a recently introduced class of antidiabetic drugs with powerful weight‐loss effect; this may induce an indirect positive effect on the testicular function ...
Gianmaria Salvio +6 more
wiley +1 more source
Misses and Near Misses in Paediatric Appendicitis: An Eight‐Year, Single‐Centre Retrospective Review
Acta Paediatrica, EarlyView.ABSTRACT Aim Diagnostic error can result in the appendectomy of a normal appendix, commonly known as negative appendectomy (NA). Missed appendicitis (MA) is related to a poor outcome. The aim of this study was to determine whether there are factors in presentation associated with NA or MA.
Eric Scheier +2 more
wiley +1 more source
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, EarlyView.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo
British Journal of Pharmacology, Volume 182, Issue 9, Page 1975-1988, May 2025.Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome and obesity. Understanding mechanisms of neurogenic control of white adipose tissue is key to understanding adipose physiology and pathophysiology, though there is limited research exploring this in adipose ...
Kayleigh E. Goddard, Samuel J. Fountain
wiley +1 more source
Revisiting the role of Substance P and CGRPα. [PDF]
ElifeCai W, Khoutorsky A.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Binge drinking is a risky pattern of alcohol intake and a major predictor of alcohol use disorder (AUD). Current AUD medications have limited efficacy and poor patient compliance, calling for more effective therapeutics.
Connie J. Badolato +4 more
wiley +1 more source
Insect Mating Behaviors: A Review of the Regulatory Role of Neuropeptides. [PDF]
InsectsOmbuya A, Guo J, Liu W.
europepmc +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Emerging literature indicates that simultaneously targeting glucagon‐like peptide‐1 receptors (GLP‐1Rs) and neuropeptide Y receptors (Y1/Y2) may represent a new pharmacotherapeutic approach to treating opioid use disorder (OUD).
Antonia Caffrey +5 more
wiley +1 more source
Cell Proliferation, EarlyView.The regeneration of LC‐NE from pluripotent stem cells (PSCs) could significantly mitigate the progression of Neurodegenerative diseases and alleviate associated psychiatric disease symptoms, providing a new approach to the treatment of neurological diseases.
Yana Yang, Yunlong Tao
wiley +1 more source