Results 141 to 150 of about 174,618 (333)

Indefatigable CA1 Sector Neuroprotection with Mild Hypothermia Induced 6 Hours after Severe Forebrain Ischemia in Rats [PDF]

, 1999
Frederick Colbourne, Hui Li, Alastair M. Buchan   +2 more
openalex   +1 more source

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Annals of Neurology, EarlyView.
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau, Agnès Sommet, Pierre Payoux, Pierre Gantet, Amel Drif, Hélène Catalá, Claire Thalamas, Christine Tranchant, Franck Durif, Ana Marques, Alexandre Eusebio, Luc Defebvre, Jean‐Christophe Corvol, Stéphane Thobois, Anthime Flaus, Anne‐Gaelle Corbille, Solène Frismand, Beverley Patterson, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Germain Arribarat, Patrice Péran, Olivier Rascol, for the ASPIRE Study Group   +26 more
wiley   +1 more source

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection

Neuroprotection
Recent advances in neuroscience have illuminated the central role of glutamate dysregulation in various neurological disorders. The glutamatergic system has emerged as a central player in the pathophysiology of various neurological disorders.
Jorge Y. Magdaleno Roman, Christian Chapa González   +1 more
doaj   +1 more source

Neuroprotection: role of the antiglaucomatous treatment [PDF]

, 1999
M Virno, Luigi Pannarale
openalex   +1 more source

Intranasal Wharton's Jelly‐Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic‐Ischemic Brain Injury in Mice

Annals of Neurology, EarlyView.
This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije, Sara T. De Palma, Josine E. G. Vaes, Katiuscia Dallaglio, Giorgia Volpi, Diego Ardigò, Sabine van Rijt, Frank van Bel, Manon J. N. L. Benders, Cora H. A. Nijboer   +9 more
wiley   +1 more source

Impact of neutrophil‐to‐lymphocyte ratio on the effect of hyperglycemia at admission on clinical outcomes after endovascular thrombectomy

Neuroprotection
Background The neutrophil‐to‐lymphocyte ratio (NLR) is highly associated with stress responses to acute disorders and may be useful for differentiating hyperglycemia after stroke that is induced by stress or other causes.
Tao Tang, Dawei Zhang, Fang Wang, Tieping Fan, Aline M. Thomas, Xiaoyan Lan, Manhong Zhao, Di Li, Xinghui Zhao   +8 more
doaj   +1 more source

Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons [PDF]

, 2000
Kazuhiro Honda, Hideyuki Sawada, T Kihara, Makoto Urushitani, Tomoki Nakamizo, Akinori Akaike, Shun Shimohama   +6 more
openalex   +1 more source

Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy

Advanced NanoBiomed Research, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali, Rocco Latorre, Raquel Tonello, David Poolman, Suwan Ding, Brian L. Schmidt, Nigel W. Bunnett, Kam W. Leong   +7 more
wiley   +1 more source

Interleukin‐6 induces cognitive impairment via toll‐like receptor 4 (TLR4)‐mediated neuroinflammation and neurodegeneration in mice with chronic kidney disease

Neuroprotection
Backgrounds Past epidemiological and experimental studies in rodents have demonstrated that chronic kidney disease (CKD) leads to cognitive impairment. However, the underlying mechanism requires further investigation.
Yangping Shentu, Shuqing Ma, Simin Ye, Yaozhe Ying, Luhui Wang, Yun Zhu, YunTing Wang, Nan Jiang, Zongyuan Zhao, Chenfei Zheng, Chaosheng Chen, Yongheng Bai, Ying Zhou   +12 more
doaj   +1 more source

Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]

, 2015
Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core