Results 171 to 180 of about 177,883 (410)

Effects of senescence on astrocyte to brain endothelial cell signaling

Neuroprotection
Background Aging affects almost all aspects of central nervous system (CNS) function, including the blood–brain barrier (BBB). Here, we use cell culture models to ask whether senescence, a cellular feature of aging, alters the BBB by modifying ...
Shuzhen Guo, Gen Hamanaka, Fang Zhang, Janice Lee, Ji Hyun Park, Wenlu Li, Ken Arai, Eng H. Lo   +7 more
doaj   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Neuroprotection and repair

Journal of the Neurological Sciences, 2008
Neuroprotection can be applied to treatments that have a primary role in protecting nerves and axons from damage. Alternatively it can refer to treatments which act up-stream on the primary pathology and which have a secondary neuroprotective effect. Although there are many potential neuroprotective agents, clinical evidence to prove their hypothetical
openaire   +3 more sources

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Phenytoin for neuroprotection [PDF]

The Lancet Neurology, 2016
Elena H, Martinez-Lapiscina, Magi, Andorra, Bernardo, Sanchez-Dalmau, Pablo, Villoslada   +3 more
openaire   +5 more sources

Molecularly Engineered Dual‐Crosslinked Polymer Dielectrics for 200 °C Capacitive Energy Storage

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work establishes a molecular engineering strategy that constructs a robust dual‐crosslinked network in polymer nanocomposites, achieving a record‐high energy density of 5.17 J cm−3 with >90% efficiency at 200 °C. The multiscale‐validated design simultaneously enhances dielectric polarization and introduces deep electron traps, resulting in ...
Xue Li, Ling Weng, Lizhu Guan, Xiaoming Wang, Ze Li, Xiaorui Zhang, Ruiqun Pan, Yuhan Li, Zijian Wu, Yingtang Zhang   +9 more
wiley   +1 more source

A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs

BioTech
The adult lumbar spinal cord plays a critical role in locomotor control and somatosensory integration, whose transcriptional architecture under physiological conditions has been characterized in various studies with restricted numbers of individuals (up ...
Pablo Ruiz-Amezcua, Miguel Nieto Hernández, Javier García Flores, Clara Plaza Alonso, David Reigada, Teresa Muñoz-Galdeano, Eva Vargas, Rodrigo M. Maza, Francisco J. Esteban, Manuel Nieto-Díaz   +9 more
doaj   +1 more source

Bioenergetic-based neuroprotection and glaucoma

, 2008
Website © 2008 Ingenta. Article copyright remains with the publisher, society or author(s) as specified within the articlePrimary open-angle glaucoma (POAG) is a pressure-sensitive optic neuropathy which results in the death of retinal ganglion cells and
Chidlow, G., Casson, R., Wood, J., Schober, M.   +3 more
core   +1 more source

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

Epilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin, Hui‐Min Huang, Hui‐An Lin, Sheng‐Feng Lin   +3 more
wiley   +1 more source

Neuroprotection in Glaucoma: A Review

, 2013
Background: Glaucoma, globally the second most common cause of blindness and the commonest cause of preventable visual disability, is a progressive neurodegenerative disease of the retinal ganglion cells and their axons .Neuroprotection is an evolving ...
Awoyesuku, EA, Fiebai, B
core