Results 181 to 190 of about 118,682 (313)

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Nanotechnology for ischemic stroke treatment: addressing challenges across stroke management stages. [PDF]

Front Mol Biosci
Wu Y, Wang L, Zou C, Meng X, Yang P, Zhang H.   +5 more
europepmc   +1 more source

Tannic Acid Mitigates Monosodium Glutamate‐Induced Cortical Damage by Modulating Synaptic and Calcium‐Related Gene and Protein Expression

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neurotoxicity induced by excessive glutamatergic signaling is associated with synaptic dysfunction, calcium imbalance, and oxidative stress, which are key molecular events implicated in several neurodegenerative conditions. Monosodium glutamate (MSG), a common flavor enhancer, may exert neurotoxic effects, particularly on synaptic integrity ...
Medine Sibel Karagac, Enver Fehim Koçpinar, Hamid Ceylan   +2 more
wiley   +1 more source

Corrigendum to "Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons" [Mol. Cell. Endocrinol. 384 1-2 (2014) 52-60]. [PDF]

Mol Cell Endocrinol
Jayaraman A, Pike CJ.
europepmc   +1 more source

Importance in Neuroprotection [PDF]

Deutsches Ärzteblatt international, 2017
openaire   +2 more sources

Biological Effects of Selenium‐Containing Ionic Liquids: Cytotoxicity, Mercury Interaction, and Antiproliferative Activity in Glioblastoma Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Selenium (Se) is an essential micronutrient that participates in redox regulation and cellular homeostasis. Selenium‐containing ionic liquids (ILsSe) have emerged as hybrid compounds combining the properties of organoselenium molecules with the tunable features of ionic liquids.
Guilherme Schmitt Rieder, Alessandro de Souza Prestes, Fernanda D'Avila da Silva, Nilda de Vargas Barbosa, Alix Y. Bastidas Ángel, Mariana F. Soares, Carolina Martins Fernandes, Maria Anttônia Oliveira Petersen, Manuela Moura Silva, Juliete Nathali Scholl, Fabrício Figueiró, Pablo Andrei Nogara, Laura Orian, Eduardo E. Alberto, Michael Ascnher, Diogo Onofre Gomes de Souza, Debora Guerini de Souza, João Batista Teixeira da Rocha   +17 more
wiley   +1 more source

Warm Versus Cold Irrigation in Brain Surgery: A Comprehensive Review. [PDF]

Cureus
Shay A, Johnston HK, Patel AG, Reier L, Arshad M, Siddiqi J.   +5 more
europepmc   +1 more source

Functional Imaging for Identification of Functionally Critical Brain Regions to Spare in Glioma Radiation Therapy Planning: A Systematic Review

Journal of Medical Radiation Sciences, EarlyView.
This review highlights the role of functional imaging in sparing cognitive brain regions during glioma radiotherapy. It shows promising dose reduction without compromising target coverage, but evidence remains limited, requiring standardisation and prospective validation.
Li Wen Yeo, John T. Ryan
wiley   +1 more source

Antenatal magnesium sulphate for preterm foetal neuroprotection in low- and middle-income countries: a scoping review of research studies and guidelines. [PDF]

J Glob Health
Goldsmith S, Karim T, McIntyre S, Rumbold A, Malhotra A, Khandaker G, Arya S, Shepherd E.   +7 more
europepmc   +1 more source