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Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture [PDF]
Structure, 2016 Neuropilins (NRPs) are single-pass transmembrane receptors involved in several signaling pathways that regulate key physiological processes such as vascular morphogenesis and axon guidance. The MAM domain of NRP, which has previously been implicated in receptor multimerization, was the only portion of the ectopic domain of the NRPs for which the ...
Snezana Djordjevic
exaly +4 more sources
Determination of Cell Adhesion Sites of Neuropilin-1 [PDF]
Journal of Cell Biology, 2000 Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neuropilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons.
Fujisawa Hajime, Murakami Yasunori
exaly +3 more sources
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Endothelial neuropilin-1 and neuropilin-2 are essential for tumour angiogenesis
2022Abstract Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known co-receptors for vascular endothelial growth factor receptors (VEGFRs), core drivers of angiogenesis, past investigations have alluded to their functional roles in facilitating tumorigenesis by promoting ...
CJ Benwell +4 more
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Neuropilin-1 in the Immune System
2002The neuropilin-1 (NRP1) and neuropilin-2 (NRP2) receptors can bind the class 3 semaphorin subfamily and the heparin-binding forms of vascular endothelial growth factor (VEGF) and placenta growth factor (PlGF). The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they ...
Paul-Henri, Romeo +2 more
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Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity
Blood, 2008Neuropilin-1 and -2 (NRP1 and NRP2) are the transmembrane glycoproteins interacting with 2 types of ligands: class III semaphorins and several members of the VEGF family, the main regulators of blood and lymphatic vessel growth. We show here that both NRP1 and NRP2 can also bind hepatocyte growth factor (HGF).
Sulpice, Eric +5 more
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Neuropilin‐1 and neuropilin‐2 expression in the adenoma–carcinoma sequence of colorectal cancer
Histopathology, 2013AimsNeuropilin‐1 (NRP1) and neuropilin‐2 (NRP2) are transmembrane glycoproteins which interact with vascular endothelial growth factor (VEGF) to prevent tumour cell apoptosis and regulate angiogenesis. However, the precise role of NRP1 and NRP2 in the adenoma–carcinoma sequence (ACS) of colorectal cancer remains unclear, and we aimed to determine this ...
Malcolm W Reed, Nicola Brown
exaly +3 more sources
Neuropilin‐1 expression in cancer and development
The Journal of Pathology, 2011AbstractNeuropilin (NRP)‐1 is a co‐receptor for vascular endothelial growth factor (VEGF). Preclinical data suggest that blockade of NRP1 suppresses tumour growth by inhibiting angiogenesis, in addition to directly inhibiting tumour cell proliferation in certain models. A humanized monoclonal antibody to NRP1 is currently being evaluated as a potential
Adrian M, Jubb +5 more
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The Interaction of Neuropilin-1 and Neuropilin-2 with Tyrosine-Kinase Receptors for VEGF
2002The Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) receptors were initially described as receptors for axon guidance factors belonging to the class-3 Semaphorin sub-family. Subsequently, it was found the Neuropilins also function as receptors for some forms of vascular endothelial growth factor (VEGF).
Gera, Neufeld +2 more
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Expression and mapping of duplicate neuropilin-1 and neuropilin-2 genes in developing zebrafish
Gene Expression Patterns, 2004Previously, we described the isolation and characterization of the first zebrafish neuropilin gene, which we now call nrp1a, and found its protein to be a mediator of vascular endothelial growth factor (VEGF)-dependent angiogenesis [Proc. Natl Acad. Sci. USA 99 (2002) 10470].
Diane E, Bovenkamp +8 more
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Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors
Nature Neuroscience, 1998Neuropilin-1 (NP-1) has been identified as a necessary component of a semaphorin D (SemD) receptor that repulses dorsal root ganglion (DRG) axons during development. SemA and SemE are related to SemD and bind to NP-1, but do not repulse DRG axons.
T, Takahashi +4 more
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