Results 141 to 150 of about 177,883 (410)

Oxygen sensors and energy sensors act synergistically to achieve a graded alteration in gene expression: consequences for assessing the level of neuroprotection in response to stressors [PDF]

, 2004
M.C. Renshaw Gillian
openalex   +1 more source

Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner

Journal of Neuroinflammation, 2019
Oxidative stress and neuroinflammation are considered the major central events in the process of Parkinson’s disease (PD). Nrf2 is a key regulator of endogenous defense systems. New finds have contacted activation of Nrf2 signaling with anti-inflammatory
Bei Zhang, Guoqing Wang, Jingyi He, Qiuyu Yang, Dai‐di Li, Jing-jie Li, Feng Zhang   +6 more
semanticscholar   +1 more source

Interaction of FXTAS Family History and College Degree Attainment Predicts Trajectories of Cognitive and Motor Symptoms in FMR1 Premutation Carrier Women

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT The present longitudinal study focuses on FMR1 premutation carrier women during midlife and early old age (n = 115). Bringing together the genetic risk factor of a family history of FXTAS and the environmental protective factor of higher education, the goal of the study was to determine how these factors potentially interact to predict self ...
Jinkuk Hong, Leann Smith DaWalt, Jessica Klusek, Elizabeth M. Berry‐Kravis, Marsha Mailick   +4 more
wiley   +1 more source

The effects and mechanisms of stem cells and exosomes on neurological function protection and recovery after ischemic stroke

Neuroprotection
Stroke can cause motor sensory impairment and cognitive impairment. Current interventions focus on thrombolysis or thrombectomy in the acute stage, and promoting the recovery of neurological function during the chronic stage.
Weihong Du, Yuxian He, Liangchen Li, Xinchun Jin, Panpan Geng   +4 more
doaj   +1 more source

Frog-derived peptides and neuroprotection

The incidence of age-related diseases (e.g., neurodegenerative diseases) is increasing as the world’s population lives longer. Neurodegeneration, the dysfunction and loss of neurons, is a hallmark of chronic (e.g., Alzheimer’s disease and Parkinson’s ...
Moreira, Daniel C., Batagin-Neto, Augusto [UNESP], Leite, José Roberto S.A.   +2 more
core   +1 more source

New possibilities of neuroprotection in ischemic stroke

, 2011
Reperfusion and neuroprotection are two present-day therapy strategies for patients with acute stroke. The paper reviews currently available drugs used for neuroprotection in ischemic strokes in the context of evidence-based ...
D. V. Sergeyev, F. R. Okhtova, A. N. Sergeyeva, M. A. Domashenko, M. Yu. Maksimova, M. A. Piradov   +5 more
core   +1 more source

Centella asiatica – Phytochemistry and mechanisms of neuroprotection and cognitive enhancement

Phytochemistry Reviews, 2017
This review describes in detail the phytochemistry and neurological effects of the medicinal herb Centella asiatica (L.) Urban. C. asiatica is a small perennial plant that grows in moist, tropical and sub-tropical regions throughout the world ...
Nora E. Gray, Armando Alcázar Magaña, P. Lak, K. Wright, J. Quinn, J. F. Stevens, C. Maier, A. Soumyanath   +7 more
semanticscholar   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Therapeutic potential of stem cells in pediatric neurology: Insights from clinical trials

Neuroprotection
Pediatric neurological disorders comprise diverse conditions that impair nervous system function in children and contribute substantially to global disease burden.
Daniel Bou Najm, Saada Alame
doaj   +1 more source

VIP-induced neuroprotection of the developing brain.

, 2011
International audienceExcitotoxicity is a key molecular mechanism of perinatal brain damage and is associated with cerebral palsy and long term cognitive deficits.
Sandrine Passemard, Pierre Gressens, Sokolowska, Paulina, Paulina Sokolowska, Passemard, Sandrine, Gressens, Pierre, Leslie Schwendimann, Schwendimann, Leslie   +7 more
core   +1 more source