Results 151 to 160 of about 132,339 (311)

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection
Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear ...
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
doaj   +1 more source

Lithium and neuroprotection

, 2005
Neuroprotection can be defined as medical prophylactic and therapeutic intervention aimed at neuronal tissue and function. Hardly any concept of neuroprotection has been convincingly efficient in man thus far. Lithium has been used for the treatment of
Nordeng, Jostein
core  

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection
Adaptive plasticity, the brain's ability to reorganize and form new neural connections after injury, is crucial for recovery following acquired brain injury (ABI).
Ravi Kumar Rajan
doaj   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Environmental enrichment modulates chronic poststroke inflammation and links white matter TREM2‐positive microglia in recovery in mice

Neuroprotection
Background Environmental enrichment (EE) has been widely reported to improve functional recovery after stroke, yet its effects on chronic inflammation and white matter pathology remain less well defined.
Lluís Camprubí‐Ferrer, Ömer K. Kolbay, Miriana J. Quattromani, Tadeusz Wieloch, Karsten Ruscher, Tomas Deierborg   +5 more
doaj   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Rehabilitation paired with vagus nerve stimulation for motor function of chronic ischemic stroke patients in China: Study protocol of a multicenter randomized controlled trial (Repair Study)

Neuroprotection
Background Stroke remains the leading cause of long‐term disability worldwide. Approximately 60% of individuals with chronic ischemic stroke experience persistent upper limb impairment that limits daily activities.
Anchao Yang, Yong Liu, Hongxing Huang, Xiaoqin Sun, Dawei Zang, Jun Lu, Qingping Tang, Yulian Zhu, Qi Yue, Weining Wang, Guohui Lu, Lang Shuai, Jun Wang, Yunqian Li, Li Bie, Zhenlan Li, Guoxing Xu, Jinghui Li, Tao Ding, Yanwu Guo, Wen Wu, Yuting Xu, Yuanxiang Lin, Zhiyong Wang, Fuxin Lin, Chunhua Hang, Rong Xu, Xiangyu Liu, Wenjun Hong, Kai Shu, Min Lu, Feng Hu, Ruobing Qian, Ming Wu, Liuzhong Sun, Min Wu, Yingchuan Chen, Qian Wang, Sihao Liu, Qiao Zhang, Shiyi Zuo, Binxia Zhang, Wei Wu, Zhongming Wang, Huayang Deng, Lijuan Quan, Renli Qi, Wei Wang, Fuchuan Huang, Xiemin Liang, Feng Wang, Yalan Wang, Zejian Chen, Jiang Ran, Liang Chen, Jianguo Zhang, Ying Mao   +56 more
doaj   +1 more source

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

Advanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan, Haoming Shu, Rui Gao, Yilong Ren, Wu Ye, Xuhui Ge, Yao Gu, Yufeng Zhu, Xiaokun Wang, Honglin Teng, Xuhui Zhou, Wei Liu, Yang Gao, Jianquan Zhao, Weihua Cai   +14 more
wiley   +1 more source

Post‐Omicron cognitive decline is largely reversible: Two‐year multicenter cohort study of domain‐specific outcomes in hospitalized patients

Neuroprotection
Background Cognitive impairment represents a significant concern within the spectrum of post‐acute sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) infection, particularly impacting the aging population. This study aimed to assess
Min Qiu, Mengwen Wang, Shengcai Chen, Wenbo Zuo, Jiashuo Lin, Luojinyun Wang, Senwei Tan, Quanwei He, Yanan Li, Huijuan Jin, Xuan Niu, Wanli Li, Fengguang Li, Ming Huang, Yan Wan, Bo Hu   +15 more
doaj   +1 more source