Results 211 to 220 of about 20,490 (222)

Neuroprotection by Intrathecal Application of Liposome-entrapped Fasudil in a Rat Model of Ischemia.

, 2001
Yoshihiro Takanashi, Tatsuhiro Ishida, Marc Kirchmeier, Ashfaq Shuaib, Theresa M. Allen   +4 more
openalex   +2 more sources

Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction To investigate the predictive value of the biliverdin reductase‐A (BVR‐A) and the homeostasis model assessment for insulin resistance (HOMA‐IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, and to establish a nomogram model.
Li Shen, Xiaole Wei, Nan Wang, Haorui Lv, Jing Huang, Xiaoyan Zhou, Aifang Cheng, Changjiang Ying   +7 more
wiley   +1 more source

Senegenin regulates the mechanism of insomnia through the Keap1/Nrf2/PINK1/Parkin pathway mediated by GAD67

Journal of Sleep Research, EarlyView.
Summary GAD67 impacts insomnia as a key enzyme catalysing the conversion of glutamate (Glu) to gamma‐aminobutyric acid (GABA). Senegenin enhances neuroprotection and is used widely to treat insomnia and other neurological diseases. This study aimed to investigate how senegenin regulates insomnia through a GAD67‐mediated signalling pathway.
Honglin Jia, Xu Chen, Zhengting Liang, Ruining Liang, Jinhong Wu, Yanling Hu, Wenjun Cui, Xingping Zhang   +7 more
wiley   +1 more source

Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction

Neurogastroenterology &Motility, EarlyView.
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley   +1 more source

Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.

, 2001
Jiang‐Fan Chen, Kui Xu, Jacobus P. Petzer, Roland G. W. Staal, Yuehang Xu, Mark A. Beilstein, Patricia K. Sonsalla, Kay Castagnoli, Neal Castagnoli, Michael A. Schwarzschild   +9 more
openalex  

Exercise promotes cognition and hippocampal mitochondrial complex II expression in female rats

Experimental Physiology, EarlyView.
ABSTRACT Evidence supports that exercise defends against age‐associated declines in brain health and protects against neurodegenerative disease. To help understand the molecular basis for the neuroprotection, we examined the impact of training on mitochondrial protein expression within the exercise–brain axis.
Zachary J. White, Keshari H. Sudasinghe, David C. Poole, Stephanie E. Hall   +3 more
wiley   +1 more source

ESM‐1 and GBP‐1 are associated with endothelial dysfunction: emerging biomarkers or key players in the pathophysiology of preeclampsia?

The Journal of Physiology, EarlyView.
Abstract figure legend Endothelial specific molecule‐1 (ESM‐1) and guanylate binding protein‐1 (GBP‐1) are proteins that are produced by activated/dysfunctional endothelial cells and are increased and decreased, respectively, during preeclampsia. It remains to be established whether ESM‐1 and GBP‐1 could potentially be included as biomarkers for the ...
Ines Pronk, Joost H. N. Schuitemaker, Marijke M. Faas, Alexandra M. Smink   +3 more
wiley   +1 more source

HR‐MS Analysis of the Covalent Binding of Edaravone to 5‐Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5‐Formylcytidine Residue

Rapid Communications in Mass Spectrometry, Volume 39, Issue 14, 30 July 2025.
ABSTRACT Rationale Edaravone (EDA) is a radical scavenger and an antioxidant drug approved to treat amyotrophic lateral sclerosis and used as a research tool to explore treatment of neurodegenerative diseases and cancers. It is also a reactive agent, known as PMP (1‐phenyl‐3‐methyl‐5‐pyrazolone), used for the analysis of polysaccharides composition ...
Romain Regnault, Mostafa Kouach, Laurence Goossens, Xavier Thuru, Christian Bailly, Jean‐François Goossens   +5 more
wiley   +1 more source

Ibudilast Protects Retinal Bipolar Cells From Excitotoxic Retinal Damage and Activates the mTOR Pathway

Glia, Volume 73, Issue 5, Page 905-927, May 2025.
Main Points Ibudilast, a MIF and PDE inhibitor, preserves the form and function of the retina, especially bipolar cells, during excitotoxic damage. Ibudilast upregulates multiple signaling pathways, including mTOR, in damaged Müller glia and bipolar cells.
Sumaya Hamadmad, Tyler Heisler‐Taylor, Sandeep Goswami, Evan Hawthorn, Sameer Chaurasia, Dena Martini, Diana Summitt, Ali Zatari, Rahaf Shalash, Misha Sohail, Elizabeth G. Urbanski, Kayla Bernstein, Julie Racine, Abhay Satoskar, Heithem M. El‐Hodiri, Andy J. Fischer, Colleen M. Cebulla   +16 more
wiley   +1 more source

Distinguishing Neuromyelitis Optica Spectrum Disorders Subtypes: A Study on AQP4 and C3d Epitope Expression in Cytokine‐Primed Human Astrocytes

Glia, Volume 73, Issue 5, Page 1090-1106, May 2025.
Main Points An astrocyte assay enhanced by IL‐6, IL‐17A, and IL‐10 distinguished NMOSD subtypes via AQP4 and C3d epitope expression. Clustering analyses revealed autoantibody‐specific patterns, highlighting diagnostic and therapeutic potential. ABSTRACT Neuromyelitis optica spectrum disorders (NMOSD) are severe autoimmune conditions affecting the ...
Marlen Alisch, Franziska Foersterling, Dario Zocholl, Bakhrom Muinjonov, Patrick Schindler, Ankelien Duchnow, Carolin Otto, Klemens Ruprecht, Tanja Schmitz‐Hübsch, Sven Jarius, Friedemann Paul, Volker Siffrin   +11 more
wiley   +1 more source