Plant Biotechnology Journal, Volume 21, Issue 1, Page 14-16, January 2023., 2023 PoDPBT, an O‐benzoyltransferase belonging to the BAHD family, can catalyze the benzoylation of 8‐debenzoylpaeoniflorin to paeoniflorin. PoDPBT is the first enzyme demonstrated to be involved in the modification stage of paeoniflorin biosynthesis. DFGGG, a new DFGWG‐like motif, was revealed in the BAHD family.
Xiao‐Xiao Zhang +7 more
wiley +1 more source
Minocycline Provides Neuroprotection AgainstN-Methyl-
, 2001 Tiina Tikka, Jari Koıstınaho
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Semaglutide to remodel mitochondrial dynamics and mitophagy balance for vascular dementia therapy
VIEW, EarlyView.The effects of semaglutide on IR, mitochondrial dynamics, and mitophagy in the hippocampus of BCAS mice after CCH. It was shown that semaglutide maintained the balance of mitochondrial dynamics and mitophagy by improving IR and passing through GLP‐1R/PI3K/Akt pathway, reduced hippocampal neuroinflammation and neuron loss, and thus promoted the recovery
Xiaoyan Yang +11 more
wiley +1 more source
International Journal of Pharmacy Practice, EarlyView., 2020 Abstract Objectives Evidence‐based guidelines have the potential to reduce variation and increase prescribing quality. Identifying the key determinants to their uptake, using a theory‐based approach, may assist in the design of successful interventions to increase their adoption into practice.
Paulina Paksaite +4 more
wiley +1 more source
AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice
Traffic, Volume 24, Issue 1, Page 20-33, January 2023., 2023 Fission events at endo‐lyso interface could be favored in the presence of AP2S1, which is reminiscent of membrane fission during endocytosis. In contrast, lack of AP2S1 may inhibit this process, and alternatively facilitate endo‐lyso fusion and content exchange, leading to lysosomal degradation of APP.
Qi‐Xin Wen +11 more
wiley +1 more source
Neuroprotection by Caffeine and A2AAdenosine Receptor Inactivation in a Model of Parkinson's Disease [PDF]
, 2001 Jiang‐Fan Chen +9 more
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Astrocytic Hevin/SPARCL‐1 Regulates Cognitive Decline in Pathological and Normal Brain Aging
Aging Cell, EarlyView.Hevin/Sparcl‐1 is a synaptogenic protein secreted by astrocytes. We used adeno‐associated virus (AAV) to increase its expression in hippocampal astrocytes of APP/PSEN1 mice, an animal model for Alzheimer's disease (AD). This procedure improved cognitive performance both in the AD model and in middle‐aged wild‐type animals.
Felipe Cabral‐Miranda +3 more
wiley +1 more source
Erythropoietin Receptor-mediated Inhibition of Exocytotic Glutamate Release Confers Neuroprotection during Chemical Ischemia [PDF]
, 2001 Masakatsu Kawakami +4 more
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Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.ABSTRACT We assessed the use of magnesium sulphate prior to preterm birth for preventing cerebral palsy in an Australian and New Zealand registry study. Use increased markedly from 32.3% (2012) to 78.8% (2020) (p < 0.001). Binational approaches to sustain and explore the feasibility of further increasing use, informed by evolving evidence and ...
Emily Shepherd +12 more
wiley +1 more source
Neuroprotection Mediated by Glial Cell Line-Derived Neurotrophic Factor: Involvement of a Reduction of NMDA-Induced Calcium Influx by the Mitogen-Activated Protein Kinase Pathway [PDF]
, 2001 Olivier Nicole +6 more
openalex +1 more source