Results 181 to 190 of about 21,250,288 (213)

Advanced glycation end-products suppress neuropilin-1 expression in podocytes

Kidney International, 2009
Advanced glycation end products (AGEs) have been linked to the pathogenesis of diabetic nephropathy. Here we tested the effect of AGE-modified bovine serum albumin (AGE-BSA) on differentiated mouse podocytes in culture. Differential display and real-time
Tzvetanka Bondeva, Christiane Ruster, Sybille Franke   +2 more
exaly   +2 more sources

Some of the next articles are maybe not open access.

Related searches:

Serum concentrations of neuropilin-1 in women with endometriosis

Scandinavian Journal of Clinical and Laboratory Investigation, 2020
Objective of this work is to investigate, for the first time, serum concentration of neuropilin-1 (NRP-1), aiming to evaluate its diagnostic performance in endometriosis and usability as a potential non-invasive serum marker of endometriosis. Two hundred women were treated laparoscopically. After laparoscopic surgery women were divided into two groups:
Barberić, Monika, Pavičić Baldani, Dinka, Rogić, Dunja, Kralik-Oguić, Saša   +3 more
openaire   +4 more sources

Neuropilin-1 in the Immune System

2002
The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class 3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they ...
Paul-Henri, Romeo, Valérie, Lemarchandel, Rafaele, Tordjman   +2 more
openaire   +2 more sources

Neuropilin‐1 expression in cancer and development

The Journal of Pathology, 2011
AbstractNeuropilin (NRP)‐1 is a co‐receptor for vascular endothelial growth factor (VEGF). Preclinical data suggest that blockade of NRP1 suppresses tumour growth by inhibiting angiogenesis, in addition to directly inhibiting tumour cell proliferation in certain models. A humanized monoclonal antibody to NRP1 is currently being evaluated as a potential
Adrian M, Jubb, Laura A, Strickland, Scot D, Liu, Judy, Mak, Maike, Schmidt, Hartmut, Koeppen   +5 more
openaire   +2 more sources

Neuropilin 1: function and therapeutic potential in cancer

Cancer Immunology, Immunotherapy, 2013
Neuropilin 1 (NRP1) is a transmembrane glycoprotein that acts as a co-receptor for a number of extracellular ligands including class III/IV semaphorins, certain isoforms of vascular endothelial growth factor and transforming growth factor beta. An exact understanding of the role of NRP1 in the immune system has been obscured by the differences in NRP1 ...
Belal, Chaudhary, Yazan S, Khaled, Basil J, Ammori, Eyad, Elkord   +3 more
openaire   +2 more sources

A requirement for neuropilin-1 in embryonic vessel formation

Development, 1999
Abstract Neuropilin-1 is a membrane protein that is expressed in developing neurons and functions as a receptor or a component of the receptor complex for the class 3 semaphorins, which are inhibitory axon guidance signals. Targeted inactivation of the neuropilin-1 gene in mice induced disorganization of the pathway and projection of ...
T, Kawasaki, T, Kitsukawa, Y, Bekku, Y, Matsuda, M, Sanbo, T, Yagi, H, Fujisawa   +6 more
openaire   +2 more sources

Expression of neuropilin-1 in choroidal neovascular membranes

Canadian Journal of Ophthalmology, 2003
Neovascularization is a serious consequence of several eye diseases, including age-related macular degeneration. Neovascularization is under the control of proangiogenic factors, such as vascular endothelial growth factor and fibroblast growth factor.
Jing Z, Cui, Brad J, Hinz, Mark D J, Greve, Michael J, Potter, Dan, Hornan, Arif, Samad, Eleanor, To, Joanne A, Matsubara   +7 more
openaire   +2 more sources

Genetic association of the neuropilin-1 gene with type 1 diabetes in children: Neuropilin-1 expression in pancreatic islets

Diabetes Research and Clinical Practice, 2010
Minor alleles of two SNPs in intron 9 of the NRP1 gene, which encodes neuropilin-1, were found to be associated with type 1 diabetes (T1D) in children. Neuropilin-1 peptides were confined to islets in human pancreas. This suggests neuropilins-1 could influence the development of some cases of T1D in children.
Noaman M, Hasan, Mindy A, Kendrick, Noah R, Druckenbrod, Michael K, Huelsmeyer, Thomas F, Warner, Michael J, MacDonald   +5 more
openaire   +2 more sources

Optimal Saturated Neuropilin-1 Expression in Normal Tissue Maximizes Tumor Exposure to Anti-Neuropilin-1 Monoclonal Antibody

Anti-Cancer Agents in Medicinal Chemistry, 2020
Background:As involved in tumor angiogenesis, Neuropilin Receptor type-1 (NRP-1) serves as an attractive target for cancer molecular imaging and therapy. Widespread expression of NRP-1 in normal tissues may affect anti-NRP-1 antibody tumor uptake.Objective:To assess a novel anti-NRP-1 monoclonal antibody A6-11-26 biodistribution in NRP-1 positive tumor
Chao Ma, Xiaofeng Dou, Jianghua Yan, Shengyu Wang, Rongshui Yang, Fu Su, Huijuan Zhang, Xinhui Su   +7 more
openaire   +2 more sources

The involvement of immune semaphorins and neuropilin-1 in lupus nephritis

Lupus, 2011
Background and objectives: Neuropilin-1 (NP-1), a functional vascular endothelial growth factor (VEGF) receptor, is important in the priming of resting T cells and contributes to the development of peripheral tolerance. Semaphorins, a family of axon guidance molecules, has been found to be involved in regulating the immune system. The
Zahava Vadasz, Ofer Ben-Izhak, J Bejar   +2 more
exaly   +3 more sources