Results 11 to 20 of about 1,121 (139)

Role of Prefrontal Cortex on Recognition Memory Deficits in Rats following 6-OHDA-Induced Locus Coeruleus Lesion. [PDF]

Oxid Med Cell Longev, 2020
Degeneration of the locus coeruleus (LC), the main source of cerebral noradrenaline (NA), has been reported in diverse neurodegenerative diseases, including Parkinson’s diseases (PD). There is increasing evidence indicating the role of NA deficiency in the prefrontal cortex (PFC) and the development of early cognitive impairments in PD.
Sampaio TB, Marques NF, Binder LB, Tasca CI, Prediger RD.   +4 more
europepmc   +2 more sources

Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder. [PDF]

J Neurochem
Alterations in oxytocin signaling are strongly implicated in the social and cognitive deficits characterizing Autism Spectrum Disorder (ASD) and other neurodevelopmental conditions. However, the precise mechanisms remain unclear. The zebrafish (Danio rerio) has emerged as a powerful translational model due to its evolutionarily conserved oxytocin ...
Peres G, Wiprich MT, Gusso D, Bonan CD.
europepmc   +2 more sources

A three‐range approach enhances the prognostic utility of CSF biomarkers in Alzheimer's disease

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 8, Issue 1, 2022., 2022
Abstract Introduction Alzheimer's disease consensus recommends biomarker dichotomization, a practice with well‐described clinical strengths and methodological limitations. Although neuroimaging studies have explored alternative biomarker interpretation strategies, a formally defined three‐range approach and its prognostic impact remains under‐explored ...
Wagner S. Brum, Marco Antônio de Bastiani, Andrei Bieger, Joseph Therriault, João P. Ferrari‐Souza, Andréa L. Benedet, Paramita Saha‐Chaudhuri, Diogo O. Souza, Nicholas J. Ashton, Henrik Zetterberg, Tharick A. Pascoal, Thomas Karikari, Kaj Blennow, Pedro Rosa‐Neto, Eduardo R. Zimmer, Alzheimer's Disease Neuroimaging Initiative (ADNI)   +15 more
wiley   +1 more source

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health. [PDF]

J Neurochem
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Ramires Júnior OV, Prauchner GRK, Rieder AS, Leite AKO, Farias CP, Wyse ATS.   +5 more
europepmc   +2 more sources

Impactos da ministração de sulfato de magnésio como estratégia de neuroproteção em fetos prematuros [PDF]

, 2022
   A formação neuronal é uma das fases mais críticas do desenvolvimento fe-tal, já que qualquer intercorrência que comprometa esse processo pode trazer im-portantes sequelas para o recém-nascido.
Moraes, Alexandre Vieira Santos, Bernardes, Gabriel Rezende Megale, de Oliveira, Luis Miguel Fonseca, Moraes, Vitor Ryuiti Yamamoto, Negreiros, João Victor Beraldo, Rizzo, Esther Piretti Marques   +5 more
core   +1 more source

Neuroproteção na ressecção cirúrgica de gliomas cerebrais: revisão da evidência atual [PDF]

, 2023
Os gliomas cerebrais são tumores primários do sistema nervoso central que se desenvolvem a partir de células gliais e têm alta morbimortalidade. Seu tratamento padrão envolve a ressecção cirúrgica, radioterapia e quimioterapia, os quais possivelmente ...
Lima, Larissa do Nascimento Fernandes, Rodrigues, Daniel Vitor dos Santos, Cavalcante, Lucas Sousa, Xavier, Larissa Marques Barbosa, Amorim, Marta Gabriela Araújo, Moraes Neta, Antonina Linhares, da Cruz, Cynara Tábata Lisbino, Costa, Enzo Matheus Morais, Lima, Francisco Jose da Conceicao, Gomes, Vitória Alvina Ferreira Lima, de Moraes Neta, Maria do Rosário, Dall’agnol, Mauricio Luis, Mendes Neto, Pedro Cunha, Vasconcelos, Letícia Arruda, Ver-Vallen, Victoria Martins Vasquez, Costa, Guilherme Albuquerque de Araujo, Veras, Katiane Gomes de Melo, Macedo Filho, Fábio Henrique Dias, de Matos, Lara Bezerra, Maranhão, Tatiana Carenina Farias, Monteiro, Julyanna Assunção Silva, de Araújo, Michelle Rahbani Martins, Menezes, Lucas de Oliveira, Gomes, Raylane de Souza Silva, Schmitt, Igor Murad, do Vale, Tereza Cristina Barbosa Ribeiro, Rodrigues Junior, Josimar Cunha, Frazão, Júlio Cézar Martins, Catarino, Patrícia Carla Guimarães, Ribeiro, Evelyn Conceição Fonseca, Schiattarella Filho, Giuseppe de Souza, Cavalcante, Emanuela Vitória de Barros Tavares, Braga Filho, Marcone Douglas, Lazera, Victória de Menezes Sá, Neres, Barbara Cristina Rodrigues   +34 more
core   +1 more source

ANÁLOGOS DO GLP-1 E NEUROPROTEÇÃO: UMA REVISÃO SISTEMÁTICA [PDF]

, 2023
Diabetes Mellitus 2 (DM2) is a chronic disease with growing incidence, resulting in increased morbidity and mortality due to associated complications, including neurodegeneration and structural changes, related to insulin resistance and hyperglycemia ...
Júlia Vasconcellos Castro, Cruz, Thainá Baltazar Ferreira da, Tostes, Glauce Cordeio Ulhôa, Thainá Baltazar Ferreira da Cruz, Isabela Oliveira Fonseca, Glauce Cordeio Ulhôa Tostes, Castro, Júlia Vasconcellos, Fonseca, Isabela Oliveira   +7 more
core   +1 more source

Mecanismos de Neuroproteção por Produtos Naturais. Prevenção ou Terapia?

, 2016
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014As plantas alimentares (frutas e legumes) sintetizam uma vasta gama de compostos químicos, sendo que alguns destes apresentam propriedades ...
Cerdeira, Leocádia Neto
core   +3 more sources

Pre, intra and post-ischemic hypothermic neuroprotection in temporary focal cerebral ischemia in rats: morphometric analysis

Arquivos de Neuro-Psiquiatria, 2012
OBJECTIVE: To evaluate the neuroprotection of mild hypothermia, applied in different moments, in temporary focal cerebral ischemia in rats. METHODS: Rats was divided into Control (C), Sham (S), Ischemic-control(IC), Pre-ischemic Hypothermia (IH1), Intra ...
Roberto Alexandre Dezena, Benedicto Oscar Colli, Carlos Gilberto Carlotti Junior, Luís Fernando Tirapelli   +3 more
doaj   +1 more source

Neuroprotective effect of mild hypothermia in the temporary brain ischemia in cats Efeito neuroprotetor da hipotermia leve na isquemia cerebral focal temporária em gatos

Arquivos de Neuro-Psiquiatria, 2007
OBJECTIVE: To evaluate the neuroprotective effect of mild hypothermia during temporary focal ischemia in cats. METHOD: 20 cats underwent middle cerebral artery 60 minutes occlusion and 24 hours reperfusion: 10 under normothermia and 10 under mild ...
Hiroshi Nakano, Benedicto Oscar Colli, Luiza da Silva Lopes   +2 more
doaj   +1 more source