Results 131 to 140 of about 184,954 (326)

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

Annals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante, Francesca Pischiutta, Elena Restelli, Federico Moro, Maria Antonietta Chiaravalloti, Ilaria Raimondi, Ilaria Bertani, Ilaria Lisi, Eliana Sammali, Rosaria Pascente, Serena Scozzari, Laura Pasetto, Carly Douglas, Marco Locatelli, Fabrizio Ortolano, Valentina Bonetto, David J. Loane, Nino Stocchetti, Roberto Chiesa, Elisa R. Zanier   +19 more
wiley   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Valorization of the peel and husk of guaraná (Paullinia cupana): oil extraction, chemical composition, cytotoxicity, and antitumor potential

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract Guaraná (Paullinia cupana) is a fruit native to the Amazon region. Due to its widespread use, primarily in beverages, its production has grown over the years. The seed is the only commercially valuable part of the fruit so the guaraná production chain generates byproducts, including peel, husk, and spent seed.
Leiliane do Socorro Sodré de Souza, Guilherme Teixeira de Azevedo, Eduardo Leonarski, Giovana Lima de Souza, Rafael Lopes e Oliveira, Sérgio Duvoisin Junior, Karina Cesca, Débora de Oliveira, Anderson Mathias Pereira, Ariane Mendonça Kluczkovski   +9 more
wiley   +1 more source

Improved neuroprotection using miglustat, curcumin and ibuprofen as a triple combination therapy in Niemann–Pick disease type C1 mice

, 2014
Ian M. Williams, Kerri‐Lee Wallom, David A. Smith, Nada Al Eisa, Claire Smith, Frances M. Platt   +5 more
openalex   +2 more sources

Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of silk fibroin‐based biomaterials in spinal cord injury repair, focusing on environmentally friendly processing techniques, and the strategies for designing composite scaffolds as well as discussing the advantages and current challenges of silk fibroin‐based biomaterials in spinal ...
Xiaoliang Cui, Xuanwen Wang, Siying Liu, Lilei Wang, Menghong Li, Jun Zhang, Li Wang, Ke‐Qin Zhang   +7 more
wiley   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection
Neuroinflammation, a key defense mechanism of the nervous system, is associated with changes in inflammatory markers and stimulation of neuroimmune cells such as microglia and astrocytes.
Lingjie Mu, Yijie Wang
doaj   +1 more source

The Potential Effects of Phytoestrogens: The Role in Neuroprotection [PDF]

, 2021
Justyna Gorzkiewicz, Grzegorz Bartosz, Izabela Sadowska‐Bartosz   +2 more
openalex   +1 more source

Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats [PDF]

, 2003
Recent experimental evidences indicate that pyruvate, the final metabolite of glycolysis, has a remarkable protective effect against different types of brain injury.
Candelario-Jalil, Eduardo, Garcia-Cabrera, Michel, Gonzalez-Falcon, Armando, Leon, Olga S.   +3 more
core  

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source