Results 141 to 150 of about 87,298 (292)

Neuroprotective actions of novel and potent ligands of group I and group II metabotropic glutamate receptors

, 1999
The role of group I metabotropic glutamate (mGlu) receptors in neurodegeneration is controversial because of the contradictory effects of mGlu1/5 agonists in in vitro models of neuronal cell death.
A. Bond, B. Trembly, NICOLETTI, Ferdinando, D. Lodge, W. Slikker, A. E. Kingston, D. D. Schoepp, BATTAGLIA, Giuseppe, G. BATTAGLIA, B. P. Clark, BRUNO, Valeria Maria Gloria, M. J. O'Neill, F. NICOLETTI, J. R. Harris, V. BRUNO, J. A. Monn   +15 more
core   +1 more source

Green Fuel Combustion Synthesis of CeO2 and Ag/CeO2 Nanoparticles for Photocatalytic and Antibacterial Applications

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Silver‐doped cerium oxide nanoparticles (Ag/CeO2 NPs) were synthesized using Ricinus communis seed extract as a bio‐derived fuel in a solution combustion method. The combustion reaction, carried out at 450°C with AgNO3 and (NH4)2[Ce (NO3)6] as metal precursors, produced CeO2 and Ag/CeO2 NPs.
T. N. Ravishankar, J. R. Adarsha, R. Mohan Reddy, S. Harisha, A. Ananda, B. M. Shilpa   +5 more
wiley   +1 more source

Novel norbornane derivatives as potential neuroprotective agents [PDF]

, 2020
Philosophiae Doctor - PhDNeurodegenerative disorders are characterised by progressive loss of the brain’s physiological functions as a result of gradual degeneration of neurons in the central nervous system.
Egunlusi, Ayodeji Olatunde
core  

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

[Neuroprotective agents].

Neurologia (Barcelona, Spain), 2000
In the last decade, a huge number of drugs have been developed in order to block the different molecular reactions of the ischemic cascade. Most of neuroprotective compounds decrease infarct volume in experimental stroke models, but none of them has reduced stroke mortality and morbidity in clinical trials.
openaire   +1 more source

Atomically precise metal cluster enzymes for pathological tissue regeneration

BMEMat, EarlyView.
Schematic illustration of atomically precise metal cluster enzymes (MCEs) for pathological tissue regeneration. Atomically precise MCEs can modulate biological processes, such as attenuation of inflammatory responses, eradication of bacterial pathogens, regulation of angiogenesis, and promotion of cell development.
Ziqiang Xiong, Zhifeng Shi, Mengqing Li, Jien Han, Haoyan Chen, Maofei Ran, Shaojian Zhong, Limin Ma, Chengyun Ning, Youzhun Fan, Zhenghua Tang, Peng Yu   +11 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Global Trends and Advances in Traumatic Brain Injury

Brain Health, EarlyView.
ABSTRACT Traumatic brain injury (TBI) remains a major global public health challenge, contributing substantially to morbidity and mortality while imposing a significant socioeconomic burden. In recent years, notable progress has been made in understanding TBI pathophysiology, classification, monitoring, and treatment.
Yuan Zhuang, Xixian Liao, Jiyao Jiang, Guoyi Gao   +3 more
wiley   +1 more source

Discovery of novel N-(prop-2-yn-1-yl)-1,2,3,4-tetrahydronaphthalen-1-amine derivatives as MAO-B inhibitors for the treatment of Parkinson’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry
Monoamine oxidase B (MAO-B) inhibitors may be an effective therapeutic approach for Parkinson’s disease. This study designed and synthesised a series of N-(prop-2-yn-1-yl)-1,2,3,4-tetrahydronaphthalen-1-amine derivatives and evaluated their inhibitory ...
Ziwei Wang, Jing Feng, Chengwan Yi, Wanping Zhang, Xianwu Fu, Yu Yu   +5 more
doaj   +1 more source

Size-controllable striatal lesion model for evaluation of neuroprotective agents in rats

, 2013
ObjectivesVarious focal brain lesions are primarily caused by excessive glutamate release. An easy and convenient in vivo striatal lesion model was developed in which reliable and controllable lesion sizes were created by glutamate for evaluation of ...
Pang, Cheng-Yoong, Kuo, Jon-Son, Chuang, Jia-Ying, Liew, Hock-Kean   +3 more
core   +1 more source