Results 121 to 130 of about 87,298 (292)

Efficient Two-Step Synthesis of Novel Pyrimido[4,5-d] Pyrimidines with Potent Neuroprotective, Antioxidant, and Aβ Anti-Aggregation Properties

Chemistry
Eleven new differently substituted N,7-diphenylpyrimido [4,5-d]pyrimidin-4-amines 4a–k were synthesized from readily available reagents in a simple and inexpensive two-step procedure with yields up to 57%.
Ghada Ben Ameur, Emna Maalej, Helene Martin, Anne-Sophie Jacquinot, Nadine Barbanneau, Paul J. Bernard, José Marco-Contelles, Fakher Chabchoub, Lhassane Ismaili   +8 more
doaj   +1 more source

Neuroprotective potential of Mucuna pruriens in cerebral ischemia: Evidence from animal models and implications for translational neuropharmacology [PDF]

Veterinary World
Background and Aim: Cerebral ischemia is a major neurological condition that contributes significantly to global morbidity and mortality. It occurs due to reduced blood supply to the brain, leading to neuronal injury and death.
Vanishri Sunil Nayak, Karkala Sreedhara Ranganath Pai, Bukkambudhi Virupakshamurthy Murlimanju, Sunil Sanjiva Nayak, Suhani Sumalatha, Mamatha Tonse   +5 more
doaj   +1 more source

Synthesis of Fluoroflavones as Potential Neuroprotective Agents

, 2019
Flavones are polyphenol natural products that are known to have neuroprotective effects against many diseases caused by the formation of reactive species. Flavonoids are subgroup of flavones and they are believed to function as antioxidants. Specifically,
Alshammari, Maali
core  

A Select Combination of Neurotrophins Enhances Neuroprotection and Functional Recovery following Spinal Cord Injury

, 2007
Previously, we have shown that topical application of brain-derived neurotrophic factor (BDNF) or insulin-like growth factor 1 (IGF-1) given within 5 to 30 min after a focal trauma to the rat spinal cord attenuates spinal cord injury (SCI)-induced ...
HARI SHANKER SHARMA, Sharma, Hari Shanker,   +1 more
core   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Biomimetic Hydrogel System Targeting S100A8 Centered Neuroimmune Crosstalk and Hypoxia Induced Neuronal Injury

Advanced Science, EarlyView.
A biomimetic hydrogel (HPC@Gel) was developed for traumatic brain injury repair by combining oxygen‐carrying hemoglobin nanoparticles and anti‐inflammatory carbon quantum dots within a brain‐like matrix. The system alleviated hypoxia, reduced harmful neuroimmune signaling, protected neurons, supported neural regeneration, and improved neurological and ...
Peng Liu, Xiaoyang Wu, Xiaoyin Liu, Yuyan Wang, Shichao Jiang, Kai Wu, Gaowei Li, Jie Ding, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan, Liangxue Zhou   +12 more
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Hypoxia-inducible factor-1: A new neuroprotective agent for the treatment of hyperglycemia after stroke

Neural Regeneration Research
Acute hyperglycemia in ischemic stroke occurs in almost half of cases, inducing a worsening of the underlying pathophysiology. Hence, the management of acute hyperglycemia during the first hours following ischemic stroke requires well-defined strategies.
María Isabel Hernández, José L. Zugaza, Abraham Martín   +2 more
doaj   +1 more source

Polycyclic propargylamine and acetylene derivatives as multifunctional neuroprotective agents

, 2014
Supplementary data related to this article can be found at http://dx.doi.org/10.1016/j.ejmech.2014.04.039The aim of this study was to design drug-like molecules with multiple neuroprotective mechanisms which would ultimately inhibit N-methyl-D-aspartate
Barber, Quinton R., Petzer, Jacobus P., Zindo, Frank T., Bergh, Jacobus J., Malan, Sarel F.   +4 more
core   +1 more source

Neuroprotective agents as an adjuvant treatment in patients with acute spinal cord injuries : a qualitative systematic review of randomized trials.

, 2020
This was a systematic literature review.The objective of this study was to evaluate randomized clinical trials that address potential neuroprotective agents used to improve neurological outcome in patients with spinal cord injury (SCI).Clinical treatment
AF, Joaquim,, AR, Vaccaro, AR, GD, Schroeder,, JW, Daniel,   +3 more
core   +1 more source