Results 131 to 140 of about 132,339 (311)

MN•CS•IO System: Cross‐Species Study for HBB Function in High‐Altitude Hypoxia Adaptation

Advanced Science, EarlyView.
We developed an integrative mesh‐nanorod sorting, chitosan nanoparticle delivery, and intraosseous injection (MN•CS•IO) system to investigate HBB in high‐altitude hypoxia adaptation. Transplanting Tibetan animals' HBB‐modified Lin‐ cells into mice achieved 95.59% transfection efficiency and 8.15% HBB expression. High‐altitude HBB recipients upregulated
Wenqiao Hui, Lin Mao, Binggang Li, Hanyue Kang, Zhengquan Tang, Sheng Chen, Hui Yang, Yu Qiao, Huiqian Ding, Yuhuan Wang, Min Li, Junjie Hu, Shoudong Ye, Xin Wang, Xiaobin Xu, Yupeng Wang, Tana Wuren, Qian Ban, Baowei Zhang   +18 more
wiley   +1 more source

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

Neuroprotection
Recent advances in neuroscience have illuminated the central role of glutamate dysregulation in various neurological disorders. The glutamatergic system has emerged as a central player in the pathophysiology of various neurological disorders.
Jorge Y. Magdaleno Roman, Christian Chapa González   +1 more
doaj   +1 more source

New strategies in neuroprotection and neurorepair

, 2012
There are currently few clinical strategies in place, which provide effective neuroprotection and repair, despite an intense international effort over the past decades.
Guillemin, GJ (15525581), Aschner, M (15507638), Collins, MA (15556220), Moratalla, R (15556226), Del-Bel, EA (15556217), Tizabi, Y (15556223), Antonelli, MC (15556211), Raisman-Vozari, R (15556214), Adrian West (14752555)   +8 more
core  

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source

Impact of neutrophil‐to‐lymphocyte ratio on the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy

Neuroprotection
Background The neutrophil‐to‐lymphocyte ratio (NLR) is highly associated with stress responses to acute disorders and may be useful for differentiating hyperglycemia after stroke that is induced by stress or other causes.
Tao Tang, Dawei Zhang, Fang Wang, Tieping Fan, Aline M. Thomas, Xiaoyan Lan, Manhong Zhao, Di Li, Xinghui Zhao   +8 more
doaj   +1 more source

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

Interleukin‐6 induces cognitive impairment via toll‐like receptor 4 (TLR4)‐mediated neuroinflammation and neurodegeneration in mice with chronic kidney disease

Neuroprotection
Backgrounds Past epidemiological and experimental studies in rodents have demonstrated that chronic kidney disease (CKD) leads to cognitive impairment. However, the underlying mechanism requires further investigation.
Yangping Shentu, Shuqing Ma, Simin Ye, Yaozhe Ying, Luhui Wang, Yun Zhu, YunTing Wang, Nan Jiang, Zongyuan Zhao, Chenfei Zheng, Chaosheng Chen, Yongheng Bai, Ying Zhou   +12 more
doaj   +1 more source

Neuroprotection Benedetto Falsini, Ronald A. Bush, Paul A. Sieving

, 2013
The process of neuronal cell death following different types of injury involves apoptosis. Blocking the apoptotic cascade leading to cell death may prevent cell death and consequent loss follow- ing neuronal injury (neuroprotection).
Falsini, Benedetto
core  

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Liver enzyme and risk of vascular dementia: A univariable and multivariable Mendelian randomization of European descent

Neuroprotection
Background Observational studies have indicated a link between liver enzymes and dementia, but the causal relationship remains uncertain. We conducted a two‐sample Mendelian randomization (MR) study to investigate potential causal links between liver ...
Jieyu Chen, Jianzhun Chen, Chunyu Liang, Chenxi Liu, Liu Jie, Bin Liu, Xinglong Yang   +6 more
doaj   +1 more source