Results 161 to 170 of about 129,703 (302)

Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents. [PDF]

J Enzyme Inhib Med Chem, 2023
Maestro I, Madruga E, Boya P, Martínez A.   +3 more
europepmc   +1 more source

Novel Bioactive Multifunctional Polyphenols: A Chemo‐Enzymatic Approach

Chemistry – A European Journal, EarlyView.
One‐step synthesis of complex alkyl oxystilbenin glucosides (6‐47% yield) in alcoholic medium. Switching to ter‐BuOH as solvent afforded δ‐Viniferin diglucoside, with high selectivity and high yield (> 90%), that can be upgraded by enzymatic esterification to alkyl δ‐Viniferin diglucosides.
Amandine L. Flourat, Emilie Thiébault, Agathe Martinez, Fanny Brunissen, Abdouramane Dosso, Floriane Oszust, Sébastien Blaise, Béatrice Romier, Florent Allais   +8 more
wiley   +1 more source

Natural compounds as inhibitors of transthyretin amyloidosis and neuroprotective agents: analysis of structural data for future drug design [PDF]

, 2020
Lidia Ciccone, Nicolò Tonali, Susanna Nencetti, Elisabetta Orlandini   +3 more
openalex   +1 more source

The Influence of Omega‐3 Fatty Acids and Probiotics on Hippocampal Inflammation and Glial Cells in a Chronic Anorexia Nervosa Rat Model

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with brain volume reduction, glial cell loss, microbiome alterations, and dysregulated pro‐inflammatory mechanisms. However, the underlying cellular mechanisms remain inadequately elucidated, and interventions addressing these alterations are lacking.
A. C. Thelen, N. Andreani, N. M. Korten, M. Neumann, V. Verspohl, M. van Egmond, L. Kneisel, C. Voelz, L. Blischke, J. F. Baines, J. Baier, J. Schumacher, F. Kiessling, B. Herpertz‐Dahlmann, C. Beyer, L. Keller, J. Seitz, S. Trinh   +17 more
wiley   +1 more source

Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B. [PDF]

J Org Chem, 2023
Ghosh AK, Harper M, Robinson WL.
europepmc   +1 more source

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

Exploring Neuroprotective Agents for Sepsis-Associated Encephalopathy: A Comprehensive Review. [PDF]

Int J Mol Sci, 2023
Krzyzaniak K, Krion R, Szymczyk A, Stepniewska E, Sieminski M.   +4 more
europepmc   +1 more source

Simplified immunosuppressive and neuroprotective agents based on gracilin A [PDF]

, 2019
Mikail E. Abbasov, Rebeca Alvariño, Christian M. Chaheine, Eva Alonso, Jon Andoni Sánchez, Michael L. Conner, Amparo Alfonso, Marcel Jaspars, Luís M. Botana, Daniel Romo   +9 more
openalex   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Nanocarriers for the Delivery of Neuroprotective Agents in the Treatment of Ocular Neurodegenerative Diseases. [PDF]

Pharmaceutics, 2023
Patel C, Pande S, Sagathia V, Ranch K, Beladiya J, Boddu SHS, Jacob S, Al-Tabakha MM, Hassan N, Shahwan M.   +9 more
europepmc   +1 more source