Results 211 to 220 of about 118,682 (313)

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

Neuroprotection, EarlyView.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu, Chen Wang, Jinyu Zhu, Jiahui Du, Hao Li, Shuyi Ning, Rui Yang, Yiwen Ma, Mengyuan Yuan, Wei Shen, Huailin Wang, Huihui Jiang, Liping Chen, Haitao Wu   +13 more
wiley   +1 more source

Intercellular Mitochondrial Transfer as Endogenous Neuroprotection: Mechanisms and Therapeutic Implications in Ischemic Stroke. [PDF]

Transl Stroke Res
Zhang YF, Zhao D, Wei JJ, Liang X, Wang LD, Wang JW, Jiang LB, Chen JY, Zhang YL, Liu Y.   +9 more
europepmc   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

GLP-1 Receptor Agonists in Acute Ischemic Stroke and Secondary Stroke Prevention: A Narrative Review of Preclinical and Clinical Evidence. [PDF]

J Cent Nerv Syst Dis
Samanidou V, Tsamis K, Ceasovschih A, Koufakis T, Patoulias D, Rizos EC, Rizzo M, Milionis H, Barkas F.   +8 more
europepmc   +1 more source

An open‐source pipeline for longitudinal single‐cell tracking and cell‐cycle/migration coupling analysis for neurotherapeutic screening

Neuroprotection, EarlyView.
Integrated experimental and computational pipeline for longitudinal single‐cell tracking and cell‐cycle dynamics analysis. Schematic of the FUCCI (Fluorescence Ubiquitination‐based Cell Cycle Indicator) reporter system. The construct is driven by the CAG promoter (CMV enhancer + chicken β‐actin promoter) and encodes two fusion proteins: mKO2‐Cdt1 ...
Neha Chandra, Matthew Yang, Hailey Wang, Miroslaw Janowski, Piotr Walczak, Cedric Allier, Yajie Liang   +6 more
wiley   +1 more source

Propofol Attenuates Brain Ischemic Injury Through the Cannabinoid Type 1 (CB1) Receptor. [PDF]

Cureus
Jia J, Cao M, Zhang Y, Lang J, Xiao R, Peng J, Xu B.   +6 more
europepmc   +1 more source

Vascular regeneration and blood flow recovery in glaucoma. [PDF]

Front Cell Dev Biol
Waxman S, Di Polo A.
europepmc   +1 more source

Post‐Omicron cognitive decline is largely reversible: Two‐year multicenter cohort study of domain‐specific outcomes in hospitalized patients

Neuroprotection, EarlyView.
Earlier variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2), including the original strain, Alpha and Delta, were linked to significant and persistent cognitive impairment. The long‐term cognitive impact of Omicron infection, however, has remained uncertain. This study shows that post‐Omicron cognitive decline is largely reversible,
Min Qiu, Mengwen Wang, Shengcai Chen, Wenbo Zuo, Jiashuo Lin, Luojinyun Wang, Senwei Tan, Quanwei He, Yanan Li, Huijuan Jin, Xuan Niu, Wanli Li, Fengguang Li, Ming Huang, Yan Wan, Bo Hu   +15 more
wiley   +1 more source

Neurodegeneration in acute and chronic central nervous system disorders: Novel ideas and approaches

Neuroprotection
Piotr Walczak, Xunming Ji, Shen Li, Johannes Boltze   +3 more
doaj   +1 more source

Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke. [PDF]

CNS Neurosci Ther
Wang Q, Li W, Wu D, Xu S, Ji X.
europepmc   +1 more source