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The role of Neuropilin-1 in vascular development
The role of Neuropilin-1 in vascular developmentopenaire
Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture [PDF]
Structure, 2016 Neuropilins (NRPs) are single-pass transmembrane receptors involved in several signaling pathways that regulate key physiological processes such as vascular morphogenesis and axon guidance. The MAM domain of NRP, which has previously been implicated in receptor multimerization, was the only portion of the ectopic domain of the NRPs for which the ...
Snezana Djordjevic
exaly +4 more sources
Determination of Cell Adhesion Sites of Neuropilin-1 [PDF]
Journal of Cell Biology, 2000 Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neuropilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons.
Fujisawa Hajime, Murakami Yasunori
exaly +3 more sources
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Neuropilin-1 in the Immune System
2002The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class 3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they ...
Paul-Henri, Romeo +2 more
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Serum concentrations of neuropilin-1 in women with endometriosis
Scandinavian Journal of Clinical and Laboratory Investigation, 2020Objective of this work is to investigate, for the first time, serum concentration of neuropilin-1 (NRP-1), aiming to evaluate its diagnostic performance in endometriosis and usability as a potential non-invasive serum marker of endometriosis. Two hundred women were treated laparoscopically. After laparoscopic surgery women were divided into two groups:
Barberić, Monika +3 more
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Neuropilin‐1 expression in cancer and development
The Journal of Pathology, 2011AbstractNeuropilin (NRP)‐1 is a co‐receptor for vascular endothelial growth factor (VEGF). Preclinical data suggest that blockade of NRP1 suppresses tumour growth by inhibiting angiogenesis, in addition to directly inhibiting tumour cell proliferation in certain models. A humanized monoclonal antibody to NRP1 is currently being evaluated as a potential
Adrian M, Jubb +5 more
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Neuropilin 1: function and therapeutic potential in cancer
Cancer Immunology, Immunotherapy, 2013Neuropilin 1 (NRP1) is a transmembrane glycoprotein that acts as a co-receptor for a number of extracellular ligands including class III/IV semaphorins, certain isoforms of vascular endothelial growth factor and transforming growth factor beta. An exact understanding of the role of NRP1 in the immune system has been obscured by the differences in NRP1 ...
Belal, Chaudhary +3 more
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Flow regulation of Neuropilin-1 and the role of Neuropilin-1 in mechanotransduction
2011Le concept de l'angiogénèse est simple et bien défini, comme la formation de nouveaux vaisseaux sanguins à partir de vaisseaux préexistants, mais son mécanisme est complexe, et implique une multitude de facteurs qui sont encore méconnus. Une des choses que nous savons avec certitude, est que l'angiogénèse est une composante vitale de la vie, autant que
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A requirement for neuropilin-1 in embryonic vessel formation
Development, 1999Abstract Neuropilin-1 is a membrane protein that is expressed in developing neurons and functions as a receptor or a component of the receptor complex for the class 3 semaphorins, which are inhibitory axon guidance signals. Targeted inactivation of the neuropilin-1 gene in mice induced disorganization of the pathway and projection of ...
T, Kawasaki +6 more
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Expression of neuropilin-1 in choroidal neovascular membranes
Canadian Journal of Ophthalmology, 2003Neovascularization is a serious consequence of several eye diseases, including age-related macular degeneration. Neovascularization is under the control of proangiogenic factors, such as vascular endothelial growth factor and fibroblast growth factor.
Jing Z, Cui +7 more
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