Results 21 to 30 of about 1,121 (139)

Selective therapeutic hypothermia: A review of invasive and noninvasive techniques

Arquivos de Neuro-Psiquiatria, 2011
OBJECTIVE: Therapeutic hypothermia is a promising treatment to prevent secondary neurologic injury. Clinical utility is limited by systemic complications of global hypothermia. Selective brain cooling remains a largely uninvestigated application.
David Straus, Vinay Prasad, Lorenzo Munoz   +2 more
doaj   +1 more source

Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes

Oxidative Medicine and Cellular Longevity, Volume 2017, Issue 1, 2017., 2017
The impairment of astrocyte functions is associated with diabetes mellitus and other neurodegenerative diseases. Astrocytes have been proposed to be essential cells for neuroprotection against elevated levels of methylglyoxal (MG), a highly reactive aldehyde derived from the glycolytic pathway.
Fernanda Hansen, Fabiana Galland, Franciane Lirio, Daniela Fraga de Souza, Carollina Da Ré, Rafaela Ferreira Pacheco, Adriana Fernanda Vizuete, André Quincozes-Santos, Marina Concli Leite, Carlos-Alberto Gonçalves, Ana Ledo   +10 more
wiley   +1 more source

Selective hypothermia: an experimental study on traumatic brain injury in rats Hipotermia seletiva: estudo experimental de traumatismo crânio-encefálico em ratos

Arquivos de Neuro-Psiquiatria, 2008
OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried ...
Amylcar Edemilson Dvilevicius, Mirto Nelso Prandini   +1 more
doaj   +1 more source

Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
Melatonin is synthesized by several tissues besides the pineal gland, and beyond its regulatory effects in light‐dark cycle, melatonin is a hormone with neuroprotective, anti‐inflammatory, and antioxidant properties. Melatonin acts as a free‐radical scavenger, reducing reactive species and improving mitochondrial homeostasis.
Josiel Mileno Mack, Marissa Giovanna Schamne, Tuane Bazanella Sampaio, Renata Aparecida Nedel Pértile, Pedro Augusto Carlos Magno Fernandes, Regina P. Markus, Rui Daniel Prediger, Serafina Perrone   +7 more
wiley   +1 more source

Síndrome glaucomatosa em cães: parte 2 Glaucomatous syndrome in dogs: part 2

Ciência Rural, 2007
O glaucoma mantém-se como uma das principais causas de cegueira em pacientes humanos e entre os animais domésticos. No curso da sua patogênese, ocorre aumento da pressão intra-ocular e morte de células retinianas, cujo início pode ser precoce.
Alexandre Pinto Ribeiro, Bianca da Costa Martins, José Luiz Laus   +2 more
doaj   +1 more source

Virtual Screening of Acetylcholinesterase Inhibitors Using the Lipinski’s Rule of Five and ZINC Databank

BioMed Research International, Volume 2015, Issue 1, 2015., 2015
Alzheimer’s disease (AD) is a progressive and neurodegenerative pathology that can affect people over 65 years of age. It causes several complications, such as behavioral changes, language deficits, depression, and memory impairments. One of the methods used to treat AD is the increase of acetylcholine (ACh) in the brain by using acetylcholinesterase ...
Pablo Andrei Nogara, Rogério de Aquino Saraiva, Diones Caeran Bueno, Lílian Juliana Lissner, Cristiane Lenz Dalla Corte, Marcos M. Braga, Denis Broock Rosemberg, João Batista Teixeira Rocha, Miroslav Pohanka   +8 more
wiley   +1 more source

ID-10 Efeitos Sexo-Dependentes do Metilfenidato Sobre a Bioenergética Mitocondrial e Espécies Reativas de Oxigênio no Córtex Pré-Frontal de Ratos Jovens

Jornal de Assistência Farmacêutica e Farmacoeconomia
Introdução: O metilfenidato (MFD), também conhecido pelo nome comercial Ritalina®, é uma droga neuroestimulante prescrita para o tratamento do Transtorno de Déficit de Atenção e Hiperatividade (TDAH).
Laura Teixeira da Rosa, Alessandra Schmitt Rieder, Osmar Vieira Ramires Júnior, Gustavo Ricardo Krupp Prauchner, Guilherme Carvalho Serena, Angela Terezinha de Souza Wyse   +5 more
doaj   +1 more source

Antinociceptive Activity and Redox Profile of the Monoterpenes (+)‐Camphene, p‐Cymene, and Geranyl Acetate in Experimental Models

International Scholarly Research Notices, Volume 2013, Issue 1, 2013., 2013
Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)‐camphene, p‐cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)‐camphene, p‐cymene, and geranyl acetate using different free radical‐generating systems and evaluation of antinociceptive
Lucindo Quintans-Júnior, José C. F. Moreira, Matheus A. B. Pasquali, Soheyla M. S. Rabie, André S. Pires, Rafael Schröder, Thallita K. Rabelo, João P. A. Santos, Pollyana S. S. Lima, Sócrates C. H. Cavalcanti, Adriano A. S. Araújo, Jullyana S. S. Quintans, Daniel P. Gelain, T. Bahorun, M. L. Miranda Fernandes Estevinho, E. Vilanova   +15 more
wiley   +1 more source

Medidas de neuroproteção aplicada a prematuridade: Revisão de literatura

, 2022
Escola Bahiana de Medicina e Saúde PúblicaIntrodução: A unidade de terapia intensiva neonatal (UTIN) proporciona um tratamento qualificado e especializado aos recém-nascidos (RN), em especial aos que nascem prematuramente.
AMADO, Bruna Vital, SOUZA, Mayana de Azevedo Bião de   +1 more
core  

Effects of Diphenyl Diselenide on Methylmercury Toxicity in Rats

BioMed Research International, Volume 2013, Issue 1, 2013., 2013
This study investigates the efficacy of diphenyl diselenide [(PhSe)2] in attenuating methylmercury‐ (MeHg‐)induced toxicity in rats. Adult rats were treated with MeHg [5 mg/kg/day, intragastrically (i.g.)] and/ or (PhSe)2 [1 mg/kg/day, intraperitoneally (i.p.)] for 21 days.
Cristiane L. Dalla Corte, Caroline Wagner, Jéssie H. Sudati, Bruna Comparsi, Gerlania O. Leite, Alcindo Busanello, Félix A. A. Soares, Michael Aschner, João B. T. Rocha, Fernando Barbosa Jr.   +9 more
wiley   +1 more source