Uso de um método não invasivo no monitoramento da pressão intracraniana em unidade de terapia intensiva para melhorar a neuroproteção em pacientes no pós-operatório de cirurgia cardíaca após circulação extracorpórea [PDF]
Revista Brasileira de Terapia Intensiva, 2021 RESUMO Desde a instituição da circulação extracorpórea, há cinco décadas, a lesão cerebral decorrente desse procedimento durante cirurgias cardiovasculares tem sido uma complicação frequente.
Salomón Soriano Ordinola Rojas +3 more
doaj +4 more sources
Selective hypothermia: an experimental study on traumatic brain injury in rats Hipotermia seletiva: estudo experimental de traumatismo crânio-encefálico em ratos [PDF]
Arquivos de Neuro-Psiquiatria, 2008 OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried ...
Amylcar Edemilson Dvilevicius +1 more
doaj +3 more sources
Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion. [PDF]
Oxid Med Cell Longev, 2020 Degeneration of the locus coeruleus (LC), the main source of cerebral noradrenaline (NA), has been reported in diverse neurodegenerative diseases, including Parkinson’s diseases (PD). There is increasing evidence indicating the role of NA deficiency in the prefrontal cortex (PFC) and the development of early cognitive impairments in PD.
Sampaio TB +4 more
europepmc +2 more sources
Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder. [PDF]
J NeurochemAlterations in oxytocin signaling are strongly implicated in the social and cognitive deficits characterizing Autism Spectrum Disorder (ASD) and other neurodevelopmental conditions. However, the precise mechanisms remain unclear. The zebrafish (Danio rerio) has emerged as a powerful translational model due to its evolutionarily conserved oxytocin ...
Peres G, Wiprich MT, Gusso D, Bonan CD.
europepmc +2 more sources
Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health. [PDF]
J NeurochemElevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Ramires Júnior OV +5 more
europepmc +2 more sources
P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice [PDF]
Frontiers in Pharmacology, 2023 Introduction: Sepsis is defined as a multifactorial debilitating condition with high risks of death. The intense inflammatory response causes deleterious effects on the brain, a condition called sepsis-associated encephalopathy.
Vinícius Santos Alves +17 more
doaj +2 more sources
ANÁLOGOS DO GLP-1 E NEUROPROTEÇÃO: UMA REVISÃO SISTEMÁTICA [PDF]
Brazilian Journal of Implantology and Health Sciences, 2023 Diabetes Mellitus 2 (DM2) is a chronic disease with growing incidence, resulting in increased morbidity and mortality due to associated complications, including neurodegeneration and structural changes, related to insulin resistance and hyperglycemia ...
Castro, Júlia Vasconcellos +3 more
core +3 more sources
Como Funciona o Xénon: Mecanismos de Neuro e Cardioprotecção [PDF]
Acta Médica Portuguesa, 2014 Introdução: O xénon, um gás nobre, possui qualidades anestésicas, associadas a uma notável estabilidade hemodinâmica assim como propriedades cardioprotectoras e neuroprotectoras.
Ricardo Morais +3 more
doaj +2 more sources
Neuroproteção na ressecção cirúrgica de gliomas cerebrais: revisão da evidência atual [PDF]
Brazilian Journal of Development, 2023 Os gliomas cerebrais são tumores primários do sistema nervoso central que se desenvolvem a partir de células gliais e têm alta morbimortalidade. Seu tratamento padrão envolve a ressecção cirúrgica, radioterapia e quimioterapia, os quais possivelmente ...
Amorim, Marta Gabriela Araújo +34 more
core +3 more sources
Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease [PDF]
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
doaj +2 more sources