Results 161 to 170 of about 114,586 (238)

A Physiologically Based Modeling Approach to Evaluate Intravenous Levetiracetam Dosing in Term and Preterm Neonates

The Journal of Clinical Pharmacology, EarlyView.
Abstract Seizures are the most common neurologic emergency in neonates and are associated with significant morbidity and mortality. Current first‐line pharmacotherapy, phenobarbital, is associated with serious adverse effects, including impairment of the developing brain.
Alexis Johnson, Nolan Thomas, Max Blumenthal, Chrysanthy Ikonomidou, Sin Yin Lim   +4 more
wiley   +1 more source

Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein. [PDF]

Bioimpacts, 2022
Rajeshkumar RR, Kumar BK, Parasuraman P, Panneerselvam T, Sundar K, Ammunje DN, Ram Kumar Pandian S, Murugesan S, Kabilan SJ, Kunjiappan S.   +9 more
europepmc   +1 more source

Liposomal Ficus carica latex and ficin effects on human colon cancer cell line

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Challenges such as metabolic instability, short half‐life, poor absorption, and low bioavailability are faced by natural drug candidates, particularly in complex plant‐derived extracts like fig latex, which contains multiple bioactive compounds that complicate standardization and encapsulation.
Olcay Boyacioğlu, Seçil Tecimen, Seda Örenay Boyacioğlu   +2 more
wiley   +1 more source

Preemptive Propofol Administration in Spinal Cord Injury: Effects on Pain‐Induced Hypertension, Neuroinflammation, and Functional Recovery in Rats

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Spinal cord injury (SCI) triggers secondary damage, including pain‐induced hypertension, inflammation, and hemorrhage, impairing recovery. This study evaluated the efficacy of general anesthesia with preemptive propofol administration in mitigating secondary damage in SCI rats. SCI was induced in rats using a contusion model.
Qun Cheng, Xiang‐Yu Fang, Rong‐En Qiu   +2 more
wiley   +1 more source

Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2. [PDF]

Redox Rep
Yao H, Wu R, Du D, Ai F, Yang F, Li Y, Qi S.   +6 more
europepmc   +1 more source

Natural Products as Novel Neuroprotective Agents; Computational Predictions of the Molecular Targets, ADME Properties, and Safety Profile. [PDF]

Plants (Basel), 2022
Alghamdi SS, Suliman RS, Aljammaz NA, Kahtani KM, Aljatli DA, Albadrani GM.   +5 more
europepmc   +1 more source

Relaxin‐2 Ameliorates Spinal Cord Injury by Inhibiting Microglia Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aims to assess the therapeutic effectiveness of Relaxin‐2 (RLN‐2) in promoting functional recovery and neuroprotection following spinal cord injury (SCI) in mice. Furthermore, continuous subcutaneous infusion of Serelaxin (0.5 mg/kg/day; human recombinant relaxin‐2) improved neurological recovery, as evidenced by higher Basso ...
Ji‐Huan Wang, Hong‐Biao Sheng, Jun‐Kun Li   +2 more
wiley   +1 more source

Essential Oil Constituents as Anti-Inflammatory and Neuroprotective Agents: An Insight through Microglia Modulation. [PDF]

Int J Mol Sci
Stojanović NM, Ranđelović PJ, Simonović M, Radić M, Todorović S, Corrigan M, Harkin A, Boylan F.   +7 more
europepmc   +1 more source

Novel anti-apoptotic L-DOPA precursors SuperDopa and SuperDopamide as potential neuroprotective agents for halting/delaying progression of Parkinson's disease. [PDF]

Cell Death Dis, 2022
Wiesen T, Atlas D.
europepmc   +1 more source

Magnetic Levitational Assembly of Differentiated SH‐SY5Y Cells for Aβ‐Induced 3D Alzheimer's Disease Modeling and Curcumin Screening

Macromolecular Bioscience, EarlyView.
This study explores the 3D modeling of Alzheimer's disease using differentiated SH‐SY5Y spheroids via Magnetic levitation (MagLev) and investigates the neuroprotective effect of Curcumin. Differentiated spheroids displayed high viability and significant neuronal characteristics. Aβ 1‐42 exhibited neurotoxic effects on differentiated spheroids. Curcumin
Rumeysa Bilginer‐Kartal, Ahu Arslan‐Yildiz   +1 more
wiley   +1 more source