Results 11 to 20 of about 40,800 (191)

Assessing and Stabilizing Aberrant Neuroplasticity in Autism Spectrum Disorder: The Potential Role of Transcranial Magnetic Stimulation

Frontiers in Psychiatry, 2015
Exciting developments have taken place in the neuroscience research in Autism Spectrum Disorder (ASD) and results from these studies indicate that brain in ASD is associated with aberrant neuroplasticity.
Tarek K Rajji, Stephanie H Ameis
exaly   +3 more sources

The nuclear lamina is a hub for the nuclear function of Jacob

Molecular Brain, 2021
Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR ...
Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz, Anna Karpova   +4 more
doaj   +1 more source

Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease

Translational Neurodegeneration, 2022
Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease.
Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R. Kreutz   +12 more
doaj   +1 more source

A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death

Molecular Brain, 2023
Jacob is a synapto-nuclear messenger protein that encodes and transduces the origin of synaptic and extrasynaptic NMDA receptor signals to the nucleus. The protein assembles a signalosome that differs in case of synaptic or extrasynaptic NMDAR activation.
Guilherme M. Gomes, Julia Bär, Anna Karpova, Michael R. Kreutz   +3 more
doaj   +1 more source

Short high fat diet triggers reversible and region specific effects in DCX+ hippocampal immature neurons of adolescent male mice

Scientific Reports, 2021
Adolescence represents a crucial period for maturation of brain structures involved in cognition. Early in life unhealthy dietary patterns are associated with inferior cognitive outcomes at later ages; conversely, healthy diet is associated with better ...
Fausto Chiazza, Heather Bondi, Irene Masante, Federico Ugazio, Valeria Bortolotto, Pier Luigi Canonico, Mariagrazia Grilli   +6 more
doaj   +1 more source

An updated suite of viral vectors for in vivo calcium imaging using intracerebral and retro-orbital injections in male mice

Nature Communications, 2023
Genetically encoded Ca2+ indicators (GECIs) are used to measure neural activity. Here, authors screen GECI constructs for suitability with systemic injections and soma-targeting, and modify a soma-targeting peptide for improved expression rate.
Sverre Grødem, Ingeborg Nymoen, Guro Helén Vatne, Frederik Sebastian Rogge, Valgerður Björnsdóttir, Kristian Kinden Lensjø, Marianne Fyhn   +6 more
doaj   +1 more source

Detection of Resting-State Functional Connectivity from High-Density Electroencephalography Data: Impact of Head Modeling Strategies

Brain Sciences, 2021
Recent technological advances have been permitted to use high-density electroencephalography (hdEEG) for the estimation of functional connectivity and the mapping of resting-state networks (RSNs).
Gaia Amaranta Taberna, Jessica Samogin, Marco Marino, Dante Mantini   +3 more
doaj   +1 more source

Context value updating and multidimensional neuronal encoding in the retrosplenial cortex

Nature Communications, 2021
Goal-directed behaviors require the brain to integrate information across many task-related dimensions. Here, the authors use a virtual context discrimination paradigm in mice to demonstrate the capacity for neurons in the retrosplenial cortex to exhibit
Weilun Sun, Ilseob Choi, Stoyan Stoyanov, Oleg Senkov, Evgeni Ponimaskin, York Winter, Janelle M. P. Pakan, Alexander Dityatev   +7 more
doaj   +1 more source

Heparan Sulfates Regulate Axonal Excitability and Context Generalization through Ca²⁺/Calmodulin-Dependent Protein Kinase II

Cells, 2023
Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the axon initial segments in the CA1 region of the hippocampus ex vivo ...
Inseon Song, Tatiana Kuznetsova, David Baidoe-Ansah, Hadi Mirzapourdelavar, Oleg Senkov, Hussam Hayani, Andrey Mironov, Rahul Kaushik, Michael Druzin, Staffan Johansson, Alexander Dityatev   +10 more
doaj   +1 more source

The interaction between endogenous GABA, functional connectivity, and behavioral flexibility is critically altered with advanced age

Communications Biology, 2022
An integrated analysis of GABA concentration, interhemispheric phase-based connectivity behavior and in healthy human participants revealed a task-specific association between GABA concentration and motor-cortical connectivity.
Kirstin-Friederike Heise, Laura Rueda-Delgado, Sima Chalavi, Bradley R. King, Thiago Santos Monteiro, Richard A. E. Edden, Dante Mantini, Stephan P. Swinnen   +7 more
doaj   +1 more source