Results 41 to 50 of about 219 (105)
Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer's disease
Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.Abstract INTRODUCTION Cognitively unimpaired (CU) amyloid beta (Aβ)+ individuals with elevated plasma glial fibrillary acidic protein (GFAP) have an increased risk of Alzheimer's disease (AD)‐related progression. We tested the utility of plasma GFAP for population enrichment CU populations in clinical trials.
Bruna Bellaver +36 more
wiley +1 more source
Ciência Rural, 2014 O bloqueio dos canais para cálcio dependentes de voltagem é uma estratégia importante no tratamento do trauma medular, pois previne o influxo exacerbado do cálcio que participa ativamente em processos neurodegenerativos agudos, resultando em ...
Karen Maciel de Oliveira +4 more
doaj +1 more source
Omics‐derived biological modules reflect metabolic brain changes in Alzheimer's disease
Alzheimer's &Dementia, Volume 20, Issue 10, Page 6709-6721, October 2024.Abstract INTRODUCTION Brain glucose hypometabolism, indexed by the fluorodeoxyglucose positron emission tomography ([18F]FDG‐PET) imaging, is a metabolic signature of Alzheimer's disease (AD). However, the underlying biological pathways involved in these metabolic changes remain elusive.
Guilherme Povala +11 more
wiley +1 more source
Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
doaj +1 more source
Terapia celular no acidente vascular cerebral Cell therapy in strokes
Revista Brasileira de Hematologia e Hemoterapia, 2009 O AVC é o recordista em número de óbitos e a maior causa de incapacidade no Brasil. Apesar das inúmeras pesquisas realizadas ao longo dos últimos anos não há terapias farmacológicas adequadas para este quadro e, neste cenário, as terapias celulares vêm ...
Rosalia Mendez-Otero +3 more
doaj
Acta Cirúrgica Brasileira, 2002 Objective: To demonstrate that mild hypothermia can be a protective element when an ischemic onset occurs in rabbit brains. Methods: A rabbit model of focal ischemia was used to test the protection provided by mild hypothermia regionally produced by ...
Mirto Nelso Prandini +3 more
doaj +1 more source
Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies
Arquivos de Neuro-Psiquiatria, 2023 Hepatic encephalopathy (HE) is a potentially reversible neuropsychiatric syndrome. Often, HE causes cognitive and motor dysfunctions due to an acute or chronic insufficiency of the liver or a shunting between the hepatic portal vein and systemic ...
Rafaela Pinto Coelho Santos +2 more
doaj +1 more source
ACIDENTE VASCULAR CEREBRAL ISQUÊMICO CAUSADO POR RHIZOPUS SPP: UM RELATO DE CASO
Brazilian Journal of Infectious Diseases, 2023 A mucormicose, causada por fungos da ordem Mucorales, pode ser angioinvasiva e se manifestar como eventos vasculares isquêmicos. Relata-se aqui um AVEi hemisférico por Rhizopus spp., em paciente com primodiagnóstico de diabetes mellitus.
Julia Ferreira Mari +4 more
doaj +1 more source
O G-CSF na terapia do acidente vascular cerebral The potential role of G-CSF in stroke
Revista Brasileira de Hematologia e Hemoterapia, 2009 O fator estimulador de colônias granulocitárias (G-CSF) é uma glicoproteína descrita há mais de vinte anos, e é largamente utilizada para tratamento de estados neutropênicos e no transplante de medula óssea. O G-CSF estimula células-tronco hematopoéticas
Angelo L. Maset +5 more
doaj
Arquivos de Neuro-Psiquiatria, 2007 We report the case of a severe head injured 43-year old male patient with a large extradural hematoma, Glasgow Coma Scale 3 and dilated fixed pupils.
Paulo Roberto Louzada +8 more
doaj +1 more source